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Theses & Dissertations: Cancer Research

Theses/dissertations from 2024 2024.

Novel Spirocyclic Dimer (SpiD3) Displays Potent Preclinical Effects in Hematological Malignancies , Alexandria Eiken

Chemotherapy-Induced Modulation of Tumor Antigen Presentation , Alaina C. Larson

Understanding the role of MASTL in colon homeostasis and colitis-associated cancer development , Kristina Pravoverov

Dying Right: Supporting Anti-Cancer Therapy Through Immunogenic Cell Death , Elizabeth Schmitz

Therapeutic Effects of BET Protein Inhibition in B-cell Malignancies and Beyond , Audrey L. Smith

Targeting KSR1 to inhibit stemness and therapy resistance , Heidi M. Vieira

Identifying the Molecular Determinants of Lung Metastatic Adaptation in Prostate Cancer , Grace M. Waldron

Identification of Mitotic Phosphatases and Cyclin K as Novel Molecular Targets in Pancreatic Cancer , Yi Xiao

Theses/Dissertations from 2023 2023

Development of Combination Therapy Strategies to Treat Cancer Using Dihydroorotate Dehydrogenase Inhibitors , Nicholas Mullen

Overcoming Resistance Mechanisms to CDK4/6 Inhibitor Treatment Using CDK6-Selective PROTAC , Sarah Truong

Theses/Dissertations from 2022 2022

Omics Analysis in Cancer and Development , Emalie J. Clement

Investigating the Role of Splenic Macrophages in Pancreatic Cancer , Daisy V. Gonzalez

Polymeric Chloroquine in Metastatic Pancreatic Cancer Therapy , Rubayat Islam Khan

Evaluating Targets and Therapeutics for the Treatment of Pancreatic Cancer , Shelby M. Knoche

Characterization of 1,1-Diarylethylene FOXM1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells , Cassie Liu

Novel Mechanisms of Protein Kinase C α Regulation and Function , Xinyue Li

SOX2 Dosage Governs Tumor Cell Identity and Proliferation , Ethan P. Metz

Post-Transcriptional Control of the Epithelial-to-Mesenchymal Transition (EMT) in Ras-Driven Colorectal Cancers , Chaitra Rao

Use of Machine Learning Algorithms and Highly Multiplexed Immunohistochemistry to Perform In-Depth Characterization of Primary Pancreatic Tumors and Metastatic Sites , Krysten Vance

Characterization of Metastatic Cutaneous Squamous Cell Carcinoma in the Immunosuppressed Patient , Megan E. Wackel

Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling , Pauline Xu

Phos-Tag-Based Screens Identify Novel Therapeutic Targets in Ovarian Cancer and Pancreatic Cancer , Renya Zeng

Theses/Dissertations from 2021 2021

Functional Characterization of Cancer-Associated DNA Polymerase ε Variants , Stephanie R. Barbari

Pancreatic Cancer: Novel Therapy, Research Tools, and Educational Outreach , Ayrianne J. Crawford

Apixaban to Prevent Thrombosis in Adult Patients Treated With Asparaginase , Krishna Gundabolu

Molecular Investigation into the Biologic and Prognostic Elements of Peripheral T-cell Lymphoma with Regulators of Tumor Microenvironment Signaling Explored in Model Systems , Tyler Herek

Utilizing Proteolysis-Targeting Chimeras to Target the Transcriptional Cyclin-Dependent Kinases 9 and 12 , Hannah King

Insights into Cutaneous Squamous Cell Carcinoma Pathogenesis and Metastasis Using a Bedside-to-Bench Approach , Marissa Lobl

Development of a MUC16-Targeted Near-Infrared Antibody Probe for Fluorescence-Guided Surgery of Pancreatic Cancer , Madeline T. Olson

FGFR4 glycosylation and processing in cholangiocarcinoma promote cancer signaling , Andrew J. Phillips

Theses/Dissertations from 2020 2020

Cooperativity of CCNE1 and FOXM1 in High-Grade Serous Ovarian Cancer , Lucy Elge

Characterizing the critical role of metabolic and redox homeostasis in colorectal cancer , Danielle Frodyma

Genomic and Transcriptomic Alterations in Metabolic Regulators and Implications for Anti-tumoral Immune Response , Ryan J. King

Dimers of Isatin Derived Spirocyclic NF-κB Inhibitor Exhibit Potent Anticancer Activity by Inducing UPR Mediated Apoptosis , Smit Kour

From Development to Therapy: A Panoramic Approach to Further Our Understanding of Cancer , Brittany Poelaert

The Cellular Origin and Molecular Drivers of Claudin-Low Mammary Cancer , Patrick D. Raedler

Mitochondrial Metabolism as a Therapeutic Target for Pancreatic Cancer , Simon Shin

Development of Fluorescent Hyaluronic Acid Nanoparticles for Intraoperative Tumor Detection , Nicholas E. Wojtynek

Theses/Dissertations from 2019 2019

The role of E3 ubiquitin ligase FBXO9 in normal and malignant hematopoiesis , R. Willow Hynes-Smith

BRCA1 & CTDP1 BRCT Domainomics in the DNA Damage Response , Kimiko L. Krieger

Targeted Inhibition of Histone Deacetyltransferases for Pancreatic Cancer Therapy , Richard Laschanzky

Human Leukocyte Antigen (HLA) Class I Molecule Components and Amyloid Precursor-Like Protein 2 (APLP2): Roles in Pancreatic Cancer Cell Migration , Bailee Sliker

Theses/Dissertations from 2018 2018

FOXM1 Expression and Contribution to Genomic Instability and Chemoresistance in High-Grade Serous Ovarian Cancer , Carter J. Barger

Overcoming TCF4-Driven BCR Signaling in Diffuse Large B-Cell Lymphoma , Keenan Hartert

Functional Role of Protein Kinase C Alpha in Endometrial Carcinogenesis , Alice Hsu

Functional Signature Ontology-Based Identification and Validation of Novel Therapeutic Targets and Natural Products for the Treatment of Cancer , Beth Neilsen

Elucidating the Roles of Lunatic Fringe in Pancreatic Ductal Adenocarcinoma , Prathamesh Patil

Theses/Dissertations from 2017 2017

Metabolic Reprogramming of Pancreatic Ductal Adenocarcinoma Cells in Response to Chronic Low pH Stress , Jaime Abrego

Understanding the Relationship between TGF-Beta and IGF-1R Signaling in Colorectal Cancer , Katie L. Bailey

The Role of EHD2 in Triple-Negative Breast Cancer Tumorigenesis and Progression , Timothy A. Bielecki

Perturbing anti-apoptotic proteins to develop novel cancer therapies , Jacob Contreras

Role of Ezrin in Colorectal Cancer Cell Survival Regulation , Premila Leiphrakpam

Evaluation of Aminopyrazole Analogs as Cyclin-Dependent Kinase Inhibitors for Colorectal Cancer Therapy , Caroline Robb

Identifying the Role of Janus Kinase 1 in Mammary Gland Development and Breast Cancer , Barbara Swenson

DNMT3A Haploinsufficiency Provokes Hematologic Malignancy of B-Lymphoid, T-Lymphoid, and Myeloid Lineage in Mice , Garland Michael Upchurch

Theses/Dissertations from 2016 2016

EHD1 As a Positive Regulator of Macrophage Colony-Stimulating Factor-1 Receptor , Luke R. Cypher

Inflammation- and Cancer-Associated Neurolymphatic Remodeling and Cachexia in Pancreatic Ductal Adenocarcinoma , Darci M. Fink

Role of CBL-family Ubiquitin Ligases as Critical Negative Regulators of T Cell Activation and Functions , Benjamin Goetz

Exploration into the Functional Impact of MUC1 on the Formation and Regulation of Transcriptional Complexes Containing AP-1 and p53 , Ryan L. Hanson

DNA Polymerase Zeta-Dependent Mutagenesis: Molecular Specificity, Extent of Error-Prone Synthesis, and the Role of dNTP Pools , Olga V. Kochenova

Defining the Role of Phosphorylation and Dephosphorylation in the Regulation of Gap Junction Proteins , Hanjun Li

Molecular Mechanisms Regulating MYC and PGC1β Expression in Colon Cancer , Jamie L. McCall

Pancreatic Cancer Invasion of the Lymphatic Vasculature and Contributions of the Tumor Microenvironment: Roles for E-selectin and CXCR4 , Maria M. Steele

Altered Levels of SOX2, and Its Associated Protein Musashi2, Disrupt Critical Cell Functions in Cancer and Embryonic Stem Cells , Erin L. Wuebben

Theses/Dissertations from 2015 2015

Characterization and target identification of non-toxic IKKβ inhibitors for anticancer therapy , Elizabeth Blowers

Effectors of Ras and KSR1 dependent colon tumorigenesis , Binita Das

Characterization of cancer-associated DNA polymerase delta variants , Tony M. Mertz

A Role for EHD Family Endocytic Regulators in Endothelial Biology , Alexandra E. J. Moffitt

Biochemical pathways regulating mammary epithelial cell homeostasis and differentiation , Chandrani Mukhopadhyay

EPACs: epigenetic regulators that affect cell survival in cancer. , Catherine Murari

Role of the C-terminus of the Catalytic Subunit of Translesion Synthesis Polymerase ζ (Zeta) in UV-induced Mutagensis , Hollie M. Siebler

LGR5 Activates TGFbeta Signaling and Suppresses Metastasis in Colon Cancer , Xiaolin Zhou

LGR5 Activates TGFβ Signaling and Suppresses Metastasis in Colon Cancer , Xiaolin Zhou

Theses/Dissertations from 2014 2014

Genetic dissection of the role of CBL-family ubiquitin ligases and their associated adapters in epidermal growth factor receptor endocytosis , Gulzar Ahmad

Strategies for the identification of chemical probes to study signaling pathways , Jamie Leigh Arnst

Defining the mechanism of signaling through the C-terminus of MUC1 , Roger B. Brown

Targeting telomerase in human pancreatic cancer cells , Katrina Burchett

The identification of KSR1-like molecules in ras-addicted colorectal cancer cells , Drew Gehring

Mechanisms of regulation of AID APOBEC deaminases activity and protection of the genome from promiscuous deamination , Artem Georgievich Lada

Characterization of the DNA-biding properties of human telomeric proteins , Amanda Lakamp-Hawley

Studies on MUC1, p120-catenin, Kaiso: coordinate role of mucins, cell adhesion molecules and cell cycle players in pancreatic cancer , Xiang Liu

Epac interaction with the TGFbeta PKA pathway to regulate cell survival in colon cancer , Meghan Lynn Mendick

Theses/Dissertations from 2013 2013

Deconvolution of the phosphorylation patterns of replication protein A by the DNA damage response to breaks , Kerry D. Brader

Modeling malignant breast cancer occurrence and survival in black and white women , Michael Gleason

The role of dna methyltransferases in myc-induced lymphomagenesis , Ryan A. Hlady

Design and development of inhibitors of CBL (TKB)-protein interactions , Eric A. Kumar

Pancreatic cancer-associated miRNAs : expression, regulation and function , Ashley M. Mohr

Mechanistic studies of mitochondrial outer membrane permeabilization (MOMP) , Xiaming Pang

Novel roles for JAK2/STAT5 signaling in mammary gland development, cancer, and immune dysregulation , Jeffrey Wayne Schmidt

Optimization of therapeutics against lethal pancreatic cancer , Joshua J. Souchek

Theses/Dissertations from 2012 2012

Immune-based novel diagnostic mechanisms for pancreatic cancer , Michael J. Baine

Sox2 associated proteins are essential for cell fate , Jesse Lee Cox

KSR2 regulates cellular proliferation, transformation, and metabolism , Mario R. Fernandez

Discovery of a novel signaling cross-talk between TPX2 and the aurora kinases during mitosis , Jyoti Iyer

Regulation of metabolism by KSR proteins , Paula Jean Klutho

The role of ERK 1/2 signaling in the dna damage-induced G2 , Ryan Kolb

Regulation of the Bcl-2 family network during apoptosis induced by different stimuli , Hernando Lopez

Studies on the role of cullin3 in mitosis , Saili Moghe

Characteristics of amyloid precursor-like protein 2 (APLP2) in pancreatic cancer and Ewing's sarcoma , Haley Louise Capek Peters

Structural and biophysical analysis of a human inosine triphosphate pyrophosphatase polymorphism , Peter David Simone

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Student theses

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A biologically-inspired artificial lateral line: observations of collective behaviour in fish lead to the development of a novel design of simple and low-cost artificial lateral line sensor.

Supervisor: Hauert, S. (Supervisor), Ioannou, C. (Supervisor) & Genner, M. J. (Supervisor)

Student thesis : Doctoral Thesis › Doctor of Philosophy (PhD)

A characterisation of mononuclear phagocyte dynamics in the healthy and regenerating zebrafish heart

Supervisor: Richardson, B. (Supervisor) & Martin, P. B. (Supervisor)

A Computational Framework for the Optimisation of Antivenom Pharmacokinetics and Pharmacodynamics

Supervisor: Hauert, S. (Supervisor), Blee, J. A. (Supervisor) & Collinson, I. R. (Supervisor)

An Epigenome-Wide Association Study of Eczema

Supervisor: Paternoster, L. (Supervisor), Elliott, H. (Supervisor) & Relton, C. (Supervisor)

Student thesis : Master's Thesis › Master of Science by Research (MScR)

An Investigation into the Link Between Sleep and Alzheimer’s Disease Using a Multi-Method Approach

Supervisor: Coulthard, E. J. (Supervisor) & Ben-Shlomo, Y. (Supervisor)

Applications of HS-AFM Imaging to Marine Microbial Life and its Environment

Supervisor: Day, J. C. C. (Supervisor), Picco, L. M. (Supervisor), Payton, O. D. (Supervisor) & Allen, M. (Supervisor)

Applying ‘omics to understand and predict juvenile idiopathic arthritis

Supervisor: Relton, C. (Supervisor), Ramanan, A. (Supervisor), Sharp, G. (Supervisor) & Zhou, Y. (External person) (Supervisor)

Appraising the causal relationship between DNA methylation and type 2 diabetes

Supervisor: Elliott, H. (Supervisor), Relton, C. (Supervisor) & Sharp, G. (Supervisor)

A qualitative exploration of recruiters' and patients' perspectives and experiences of the recruitment encounter in randomised controlled trials

Supervisor: Young, B. (Supervisor), Rooshenas, L. (Supervisor), Elliott, D. (Supervisor), Jepson, M. (Supervisor) & Donovan , J. L. (Supervisor)

Arole for IGFBP-2 in DNA repair in breast cancer cells

Supervisor: Perks, C. (Supervisor), Holly, J. (Supervisor) & Biernacka, K. M. (Supervisor)

Assessing the feasibility of dietary restriction, including short-term fasting, at the time of chemotherapy

Supervisor: Atkinson, C. (Supervisor), Herbert, G. (Supervisor), Ness, A. (Supervisor) & Perks, C. (Supervisor)

A study of hyperspectral reflectance and fluorescence imaging as alternative Methods for assessing coral health

Supervisor: Day, J. (Supervisor) & Scott, T. (Supervisor)

Biological and lifestyle predictors of survival in head and neck cancer.

Supervisor: Dos Santos Ferreira, D. (Supervisor), Ingle, S. (Supervisor), Ness, A. (Supervisor), Martin, R. (Supervisor) & May, M. T. (Supervisor)

Biosynthetic Studies on Kalimantacin Antibiotics

Supervisor: Willis, C. L. (Supervisor) & Crump, M. P. (Supervisor)

Capturing complexity, comorbidity and frailty in people with parkinsonism and understanding their impact

Supervisor: Ben-Shlomo, Y. (Supervisor) & Henderson, E. (Supervisor)

Causal implications of common infections and platelet function on cardiovascular disease

Supervisor: Paternoster, L. (Supervisor), Richmond, R. (Supervisor), Davey Smith, G. (Supervisor) & Poole, A. (Supervisor)

Causal pathways from cognitive ability to Alzheimer's disease

Supervisor: Davies, N. M. (Supervisor), Anderson, E. L. (Supervisor), Howe, L. D. (Supervisor) & Ben-Shlomo, Y. (Supervisor)

Characterisation of Ataxia Telangiectasia Mutated in RPE-1 cells and its role in cellular sensitivity to hypo-osmotic stress

Supervisor: Mellor, H. H. (Supervisor) & Wood, W. J. (Supervisor)

Characterisation of the cellular compartments containing inhibitory receptors in CD8 + T cells

Supervisor: Wuelfing, C. (Supervisor) & Morgan, D. (Supervisor)

Characterisation of the HELLS and Irc5 subfamily of chromatin remodellers

Supervisor: Dillingham, M. (Supervisor) & Chambers, A. (Supervisor)

Characterising Red Cell-Derived Vesicles in Sickle Cell Disease and Investigating Potential to Induce Tolerance to Human Red Cell Antigens

Supervisor: Blair, A. (Supervisor) & Anstee, D. J. (Supervisor)

Complex trait architecture through the lens of epigenome-wide association studies

Supervisor: Gaunt, T. (Supervisor), Hemani, G. (Supervisor) & Timpson, N. J. (Supervisor)

Decentralised Algorithms for Area Coverage

Supervisor: Ganesh, A. (Supervisor) & Hauert, S. (Supervisor)

Dental care pathways and parent-reported dental outcomes for 5-year-old children born with a cleft in the UK

Supervisor: Fowler, P. V. (Supervisor), Leary, S. D. (Supervisor), Wren, Y. E. (Supervisor) & Williams, J. (Supervisor)

Student thesis : Doctoral Thesis › Doctor of Dental Surgery (DDS)

Diabetes mellitus causes adiposopathy in bone marrow: investigation of the underpinning cellular and molecular mechanisms

Supervisor: Madeddu, P. (Supervisor) & Mellor, H. H. (Supervisor)

Dissecting causal relationships and molecular mechanisms in disease using genetic risk profiles

Supervisor: Richardson, T. G. (Supervisor), Gaunt, T. R. (Supervisor) & Davey Smith, G. (Supervisor)

Does the association between later eating rhythm and childhood adiposity differ between the UK and China?

Supervisor: Leary, S. D. (Supervisor) & Northstone, K. (Supervisor)

Does the IGF axis influence EMT to play a role in bladder cancer progression?

Supervisor: Perks, C. (Supervisor) & Holly, J. M. P. (Supervisor)

Elucidating mechanisms of tumour resistance to checkpoint blockade

Supervisor: Wooldridge, L. (Supervisor), Morgan, D. (Supervisor) & Wuelfing, C. (Supervisor)

Enhanced numerical techniques for time domain electromagnetic analysis

Evaluation of a primary care epilepsy specialist nurse service.

Supervisor: Bachmann, M. (Supervisor)

Evaluation of Cardiopulmonary Exercise Testing (CPET) as a Prognostic Tool in Idiopathic Pulmonary Fibrosis (IPF)

Supervisor: Maskell, N. (Supervisor) & Millar, A. (Supervisor)

Evolving Morphological Adaption Methods in Compliant Robots

Supervisor: Hauser, H. (Supervisor) & Hauert, S. (Supervisor)

Examining the Role of Placental-derived MicroRNA Secretions in Response to Gestational Hypoxia on Foetal Neurodevelopment

Supervisor: Case, C. P. (Supervisor), Perks, C. M. (Supervisor), Uney, J. B. (Supervisor) & Fulga, T. A. (External person) (Supervisor)

Expertise during surgical innovation: advancing understanding about non-technical skills and related optimisation factors

Supervisor: Mills, N. (Supervisor), Blencowe, N. (Supervisor) & Blazeby, J. (Supervisor)

Exploring the effect of adiposity on platelet function and related pathways: implications for cardiovascular disease

Supervisor: Timpson, N. (Supervisor) & Hers, I. (Supervisor)

Exploring the in vitro behaviour of endothelial cells in different cell culture models

Supervisor: Mellor, H. (Supervisor) & Gaston, K. (Supervisor)

Exploring the microclot-driven pre-metastatic niche: live imaging studies in zebrafish larvae

Supervisor: Martin, P. B. (Supervisor) & Nobes, C. D. (Supervisor)

Exploring the role of BCL-3 in colorectal cancer cell therapeutic resistance

Supervisor: Martin, P. (Supervisor), Cullen, P. (Supervisor) & Williams, A. (Supervisor)

Extra-pulmonary effects of lung function and lung disease

Supervisor: Davey Smith, G. (Supervisor), Dodd, J. (Supervisor) & Granell, R. (Supervisor)

Fatty acid construction within the biosynthesis of the polyketide antibiotic mupirocin

Supervisor: Crump, M. P. (Supervisor), Willis, C. (External person) (Supervisor) & Race, P. R. (Supervisor)

Feeding and Autoimmunity in Children with Down’s Syndrome Evaluation Study (FADES)

Supervisor: Hamilton-Shield, J. P. (Supervisor), Gillespie, K. M. (Supervisor) & Leary, S. D. (Supervisor)

From peptide oligomers to single-chain proteins

Supervisor: Woolfson, D. (Supervisor) & Crump, M. (Supervisor)

Genetic and Environmental Contributions to Trajectories of Depressive Symptoms

Supervisor: Manley, D. (Supervisor), Timpson, N. J. (Supervisor) & Leckie, G. (Supervisor)

Genetic and epidemiologic approaches to elucidate the role of abnormal hip shape in the development of hip osteoarthritis

Supervisor: Davey Smith, G. (Supervisor) & Tobias, J. (Supervisor)

Genetic and epigenetic data as a tool to augment understanding of oropharyngeal cancer

Supervisor: Relton, C. L. (Supervisor), Thomas, S. J. (Supervisor), Richmond, R. C. (Supervisor) & Elliott, H. R. (Supervisor)

Geographical gene-environment interaction and correlation for mental health in the UK and Sweden

Supervisor: Davis, O. S. (Supervisor) & Davey Smith, G. (Supervisor)

Glial autophagy capability and the control of neuroinflammatory signaling in Parkinson’s disease.

Supervisor: Lane, J. D. (Supervisor) & Carroll, B. M. (Supervisor)

'Hi-Fi Nanoscience' : Exploring the nanoscale with optical pickup units

Supervisor: Payton, O. D. (Supervisor) & Day, J. C. C. (Supervisor)

High-throughput proteomic analysis of the dengue virus secretome and the identification of plasma biomarkers of disease severity

Supervisor: Morgan, D. (Supervisor) & Davidson, A. (Supervisor)

UKnowledge > College of Medicine > Toxicology and Cancer Biology > Theses & Dissertations

Theses and Dissertations--Toxicology and Cancer Biology

Theses/dissertations from 2024 2024.

UNDERSTANDING THE MECHANISM OF FERROPTOSIS SUSCEPTIBILITY VARIATION IN COLORECTAL CANCER , Aziza Alshahrani

Elucidation of Mismatch Repair Regulation by ABL1: Advantages/Disadvantages of Tyrosine Kinase Inhibitor Treatment , Hannah Daniels

RPS6KB1 IS A CRITICAL TARGET FOR OVERCOMING TUMOR LINEAGE PLASTICITY AND THERAPY RESISTANCE , Saptadwipa Ganguly

PORCUPINE’S ROLE IN THE ENHANCEMENT OF ENZALUTAMIDE EFFICACY IN DRUG RESISTANT PROSTATE CANCER , Katelyn Jones

ACQUIRED TREATMENT RESISTANCE IN PROSTATE CANCER VIA THE PRODUCTION OF RADIATION DERIVED EXTRACELLULAR VESICLES CONTAINING MITOCHONDRIAL PROTEINS , Caitlin Miller

Delineating Contributions of Genotype and Lineage to Lung Cancer Therapy Response , Kassandra Jo Naughton

THE CRITICAL ROLE OF NAC1 IN TRIPLE-NEGATIVE BREAST CANCER STEMNESS AND IMMUNOSUPPRESSION , chrispus ngule

THERAPEUTIC APPROACHES AND NOVEL MECHANSIMS IN CANCER PROGRESSION , Kendall Simpson

Theses/Dissertations from 2023 2023

ELUCIDATING THE FUNCTIONAL IMPORTANCE OF PEROXIREDOXIN IV IN PROSTATE CANCER AND ITS SECRETION MECHANISM , Na Ding

Targeting EZH2 to Improve Outcomes of Lung Squamous Cell Carcinoma , Tanner DuCote

UNDERSTANDING AND TARGETING THE TPH1-SEROTONIN-HTR3A AXIS IN SMALL CELL LUNG CANCER , Yanning Hao

CONSERVED NOVEL INTERACTIONS BETWEEN POST-REPLICATIVE REPAIR AND MISMATCH REPAIR PROTEINS HAVE DIFFERENTIAL EFFECTS ON DNA REPAIR PATHWAYS , Anna K. Miller

UNDERSTANDING THE ROLE OF PEROXIREDOXIN IV IN COLORECTAL CANCER DEVELOPMENT , Pratik Thapa

BEYOND MITOSIS, PLK1-MEDIATED PHOSPHORYLATION RE-WIRES CANCER METABOLISM AND PROMOTES CANCER PROGRESSION , Qiongsi Zhang

Theses/Dissertations from 2022 2022

ELUCIDATING THE ROLE OF POLYCOMB REPRESSIVE COMPLEX 2 IN LUNG STEM CELL FATE AND LUNG DISEASE , Aria Byrd

SEX DIMORPHISM IN HEMATOPOIESIS AND BONE MARROW NICHE , xiaojing cui

EXTRACELLULAR VESICLES AND CANCER THERAPY: AN INSIGHT INTO THE ROLE OF OXIDATIVE STRESS , Jenni Ho

OVERCOMING RESISTANCE TO SG-ARIS IN CASTRATION-RESISTANT PROSTATE CANCER , Chaohao Li

Theses/Dissertations from 2021 2021

THE TUMOR SUPPRESSOR PAR-4 REGULATES HYPERTROPHIC OBESITY , Nathalia Araujo

Epigenetic States Regulate Tumor Aggressiveness and Response to Targeted Therapies in Lung Adenocarcinoma , Fan Chen

DELINEATING THE ROLE OF FATTY ACID METABOLISM TO IMPROVE THERAPEUTIC STRATEGIES FOR COLORECTAL CANCER , James Drury

DEVELOPMENT OF TOOLS FOR ATOM-LEVEL INTERPRETATION OF STABLE ISOTOPE-RESOLVED METABOLOMICS DATASETS , Huan Jin

MECHANISMS OF CADMIUM-INDUCED AND EPIDERMAL GROWTH FACTOR RECEPTOR MUTATION-DRIVEN LUNG TUMORIGENESIS , Hsuan-Pei Lin

SCIENCE-BASED REGULATION OF PHARMACOLOGICAL SUBSTANCES IN COMPETITION HORSES , Jacob Machin

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Home > School of Medicine > Cancer Biology > Dissertations

Cancer Biology Dissertations

Theses/dissertations from 2022 2022.

Characterizing The Post-Translational Modifications Of The Pro-Oncogenic Type Ii Transmembrane Serine Protease Tmprss13 , Carly Elizabeth Martin

Xpo1 As A Therapeutic Target In Gastric Cancer , Rachel Sexton

Theses/Dissertations from 2021 2021

Therapeutic Dual-Targeting Of Cytosolic And Mitochondrial One-Carbon Metabolism , Aamod Sanjeev Dekhne

Clinical Significance, Functional Role And Molecular Mechanism Of 2’-O-Methyltransferase Ftsj3 In Promoting Cancer Progression , Morenci Manning-Powell

Pak4-Nampt Dual Inhibition As A Novel Strategy For Therapy Resistant Pancreatic Neuroendocrine Tumors , Gabriel Benyomo Mpilla

Targeting Metabolic Vulnerabilities In Epithelial Ovarian Cancer Via Folate Transporters , Adrianne Wallace-Povirk

Theses/Dissertations from 2020 2020

The Role Of Bca2 In Regulation Of Warburg-Like Glucose And Lactate Metabolism In Breast Cancer Cell Lines , Richard T. Arkwright Iii

Apobec3 Enzymes Mediate Efficacy Of Cisplatin And Carboplatin Through The Activation Of Base Excision Repair And Mismatch Repair , Kayla Conner

Evaluation Of Autoantibodies To Paraneoplastic Antigens As Early Detection Biomarkers For High-Grade Serous Ovarian Cancer , Laura Catherine Hurley

A Novel Target Of Hdac6’s E3 Ubiquitin Ligase Activity, Chk1, Is Responsible For The Sensitization Of Non-Small Cell Lung Cancer Cells To Ionizing Radiation , Niko Moses

Theses/Dissertations from 2019 2019

Sprouty4 Is A Negative Regulator Of Erk/mapk Signaling In Breast Cancer And Plays A Role In The Transition From In Situ To Invasive Disease , Ethan Brock

Novel Insights Into The Use Of Ercc1 As A Biomarker For Response To Platinum-Based Chemotherapy In Lung Cancer , Joshua Ryan Heyza

Strategies To Enhance The Anti-Leukemic Activity Of Venetoclax (abt-199) In Aml Through Targeting Of Mcl-1 , Daniel Luedtke

Utilizing Immunopet To Measure Tumor Response To Treatment In Breast Cancer , Brooke Mcknight

Investigation Of The Role For Methyl-Cpg Binding Protein 2 Variant Mbd2_v2 In Cancer Stem Cells And Obesity-Associated Cancers , Emily A. Teslow

Theses/Dissertations from 2018 2018

Identifying The Role Of The Type-Ii Transmembrane Serine Protease Tmprss13 In Breast Cancer , Andrew Stevan Murray

Characterizing Novel Radiologic And Pathologic Tissue-Based Risk Factors For Breast Cancer In African American Women With Benign Breast Disease , Asra N. Shaik

Theses/Dissertations from 2017 2017

Pet Imaging Of Early Therapeutic Response In Solid Tumors , Stephanie J. Blocker

The Effects Of Bone Marrow Adipocytes On Metabolic Regulation In Metastatic Prostate Cancer , Jonathan Diedrich

Preparation And Utility Of Polymeric Nanoparticles For The Delivery Of Sirna As Cancer Therapy , Daniel Paul Feldmann

Functional Analysis Of Rad6 In Brca1 Wild Type And Brca1 Mutant Triple Negative Breast Cancer Drug Response , Brittany Haynes

Clinicopathology And Molecular Determinants Underlying Benign Breast And Breast Cancer Lesions , Andreana Holowatyj Holowatyj

Folate Receptor Alpha Targeted Delivery And Characterization Of Polyethyleneimine-Graft-Polycaprolactone-Block-Poly(ethylene Glycol) Containing Sirna Micelleplexes , Steven Jones

Mechanisms Of Hormonal Regulation Of Invasiveness And Metastasis Of Luminal Breast Cancer , Thomas Mcfall

New Mechanism Based Approaches For Treating Prostate Cancer , Rayna Rosati

Functions Of Atr/mec1 In Meiosis And The Cell Cycle , Layne Weatherford

Theses/Dissertations from 2016 2016

Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia , John Timothy Caldwell

Whsc1l1 Regulates Estrogen Receptor Activity In Sum44 Breast Cancer Cells , Jonathan Curtis Irish

Imaging Anti-Proliferative Compounds With Flt-Pet , Christopher Mchugh

Loss Of Rap1gap: A Driver In The Progression From Dcis Of The Breast To Idc , Seema Shah

Structural Characterization And Therapeutic Utility Of The Proton-Coupled Folate Transporter , Michael Roy Wilson

Theses/Dissertations from 2015 2015

Therapeutic Targeting Of Bmp2 In Nf1-Deficient Malignant Peripheral Nerve Sheath Tumors (mpnsts) , Sidra Ahsan

Hrd1 Partners In Endoplasmic Reticulum-Associated Degradation , Aaron Alexander Burr

Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin , Aimalie Lynnette Hardaway

The Therapeutic Targeting Of Folate Receptor Alpha Positive Tumors Via Folate Receptor Selective Novel 5- And 6- Substituted Pyrrolo [2,3-D]pyrimidine Antifolates" , Shermaine Kimberly Mitchell-Ryan

Theses/Dissertations from 2014 2014

The Tumor-Suppressive Role Of Secreted Maspin Via The Exosomes , Ivory Dean

Combating Resistance To Epidermal Growth Factor Recpetor Inhibitors In Triple Negative Breast Cancer , Julie Marie Madden

Tmprss2-Erg Regulation Of Androgen Biosynthetic Enzyme Expression, Dht Synthesis, And Androgen Receptor Activation In Prostate Cancer , Katelyn Ann Powell

Pathway Profiling Of Replicative And Induced Senescence , Maggie Purcell

Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways , Sara M. Schmitt

A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk , Elizabeth Tovar

Matriptase Mediated C-Met Signaling In Breast Cancer , Gina Lynn Zoratti

Theses/Dissertations from 2013 2013

The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection , Daniela (buac) Ventro

Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity , Kelly Haagenson

Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma , Jennifer M. Rothberg

Impact Of Cryoablation On Tumor Immunity , Jesse Veenstra

Analysis Of The Structure And Function Of A Timp-1/cd63 Complex And Its Relationship To An Mt1-Mmp/cd63 Complex , Richard B. Warner

Theses/Dissertations from 2012 2012

The proton-coupled folate transporter: biology and therapeutic applications to cancer , Sita Desmoulin

Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression , Prasanna Ekambaram

A Role For Reactive Oxygen Species In Photodynamic Therapy , Michael Price

Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma , Angela Sosin

Theses/Dissertations from 2011 2011

Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking , Andrea Jacqueline Baillo

Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer , Bernadette Caroline Victor

Theses/Dissertations from 2010 2010

Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression , M. Katie Conley-Lacomb

Regulatory And Functional Aspects Of Foxo3a Transcription Factor And Their Implications In Prostate Cancer , Melissa Elise Dobson

Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling , Christina Downey

Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention , Michael Joseph Frezza

Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia , Amanda Larson Gedman

Creg1 And Its Enhancement Of P16ink4a-Induced Senescence , Benchamart Moolmuang

Theses/Dissertations from 2000 2000

Proteasome inhibitor induced apoptosis in THP-1 cells , Catheryne. Chen

Neutropenia : In Vitro Predictions of In Vivo Endpoints , Kristan A. Keyes

Regulation of arachidonate 12-lipoxygenase and its role in tumor cell alpoptosis , Keqin. Tang

Differentiation of malignant human B-cell acute lymphoblastic leukemia , Nathan R. Wall

Theses/Dissertations from 1999 1999

Rac1-induced invasion : intracellular proteolysis of the extracellular matrix , Mamoun. Ahram

Structural and functional relationship of a galactoside-binding protein---galectin-3 , Hua Chang Gong

Tumor therapeutic response detected by nuclear magnetic resonance diffusion measurement , Zhanquan. He

Cathepsins B and D in human breast fibroblasts and epithelial/carcinoma cells , Jennifer E. Koblinski

A molecular biological study of the 3P- syndrome galectin-3 gene expression and the physical interaction between ER{45}R and P53 in breast cancer , Guozhen Liu

Theses/Dissertations from 1998 1998

Isolation and characterization of a common nuclear matrix protein and other studies , Tracy Sue Schwab

Theses/Dissertations from 1997 1997

Absolute tumor perfusion determined by nuclear magnetic resonance spectroscopy : , Nicholas Edward Simpson

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Cancer Research (MS)

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Dr. Joyce Solheim (Chair & Program Director), Dr. Tadayoshi Bessho, Dr. Jennifer Black, Dr. Pi-Wan Cheng, Dr. Babu Guda, Dr. Keith Johnson, Dr. Xu Luo, Dr. Aaron Mohs, Dr. Youri Pavlov, Dr. Angie Rizzino, and Dr. Pankaj Singh

Scientists with Master of Science degrees can make many important contributions related to cancer, which is a very widespread and often deadly disease.  Students have the option of obtaining a Cancer Research MS degree after writing a research thesis (Thesis Option) or without a research thesis (Non-Thesis Option).  Graduates with the UNMC Cancer Research MS degree have taken positions in personalized medicine counseling, in management of research laboratories, and in directing community-based health projects.  

General Requirements

• Completion of at least 30 semester credits beyond the bachelor's degree, including both lecture coursework and research credits 
• Completion of coursework
•  Completion of the comprehensive examination
•  Completion of a research project consistent with a master's level achievement
•  Completion and successful defense of a master's thesis (Thesis Option only)

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Master's Theses

Tumor immunology: understanding the immune system and cancer to enhance the efficacy of cancer immunotherapies.

Natasha Malibu Lenart Follow

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Degree type, degree name.

Master of Science (MS)

Molecular Biology

Tumor cells are notorious for their ability to escape immune surveillance, but developments in the understanding of the tumor microenvironment and how the immune system can be re-activated in tumors have had significant clinical impact. Commercially available and experimental methods such as adoptive cellular therapy, cytokine stimulation, and immune checkpoint blockade are promising immunotherapies for a variety of cancers, including solid tumors and hematological malignancies. However, induction of persistent, long-term anti-tumor immunity after initial treatment is infamously difficult. as a result, scientists are searching for new approaches to improve established immunotherapies. by employing combination treatments or enhancing the functionality of cellular products prior to infusion, patients may experience better clinical outcomes through the development of more effective immunotherapies. This thesis reviews the function of the immune system in the tumor microenvironment and discusses how this knowledge is used within the field of tumor immunology to develop and enhance immunotherapy models.

Recommended Citation

Lenart, Natasha Malibu, "Tumor Immunology: Understanding the Immune System and Cancer to Enhance the Efficacy of Cancer Immunotherapies" (2020). Master's Theses . 4339. https://ecommons.luc.edu/luc_theses/4339

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2024-25 Academic Catalog

Master of science in cancer biology.

The Master of Science (M.S.) program in Cancer Biology prepares the student for a career at the advanced technical level in academia, industry, or government. Graduating students may also find teaching positions at the secondary or junior college level. 

The application process is an online process. Application to this graduate program is facilitated through the Interdisciplinary Graduate Program in Biomedical Sciences (IGPBS). Detailed instructions on how to apply and the application deadlines are posted on the Interdisciplinary Graduate Program in Biomedical Sciences website http://www.kumc.edu/igpbs/how-to-apply.html .

Admission Requirements:

• Bachelor’s degree from a regionally accredited institution documented by submission of official transcript indicating the degree has been conferred before entering the program. Official transcripts from institutions attended post-baccalaureate are also required. Students with degrees from outside the U.S. may be subject to transcript evaluation indicating the degree is equivalent to a U.S. degree and meets the minimum cumulative GPA requirements.
• A cumulative grade-point average (GPA) of at least a 3.0 on a 4.0 scale for the bachelor’s degree.
• Applicants who are not native speakers of English, whether domestic or international, must demonstrate they meet the Minimum English Proficiency Requirement .
• A background check is required during the admission process; it may affect the student's eligibility to enter the program.
• Three letters of recommendation.
• One year of general chemistry
• One year of organic chemistry or one semester of organic chemistry and one semester of biochemistry
• One year of biological sciences
• One semester of calculus
• One semester of physics
• Research experience (beyond labs associated with lecture courses) is strongly suggested.

Applicants will be assessed based on a combination of GPA, and research experience. Students not meeting the above requirements may be eligible for provisional admission.  After an applicant has been admitted, a program may defer an applicant's admission for one year after which time the applicant must submit a new application.

Admission requirements are subject to change. In most cases, use the catalog of the year student entered the program. Other years’ catalogs ».

The Master of Science (M.S.) program in Cancer Biology prepares the student for a career at the advanced technical level in academia, industry, or government.

Degree requirements:

• Degree requirements are normally completed within 3 years of admission to the program although a maximum of 7 years is allowed.
• Completion of a minimum of 30 credit hours.
• Cumulative grade-point average (GPA) of at least a 3.0 for all KU graduate coursework.
• Enrollment in a minimum of one (1) credit hour of  CBIO 899 Master's Thesis in Cancer Biology the semester the student will defend the thesis and graduate.
• Successful completion of the thesis defense  or general examination the semester the student will graduate. The thesis should be comparable in scope to justify co-authorship on a rigorously peer-reviewed manuscript.  In general, CBIO students graduating with an MS degree should have justified co-authorship on at least one peer-reviewed publication (as determined by their thesis advisory committee).
• Successful Thesis Submission and Publication (according to Office of Graduate Studies policy.)

• Successful completion of  PATH 913 Introduction to Grant Proposal Writing .

• Continued attendance at the KUCC seminar (minimum 75% required determined by sign-in) in both the Fall and Spring semesters after completing 5 semesters of CBIO 850 Cancer Center Seminar .
• Annual presentation and continued attendance at Communicating Cancer Science in both the Fall and Spring semesters after completing 5 semesters of CBIO 860 Communicating Cancer Science .
• Annual participation and/or attendance at the KU Medical Center Student Research Forum.
• Annual participation and/or attendance at the KU Cancer Center Research Retreats.

Degree requirements and course descriptions are subject to change. Any courses taken as an equivalent must be approved by the Graduate Director and the Office of Graduate Studies. In most cases, use the catalog of the year student entered the program.    Other years’ catalogs ».

Typical Plan of Study

TECHNICAL STANDARDS AND REQUIREMENTS FOR THE M.S. IN CANCER BIOLOGY

The M.S. degree signifies that the holder is prepared for entry into research in industrial or academic laboratory settings. To that end, graduates must have the knowledge and skills to function in a broad variety of laboratory settings.

• Observation: The candidate must be able to observe demonstrations and experiences in the basic sciences, including but not limited to biology demonstrations in animals, cultures, and microscopic studies of tissues in normal and pathologic states. A candidate must be able to observe and analyze experimental detail. Observation necessitates the functional use of the sense of vision and somatic sensation.
• Communication: A candidate should be able to communicate, to understand, and to observe lectures and laboratory instruction. A candidate must be able to communicate effectively in order to present and analyze research data. Communication includes not only speech, but also reading and writing. The candidate must be able to communicate effectively and efficiently in oral and written form with students, staff, and faculty.
• Motor: Candidates should have sufficient motor function to carry out lab techniques. A candidate should be physically able to do laboratory procedures and analyze data. Such actions require coordination of both gross and fine muscular movements, equilibrium, and functional use of the senses of touch and vision.
• Intellectual-Conceptual, Integrative, and Quantitative Abilities: The abilities include measurement, calculation, reasoning, analysis, and synthesis. Problem solving, the critical skill demanded of scientists, requires all of these intellectual abilities. In addition, the candidate should be able to comprehend three-dimensional relationships and to understand the spatial relationships of structures.
• Behavioral and Social Attributes: A candidate must possess the emotional health required for full utilization of his/her intellectual abilities, the exercise of good judgment and the prompt completion of all responsibilities attendant to the completion of research and teaching responsibilities. Integrity and motivation are personal qualities, which are required for success in science.

Disabled individuals are encouraged to apply. Applicants whose response indicates that they cannot meet the expectations will be reviewed by the Graduate Committee and Technical Support staff of KUMC to assess the extent of the student’s difficulties. At this review the provisions for reasonable accommodation will be determined.

For further information, contact the Department of Cancer Biology, University of Kansas School of Medicine, 2003 Wahl Hall West, 3901 Rainbow Blvd., Kansas City, Kansas 66160 (Phone: (913) 945-7739 E-mail: [email protected]

STUDENT POLICY ON INFECTIOUS DISEASE

Due to the need to assure the health and safety of students, faculty, and staff, the fact that an applicant for admission has an infectious disease or is the carrier of an infectious disease may be a factor in determining eligibility for academic program admission at the University of Kansas Medical Center. Determination of eligibility for admission in such cases will be made on an individual basis in consultation with the applicant’s physician, taking into consideration (among other factors), legal requirements and the current best medical information available to determine whether the applicant could complete the normal course of study with reasonable accommodation and without risk to him/herself or to others. Therefore, applicants having an infectious disease or who are carriers of an infectious disease must advise the Graduate Committee of this fact and may be required to provide medical records for review by the Student Health Physician in order to determine eligibility for admission.

DRUG FREE WORKPLACE POLICY OF THE UNIVERSITY OF KANSAS

It is the policy of the University of Kansas that unlawful manufacture, distribution, dispensing, possession, or use of controlled substances or alcohol is prohibited in buildings, facilities, or grounds controlled by the University. Any student found to be illegally manufacturing, distributing, dispensing, possessing, or using controlled substances or alcohol at the University or any of its affiliated educational sites, shall be subject to disciplinary action in accordance with applicable policies as outlined in the Graduate Student Handbook . Students are reminded that illegal manufacture, distribution, dispensing, possession, or use of controlled substances may also subject individuals to criminal prosecution.

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2024-25 Entire Catalog

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Wayne State University

School of medicine, cancer biology program cancer biology program, master of science in cancer biology, master of science  cancer biology graduate program department of oncology (updated 10-16-2023), program description, the master of science (ms) program in cancer biology offers a strong didactic and laboratory curriculum in cancer biology with a major focus on molecular oncology. our goal is to provide intensive research training for students who are interested in a career in academia, medicine, industry, or related careers in which first-hand research experience is an asset. research interests in the department of oncology are diverse, allowing students to choose from a broad spectrum of topics for their research thesis. students are encouraged to attend monthly research seminars, along with karmanos cancer institute-sponsored research meetings and symposia.  these regular interactions between students and faculty help our students develop oral communication and collaboration skills for future success., degree requirements, the master's degree in cancer biology is offered under plan a only. a minimum of 30 credits (eight of which must be from thesis research) and the completion of an original research project including a written master’s thesis are required to complete the requirements for the ms degree in cancer biology. the coursework includes 17 credits of compulsory courses and 5 credits of elective courses (below). a minimum gpa of 3.0 must be maintained throughout the ms program. students are required to complete two laboratory rotations by the second semester of year 1 of study in order to have a thesis advisor in place for beginning full time thesis research. the student and mentor should identify two additional faculty members to serve on the thesis committee. students should strive to publish one peer-reviewed paper in connection with the ms research., plan a curriculum (total 30 cr.), required courses (17 cr.):, mgg 7010 molecular biology & genetics (4 cr.) fall semester. bio 6000 molecular cell biology i (3 cr.) fall semester. cb 7210 fundamentals of cancer biology (3 cr.) winter semester. cb 7500 ms biostatistics (2 cr.) winter semester. cb 7510 - journal club/seminar ms, winter semester only (1 cr./ winter semester). total of 2 cr. over the course of the program. cb 7710 rotation (2 cr.) fall semester cb 7800 ethics (1 cr.) winter semester cb 8999 master’s thesis research (8 cr), elective courses (5 cr.): in addition to the courses listed above, students are allowed to select appropriate courses from other departments/programs across the campus., cb 7300 special topics (1-4 topics, 1 cr.) phc 7650 (1-4 topics, 1 cr.) psl 7880 special problems (1 cr.) admission requirements, admission to the ms program is contingent upon admission to the graduate school and the graduate programs of the  school of medicine . qualified applicants must have a bs or ba degree from an accredited college or university, preferably with a major in biology, chemistry, physics, or a closely related discipline. a complete application includes the basic application form, personal statement, official transcripts from previous institutions, and three letters of reference.  international students must be proficient in english (as determined by satisfactory performance on the test of english as a foreign language (toefl) examination). toefl scores should be reported to wayne state university using institution code 1898. applications must be submitted online by april 1 st . graduate school admissions policies can be found at the  office of graduate admissions., contact information, administrative office for ms program in cancer biology department of oncology wayne state university school of medicine 421 e canfield street detroit, mi 48201, tel: 313-578-4302 email: [email protected].

MSc by Research in Oncology

• Entry requirements
• Funding and Costs

College preference

• How to Apply

About the course

This programme aims to train the next generation of leaders in translational oncology research by applying state-of-the-art techniques to address fundamental biology of cancer and how to optimise treatments for patients. 

The Department of Oncology employs multidisciplinary approaches from physics, biology, chemistry and mathematical modelling to investigate DNA biology and epigenetics, cell and environmental biology of tumour tissue and both systemic and local immunological responses in cancer. The programme focuses on expanding scientific knowledge with a particular focus on therapies involving drug discovery or action and combination therapies with radiotherapy.

The MSc by Research in Oncology course accepts students for one to three years of study, however, the majority of students in this department complete their project in a year. Applications are accepted from both basic scientists and clinicians.

In the first instance interested applicants are advised to review the department’s website to identify potential supervisors based on their research area of interest. Selecting the correct research projects is a hugely important first step so it is recommended that you contact a potential supervisor directly to discuss possibilities. Each researcher has their own profile page with their contact details listed.

Pattern of teaching and learning

This course does not include a timetable of lectures but there is a wide range of courses and workshops you will be able to attend to acquire skills that will be necessary for the pursuance and presentation of your research, as well as your professional development as a research scientist. The Department of Oncology provides an induction to the department in the first weeks of study and encourages attendance at divisional and University induction events. 

You will be encouraged to make the most of the doctoral training and research methods provision available across the Medical Sciences Division and to attend departmental and divisional seminars. As an MSc by Research student you will be given the opportunity to present your work at a variety of seminars and sessions in the department. 

You will be encouraged to attend training opportunities that include both subject-specific and generic research and transferable skills.

The course is full-time and requires attendance in Oxford. Full-time students are subject to the University's Residence requirements.

Provision exists for students on some courses to undertake their research in a ‘well-founded laboratory’ outside of the University. This may require travel to and attendance at a site that is not located in Oxford. Where known, existing collaborations will be outlined on this page. Please read the course information carefully, including the additional information about course fees and costs. 

Resources to support your study

As a graduate student, you will have access to the University's wide range of world-class resources including libraries, museums, galleries, digital resources and IT services.

The Bodleian Libraries is the largest library system in the UK. It includes the main Bodleian Library and libraries across Oxford, including major research libraries and faculty, department and institute libraries. Together, the Libraries hold more than 13 million printed items, provide access to e-journals, and contain outstanding special collections including rare books and manuscripts, classical papyri, maps, music, art and printed ephemera.

The University's IT Services is available to all students to support with core university IT systems and tools, as well as many other services and facilities. IT Services also offers a range of IT learning courses for students, to support with learning and research.

Students are provided with laboratory workspace, desk space and IT facilities in support of their research. In addition there are on-site library and social facilities.

Supervision

You will be admitted directly to a particular research area led by a Principal Investigator who will be appointed your supervisor. You will be based in a research lab and undertake research on a subject agreed with your supervisor. All MSc by Research candidates are assigned two supervisors in total, one acting as the main day-to-day research supervisor and the second as an additional academic mentor.

The allocation of graduate supervision is the responsibility of the Department of Oncology and it is not always possible to accommodate the preferences of incoming graduate students to work with a particular member of staff.

Students will normally have two strands of supervision and the support of the Director of Graduate Studies, as well as administrative support within the department. Students can expect to meet with their supervisors several times each month, depending upon the requirements of their research project.

Assessment for this master's degree course is by submission of a thesis and a viva with two examiners.

You will begin your course as a probationary research student (PRS). Towards the end of your first year you will apply to transfer to “MSc by Research” status. To transfer your status, you must apply formally, submit a research report and statement of future research plans, and take an independent assessment by two assessors. Progression on the course is dependent upon passing the Transfer of Status assessment.

Following successful completion of the transfer assessment then candidates will progress and are able to submit their thesis prior to examination by viva.

Graduate destinations

Many graduates have progressed to PhD/DPhil positions either at Oxford or at other UK or international universities.

Changes to this course and your supervision

The University will seek to deliver this course in accordance with the description set out in this course page. However, there may be situations in which it is desirable or necessary for the University to make changes in course provision, either before or after registration. The safety of students, staff and visitors is paramount and major changes to delivery or services may have to be made if a pandemic, epidemic or local health emergency occurs. In addition, in certain circumstances, for example due to visa difficulties or because the health needs of students cannot be met, it may be necessary to make adjustments to course requirements for international study.

Where possible your academic supervisor will not change for the duration of your course. However, it may be necessary to assign a new academic supervisor during the course of study or before registration for reasons which might include illness, sabbatical leave, parental leave or change in employment.

For further information please see our page on changes to courses and the provisions of the student contract regarding changes to courses.

Entry requirements for entry in 2025-26

Proven and potential academic excellence.

The requirements described below are specific to this course and apply only in the year of entry that is shown. You can use our interactive tool to help you  evaluate whether your application is likely to be competitive .

We know that factors such as socio-economic circumstances and school performance can make it difficult for students to demonstrate their full potential. This course is taking part in an initiative to use contextual data to help us to better understand your achievements in the context of your individual background. For further details, please refer to the information about improving access to graduate study in the How to apply section of this page.

Please be aware that any studentships that are linked to this course may have different or additional requirements and you should read any studentship information carefully before applying. Contextual data may also be used in the assessment of studentships. 

Degree-level qualifications

As a minimum, applicants should hold or be predicted to achieve the following UK qualifications or their equivalent:

• a first-class or strong upper second-class undergraduate degree with honours in a biological, medical, chemical, mathematical or physical science subject, as appropriate for the projects offered.

However, entrance is highly competitive and most successful applicants have a first-class degree or the equivalent.

For applicants with a bachelor's degree from the USA, the minimum overall GPA that is normally required to meet the undergraduate-level requirement is 3.5 out of 4.0. However, entrance is highly competitive and it is anticipated that most successful applicants will have obtained a GPA of 3.7 or higher.

If your degree is not from the UK or another country specified above, visit our International Qualifications page for guidance on the qualifications and grades that would usually be considered to meet the University’s minimum entry requirements.

GRE General Test scores

No Graduate Record Examination (GRE) or GMAT scores are sought.

Other qualifications, evidence of excellence and relevant experience

• Publications are not required, but they may advantage an application.
• It would be expected that graduate applicants would be familiar with the recent published work of their proposed supervisor.

Further guidance

All students are cleared for security. Non-EU students will require approval from the Academic Technology Approval Scheme (ATAS) for courses at the Department of Oncology.

English language proficiency

This course requires proficiency in English at the University's  standard level . If your first language is not English, you may need to provide evidence that you meet this requirement. The minimum scores required to meet the University's standard level are detailed in the table below.

*Previously known as the Cambridge Certificate of Advanced English or Cambridge English: Advanced (CAE) † Previously known as the Cambridge Certificate of Proficiency in English or Cambridge English: Proficiency (CPE)

Your test must have been taken no more than two years before the start date of your course. Our Application Guide provides further information about the English language test requirement .

Declaring extenuating circumstances

If your ability to meet the entry requirements has been affected by the COVID-19 pandemic (eg you were awarded an unclassified/ungraded degree) or any other exceptional personal circumstance (eg other illness or bereavement), please refer to the guidance on extenuating circumstances in the Application Guide for information about how to declare this so that your application can be considered appropriately.

You will need to register three referees who can give an informed view of your academic ability and suitability for the course. The  How to apply  section of this page provides details of the types of reference that are required in support of your application for this course and how these will be assessed.

Supporting documents

You will be required to supply supporting documents with your application. The  How to apply  section of this page provides details of the supporting documents that are required as part of your application for this course and how these will be assessed.

Performance at interview

Interviews are normally held as part of the admissions process. It is expected that interviews will be scheduled in January and will normally be held by video conference.

Shortlisting meetings to consider applicants for interview include a minimum of two academics and the interview panel includes a minimum of two academics. The format of the interview is a five minute presentation of your research experience or recent scientific project, followed by a question-and-answer session designed to investigate your:

• experience or potential
• knowledge of the field
• interactive skills
• presentation skills
• analytical skills
• experimental design
• scientific motivation
• career plan.

Offer conditions for successful applications

If you receive an offer of a place at Oxford, your offer will outline any conditions that you need to satisfy and any actions you need to take, together with any associated deadlines. These may include academic conditions, such as achieving a specific final grade in your current degree course. These conditions will usually depend on your individual academic circumstances and may vary between applicants. Our ' After you apply ' pages provide more information about offers and conditions . 

In addition to any academic conditions which are set, you will also be required to meet the following requirements:

Financial Declaration

If you are offered a place, you will be required to complete a  Financial Declaration  in order to meet your financial condition of admission.

Disclosure of criminal convictions

In accordance with the University’s obligations towards students and staff, we will ask you to declare any  relevant, unspent criminal convictions  before you can take up a place at Oxford.

Academic Technology Approval Scheme (ATAS)

Some postgraduate research students in science, engineering and technology subjects will need an Academic Technology Approval Scheme (ATAS) certificate prior to applying for a  Student visa (under the Student Route) . For some courses, the requirement to apply for an ATAS certificate may depend on your research area.

Other factors governing whether places can be offered

The following factors will also govern whether candidates can be offered places:

• the ability of the University to provide the appropriate supervision for your studies, as outlined under the 'Supervision' heading in the About section of this page;
• the ability of the University to provide appropriate support for your studies (eg through the provision of facilities, resources, teaching and/or research opportunities); and
• minimum and maximum limits to the numbers of students who may be admitted to the University's taught and research programmes.

The Department of Oncology has an established graduate training programme for science graduates and clinical research fellows under the leadership of Professor Mark Middleton.

It is one of the largest departments in the University of Oxford’s Medical Sciences Division. It houses over 400 staff and graduate students, both clinical and non-clinical, and brings together research and clinical groups from across Oxford who are based at the Old Road Campus Research Building (ORCRB), the Radiobiology Research Institute (RRI), the Weatherall Institute for Molecular Medicine (WIMM) and the NHS Cancer and Haematology Centre.

The Department of Oncology is located in the Old Road Campus Research Building, which includes a large communal atrium containing seating and a cafeteria, and houses the Knowledge Centre, one of the Bodleian Health Care Libraries, which offers workspaces and subject collections.

The department offers promising graduates a broad range of multidisciplinary and translational cancer research projects. As a result, its graduates come from a wide range of scientific backgrounds, including biology, medicine, engineering, mathematics, chemistry, and physics. The department prides itself on supporting and training the next generation of world leaders in cancer research to ensure its research continues over the long term.

The department's ethos is to improve treatment of cancer patients by harnessing Oxford University’s scientific research prowess and translating this into an impactful benefit to cancer patients through our own clinical trials. Working together to achieve this aim, we have renowned experts alongside cutting-edge scientists that collaborate across the university to understand the biology of cancer and how to best adopt new therapeutic strategies in medical and clinical oncology.

Research in the department is focused on the biology of cancer and how to translate discoveries into better treatments for patients. The department research strategy centres around the three core themes of DNA (including DNA damage, repair, and replication), cell and tissue biology (tumour microenvironment), and immuno-oncology (including cancer vaccines and virotherapy). Details of individual research groups  which work within each of these themes can be found on the department website.

Students work alongside and learn from leaders in their field, and are provided with a world- class academic environment. They benefit from excellent support services, including a comprehensive portfolio of personal and professional skills development.

The Medical Sciences Division training opportunities cover all aspects of research-related or technical skills, such as ethics, data analysis and statistics and bioinformatics; communications skills including scientific writing and oral and poster presentations, careers and personal development such as personal effectiveness and career planning; and finally academic practice including grant writing, teaching and intellectual property.

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If you apply by the December deadline shown on this page and receive a course offer, your application will then be considered for Oxford scholarships. For the majority of Oxford scholarships, your application will automatically be assessed against the eligibility criteria, without needing to make a separate application. There are further Oxford scholarships available which have additional eligibility criteria and where you are required to submit a separate application. Most scholarships are awarded on the basis of academic merit and/or potential.

To ensure that you are considered for Oxford scholarships that require a separate application, for which you may be eligible,  use our fees, funding and scholarship search tool  to identify these opportunities and find out how to apply. Alongside Oxford scholarships, you should also consider other opportunities for which you may be eligible including  a range of external funding ,  loan schemes for postgraduate study  and any other scholarships which may also still be available after the December deadline as listed on  our fees, funding and scholarship search tool .

Details of college-specific funding opportunities can also be found on individual college websites:

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Please refer to the College preference section of this page to identify which of the colleges listed above accept students for this course.

For the majority of college scholarships, it doesn’t matter which college, if any, you state a preference for in your application. If another college is able to offer you a scholarship, your application can be moved to that college if you accept the scholarship. Some college scholarships may require you to state a preference for that college when you apply, so check the eligibility requirements carefully.

Further information about funding opportunities for this course can be found on the department's website.

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Information about course fees

Course fees are payable each year, for the duration of your fee liability (your fee liability is the length of time for which you are required to pay course fees). For courses lasting longer than one year, please be aware that fees will usually increase annually. For details, please see our guidance on changes to fees and charges .

Course fees cover your teaching as well as other academic services and facilities provided to support your studies. Unless specified in the additional information section below, course fees do not cover your accommodation, residential costs or other living costs. They also don’t cover any additional costs and charges that are outlined in the additional information below.

Continuation charges

Following the period of fee liability , you may also be required to pay a University continuation charge and a college continuation charge. The University and college continuation charges are shown on the Continuation charges page.

Where can I find further information about fees?

The Fees and Funding  section of this website provides further information about course fees , including information about fee status and eligibility  and your length of fee liability .

Additional information

There are no compulsory elements of this course that entail additional costs beyond fees (or, after fee liability ends, continuation charges) and living costs. However, please note that, depending on your choice of research topic and the research required to complete it, you may incur additional expenses, such as travel expenses, research expenses, and field trips. You will need to meet these additional costs, although you may be able to apply for small grants from your department and/or college to help you cover some of these expenses.

Living costs

In addition to your course fees and any additional course-specific costs, you will need to ensure that you have adequate funds to support your living costs for the duration of your course.

Living costs for full-time study

For the 2025-26 academic year, the range of likely living costs for a single, full-time student is between £1,425 and £2,035 for each month spent in Oxford. We provide the cost per month so you can multiply up by the number of months you expect to live in Oxford. Depending on your circumstances, you may also need to budget for the  costs of a student visa and immigration health surcharge and/or living costs for family members or other dependants that you plan to bring with you to Oxford (assuming that dependant visa eligibility criteria are met).

Further information about living costs

The current economic climate and high national rate of inflation make it very hard to estimate potential changes to the cost of living over the next few years. For study in Oxford beyond the 2025-26 academic year, it is suggested that you budget for potential increases in living expenses of around 4% each year – although this rate may vary depending on the national economic situation. For further information, please consult our more detailed information about living costs , which includes a breakdown of likely living costs in Oxford for items such as food, accommodation and study costs.

Students enrolled on this course will belong to both a department/faculty and a college. Please note that ‘college’ and ‘colleges’ refers to all 43 of the University’s colleges, including those designated as societies and permanent private halls (PPHs). 

If you apply for a place on this course you will have the option to express a preference for one of the colleges listed below, or you can ask us to find a college for you. Before deciding, we suggest that you read our brief  introduction to the college system at Oxford  and our  advice about expressing a college preference . 

If you are a current Oxford student and you would like to remain at your current Oxford college, you should check whether it is listed below. If it is, you should indicate this preference when you apply. If not, you should contact your college office to ask whether they would be willing to make an exception. Further information about staying at your current college can be found in our Application Guide. 

The following colleges accept students on the MSc by Research in Oncology:

• Balliol College
• Exeter College
• Green Templeton College
• Hertford College
• Jesus College
• Keble College
• Kellogg College
• Linacre College
• Lincoln College
• Magdalen College
• New College
• Oriel College
• The Queen's College
• Reuben College
• St Anne's College
• St Catherine's College
• St Cross College
• St Edmund Hall
• St Hilda's College
• St Hugh's College
• St John's College
• St Peter's College
• Somerville College
• University College
• Wadham College
• Wolfson College
• Worcester College
• Wycliffe Hall

Before you apply

We strongly recommend you consult the Medical Sciences Graduate School's research themes to identify the most suitable course and supervisor .

Our  guide to getting started  provides general advice on how to prepare for and start your application.  You can use our interactive tool to help you evaluate whether your application is likely to be competitive .

If it's important for you to have your application considered under a particular deadline – eg under the December deadline in order to be considered for Oxford scholarships – we recommend that you aim to complete and submit your application at least two weeks in advance . Check the deadlines on this page and the  information about deadlines and when to apply  in our Application Guide.

Application fee waivers

An application fee of £20 is payable for each application to this course. Application fee waivers are available for the following applicants who meet the eligibility criteria:

• applicants from low-income countries;
• refugees and displaced persons; 
• UK applicants from low-income backgrounds; and 
• applicants who applied for our Graduate Access Programmes in the past two years and met the eligibility criteria.

You are encouraged to  check whether you're eligible for an application fee waiver  before you apply.

Do I need to contact anyone before I apply?

You should contact a Group Head via the  Oncology website  before you apply in order to arrange either to apply to an open project, or to gain the Group Head's support for an independently written research project.

General enquiries about the course can be directed to the course administrator, via the contact details provided on this page.

Improving access to graduate study

This course is taking part in initiatives to improve the selection procedure for graduate applications, to ensure that all candidates are evaluated fairly.

Socio-economic data (where it has been provided in the application form) will be used as part of an initiative to contextualise applications at the different stages of the selection process.

Completing your application

You should refer to the information below when completing the application form, paying attention to the specific requirements for the supporting documents .

For this course, the application form will include questions that collect information that would usually be included in a CV/résumé. You should not upload a separate document. If a separate CV/résumé is uploaded, it will be removed from your application .

If any document does not meet the specification, including the stipulated word count, your application may be considered incomplete and not assessed by the academic department. Expand each section to show further details.

Proposed field and title of research project

You must enter the project you are applying to under 'Field and title of research project' on the 'Course' tab of the application form.

You should not use this field to type out a full research proposal. You will be able to upload your research supporting materials separately if they are required (as described below).

Proposed supervisor

Under 'Proposed supervisor name' enter the name of the academic(s) whom you would like to supervise your research. 

Referees: Three overall, academic preferred

Whilst you must register three referees, the department may start the assessment of your application if two of the three references are submitted by the course deadline and your application is otherwise complete. Please note that you may still be required to ensure your third referee supplies a reference for consideration.

Academic references are strongly encouraged, though you may use up to one professional reference provided that it is relevant to the course.

Your references will support intellectual ability, academic achievement, motivation and ability to work in a group.

Official transcript(s)

Your transcripts should give detailed information of the individual grades received in your university-level qualifications to date. You should only upload official documents issued by your institution and any transcript not in English should be accompanied by a certified translation.

More information about the transcript requirement is available in the Application Guide.

Statement of purpose/personal statement: A maximum of 500 words

You should provide a statement of your research interests, in English, describing how your background and research interests relate to the programme. If possible, please ensure that the word count is clearly displayed on the document.

It will be normal for students’ ideas and goals to change in some ways as they undertake their studies, but your personal statement will enable you to demonstrate your current interests and aspirations.

The statement should focus on academic or research-related achievements and interests rather than personal achievements and interests.

This will be assessed for:

• your reasons for applying;
• evidence of motivation for and understanding of the proposed area of study;
• the ability to present a reasoned case in English;
• capacity for sustained and focused work; and
• understanding of problems in the area and ability to construct and defend an argument.

Start or continue your application

You can start or return to an application using the relevant link below. As you complete the form, please  refer to the requirements above  and  consult our Application Guide for advice .

Apply Continue application

After you've submitted your application

Your application (including the supporting documents outlined above) will be assessed against the entry requirements detailed on this course page. Whether or not you have secured funding will  not  be taken into consideration when your application is assessed. You can  find out more about our shortlisting and selection process  in our detailed guide to what happens next.

Find out how to manage your application after submission , using our Applicant Self-Service tool.

ADMISSION STATUS

Open to applications for entry in 2025-26

12:00 midday UK time on:

Tuesday 3 December 2024

Latest deadline for most Oxford scholarships Applications may remain open after this deadline if places are still available - see below

A later deadline under 'Admission status'

If places are still available,  applications may be accepted after 3 December . The Admission status (above) will provide notice of any later deadline.

*Three-year average (applications for entry in 2022-23 to 2024-25)

Further information and enquiries

This course is offered by the Department of Oncology

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Advice about contacting the department can be found in the How to apply section of this page

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Application guide

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Advancement in the detection and treatment of cancer continues to accelerate through ground-breaking research, yet cancer remains one of the most complex and challenging problems of biomedical research.

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A BAYESIAN CONVOLUTIONAL NEURAL NETWORK BASED CLASSIFIER TO DETECT BREAST CANCER FROM HISTOPATHOLOGICAL IMAGES AND UNCERTAINTY QUANTIFICATION

Pushkar Khairnar , Michigan Technological University Follow

Date of Award

Document type.

Campus Access Master's Thesis

Degree Name

Master of Science in Mechanical Engineering (MS)

Administrative Home Department

Department of Mechanical Engineering-Engineering Mechanics

Susanta Ghosh

Committee Member 1

Shiva Rudraraju

Committee Member 2

Benjamin W. Ong

Breast cancer is the most common cause of cancer in women. Histopathological imaging data can provide important information on cancer since it preserves the underlying tissue architecture in the preparation process. Accurate and automated classification of breast tissue into malignant or healthy from histological images can be used for the diagnosis of breast cancer. However, publicly available labeled histopathological datasets are limited in size and also biased. For such datasets, existing machine learning classifiers have shown limited success. The goal of the present work is to develop a classification technique using machine learning, which can overcome the challenge posed by small and biased datasets. This technique will reduce the inaccuracy of the image analysis, and quantify the uncertainty in their prediction.

The field of computer vision and neural networks are aimed at improving the accuracy of image analysis by various network architectures on algorithms. Plain feed-forward neural networks have been successfully used for pattern recognition, but their performance is good only when the data is sufficiently large. When the data size is limited, neural networks yield erroneous or overfitted results, since they don't take the uncertainty of the dataset into account. These feed-forward neural networks learn their weights as point estimates or a deterministic value. Whereas, a Bayesian neural network learns a probability distribution on the weights. The loss function used in Bayesian neural networks is known as a Variational Free Energy (VFE) or Evidence Lower Bound (ELBO) which is to be optimized. Since the Bayesian approach provides probability distributions on the weights of the neural networks, it is possible to calculate the variance of the predictive posterior probability distribution, which is the sum of aleatoric and the epistemic uncertainty. Uncertainty quantification, along with the point estimate, leads to a more informed decision, improved accuracy, and reduced overfitting. In critical applications, especially medical-imaging applications, uncertainty quantification can potentially reduce the unexpected and incorrect results due to the poor decisions. In this thesis, we have worked on the application of Bayesian neural networks on publicly available histopathological images for the detection of breast cancer and uncertainty quantification of the prediction. We have demonstrated that using the Bayesian CNN, the false-negative predictions can be reduced remarkably, by almost 22%. We have found that the predictions associated with higher epistemic uncertainties have features of both the classes. These findings should improve the state of the art machine learning-based biomedical imaging.

Recommended Citation

Khairnar, Pushkar, "A BAYESIAN CONVOLUTIONAL NEURAL NETWORK BASED CLASSIFIER TO DETECT BREAST CANCER FROM HISTOPATHOLOGICAL IMAGES AND UNCERTAINTY QUANTIFICATION", Campus Access Master's Thesis, Michigan Technological University, 2020.

https://doi.org/10.37099/mtu.dc.etdr/1066

Since September 03, 2020

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PERFLUOROALKYL SUBSTANCES (PFAS) INDUCED THERAPY RESISTANCE IN OVARIAN CANCER AND INTERVENTION VIA PHOTOCHEMICAL TARGETING OF MITOCHONDRIA

Add to collection, downloadable content.

• Affiliation: School of Medicine, Curriculum in Toxicology
• One of the main contributors to the lethality of ovarian cancer is resistance tochemotherapy, which occurs in ~85% of patients. Chemotherapy resistance can be innate or canresult from internal (i.e. ascites) or external (i.e. environmental contaminants) exposures.Perfluoroalkyl substances (PFAS) are widespread environmental contaminants that pollutedrinking water supplies worldwide. These chemicals have been linked to adverse reproductivehealth effects in women, including infertility. In a study evaluating the effects of short-term (48-hour) PFAS exposure on ovarian cancer cell chemotherapy response, several PFAS and PFASmixtures were associated with increased survival post-carboplatin treatment, indicative ofchemotherapy resistance. A concomitant increase in mitochondrial membrane potential (ΔΨm)was also observed, suggestive of a mitochondrial mode of action for PFAS-inducedchemoresistance. Impacts of PFAS on mitochondrial functioning were further explored in astudy comparing the effects of short-term, long-term (144-hour), and chronic (26-day) PFASexposures. After long-term exposure, the production of superoxide significantly increased.Significant increases in chemotherapy resistance and ΔΨm were observed in ovarian cancer cellsthat were chronically exposed to PFAS, compared to short-term exposures. These findingsimplicate mitochondria as potential targets of PFAS exposure in ovarian cancer cells.Photodynamic priming (PDP) is a light-based treatment approach that has shown promise in thecontext of ovarian cancer. Importantly, photosensitizers used for PDP, such as aminolevulinic acid-induced protoporphyrin IX (ALA-PpIX) or benzoporphyrin derivative (BPD) are, in part,synthesized in or preferentially localize to, mitochondria. Subsequent light activation leads to theproduction of reactive molecular species and localized photodamage, including to themitochondrial membrane. In ovarian cancer cells exposed to short-term PFAS, treatment witheither BPD- or ALA-PpIX-PDP in combination with carboplatin significantly reduced survivalin all groups where chemotherapy resistance was observed. ΔΨm also decreased significantly inPFAS-exposed ovarian cancer cells treated with mitochondria-associated PDP, suggesting thatdiminishing mitochondrial health is key to overcoming PFAS-induced chemotherapy resistance.Collectively, these data highlight the ability of PFAS to alter response to chemotherapy inovarian cancer cells, propose the mitochondrion as a target of PFAS-induced effects, anddemonstrate the efficacy of mitochondria-associated PDP as a therapeutic approach to overcomeenvironmental contaminant-induced chemotherapy resistance.
• Photodynamic therapy
• Mitochondria
• Chemotherapy resistance
• Ovarian cancer
• https://doi.org/10.17615/sfe1-mx20
• Dissertation
• In Copyright - Educational Use Permitted
• Rizvi, Imran
• Fenton, Suzanne E
• Fry, Rebecca C
• Bae-Jump, Victoria L
• Kenny, Hilary A
• Doctor of Philosophy
• University of North Carolina at Chapel Hill Graduate School

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This guide is designed to help you understand the process of Library formatting review.

A key part of completing your thesis, project, or dissertation focuses on ensuring it is compliant with the standards of your academic department, college, and the University.  

The review team will be certifying that the following steps are completed before signing off on your thesis, project or dissertation, so before coming to your review appointment, make sure that you’ve completed the following:

• All content is aligned to the correct margins.
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• A ll content should be double-spaced throughout.
• If your document includes images, and you are not the original owner of those images, make sure they are all correctly cited (you may need to ask your advisor on which citation style is preferred in your discipline).
• Yo ur document includes the following required preliminary pages: title & committee membership page, abstract page, table of contents, list of tables and figures (if you have them), and references.
• Title and Committee Membership page should be formatted according to the guidelines listed in the sample guide located in the  Graduate Studies checklist on step #5.
• Verify that the table of contents, list of tables, and list of figures are accurate.

It is expected that prior to your meeting with the format review team, you have reviewed the Grad Studies Checklist . A meeting with the format review team will not be scheduled until it is evident that you have done so.

Tips : How to make sure your paper is meeting the requirements? In MS Word Doc. please have your final paper and the sample guide side-by-side and compare them page by page. This will help you on how your paper formatting should look. In addition , take a look at the Sequence of Parts for the order of your preliminary  pages.  Warning : please do not use google doc and/or Microsoft 365 to format your paper. Please download the Micrsoft 365 to your computer. Please see IT in how to do that. 

Don't know what to expect when you make an appointment with a library reviewer?  

The steps/timeline tab includes a guide that will help Graduate Students who are working on their thesis or project with their submissions. Guideline includes:  A Checklist step by step to complete your submission, formatting rules, and what to do next to submit to graduate studies.

All the information on this guide is provided by graduate studies office website.

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There are two new updates on the formatting sample guide. Margins are now 1" inch all around throughout the entire paper. In addition, the signature page has been renamed to committee membership and there are some few changes that has been made please see the sample guide for instructions. 

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Sept 24 – Master of Science Thesis Defence – Antor Mahmud

Thursday, September 19, 2024 | By jsteepe

Master of Science thesis defence in Computer Science

Antor Mahmud, a Master of Science candidate in the Department of Computer Science, will defend his thesis titled “Privacy-Preserving Federated Learning on Knowledge Graph Embeddings via Contrastive Alignment ” on Tuesday, September 24 at 10 AM., in PL600F.

The examination committee includes Naser Ezzati-Jivan, Chair; Renata Queiroz Dividino, Supervisor; Glaucio H.S. de Carvalho, External Examiner (Brock University); and Brian Ross and Robson de Grande, Committee Members.

Tags: Computer Science , FMS , Thesis defence Categories: Events

FMS News and Events

• Sept 25 – Doctoral Thesis Defence – Jae Jung
• Sept 24 – Master of Science Thesis Defence – Antor Mahmud
• Sept 23 – Master of Science Thesis Defence – Reza Miry
• Sept 20 – Master of Science Thesis Defence – Nicole Brauch
• Sept 18 – Master of Science Thesis Defence – Assmaa El Khal
• Sept 16 – Master of Science Thesis Defence – Lasith Chamindu Pranath Pussella
• Sept 13 – Master of Science Thesis Defence – Raissa Sultana
• Sept 11 – Master of Science Thesis Defence – Anuththara Sarathchandra Lekamalage
• Sept 9 – Master of Science Thesis Defence – Alex Popescu
• Aug 29 – Doctoral Thesis Defence – Mahdieh Gol Bashmani

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