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A randomised, two-arm (1:1 ratio), double blind, placebo controlled phase III trial to assess the efficacy, safety, cost and cost-effectiveness of Rituximab in treating de novo or relapsing NS in patients with MCD/FSGS (TURING)

Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS) are a spectrum of disease causing the nephrotic syndrome (NS), characterised by proteinuria with debilitating oedema, as well as a hig...

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Research progress on miR-124-3p in the field of kidney disease

MicroRNAs (miRNAs) are 18–25 nucleotides long, single-stranded, non-coding RNA molecules that regulate gene expression. They play a crucial role in maintaining normal cellular functions and homeostasis in orga...

Correction: Prevalence and risk factors for chronic kidney disease of unknown cause in Malawi: a cross-sectional analysis in a rural and urban population

The original article was published in BMC Nephrology 2020 21 :387

Association between lipoprotein (a) and risk of atherosclerotic cardiovascular disease events among maintenance hemodialysis patients in Beijing, China: a single-center, retrospective study

Serum lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) in the general population, its association with ASCVD incidence in Chinese maintenance hemodialysis...

Correction: expression and significance of Fractalkine/ CX3CL1 in MPO-AAV-associated glomerulonephritis rats

The original article was published in BMC Nephrology 2024 25 :211

Kidney and cardiovascular-protective benefits of combination drug therapies in chronic kidney disease associated with type 2 diabetes

Given the substantial burden of chronic kidney disease associated with type 2 diabetes, an aggressive approach to treatment is required. Despite the benefits of guideline-directed therapy, there remains a high...

Hemoadsorption therapy for myoglobin removal in rhabdomyolysis: consensus of the hemoadsorption in rhabdomyolysis task force

Rhabdomyolysis describes a syndrome characterized by muscle necrosis and the subsequent release of creatine kinase and myoglobin into the circulation. Myoglobin elimination with extracorporeal hemoadsorption h...

What is the best predictor of mortality in patients with type 2 diabetes and chronic kidney disease: mean, variability of HbA1c or HbA1c-Hemoglobin ratio?

Limitations in the measurement of glycated hemoglobin (HbA1c) in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD) result in uncertainty about the best predictor of mortality among these pat...

Using machine learning to predict the risk of short-term and long-term death in acute kidney injury patients after commencing CRRT

The mortality rate and prognosis of short-term and long-term acute kidney injury (AKI) patients who undergo continuous renal replacement therapy (CRRT) are different. Setting up risk stratification tools for b...

Acute and chronic complication profiles among patients with chronic kidney disease in Alberta, Canada: a retrospective observational study

Chronic kidney disease (CKD) poses a substantial burden to individuals, caregivers, and healthcare systems. CKD is associated with higher risk for adverse events, including renal failure, cardiovascular diseas...

Bioelectrical impedance phase angle combined with physical function predicts pre-frailty in maintenance hemodialysis patients: a prospective study

The prevalence of pre-frailty is notably high among maintenance hemodialysis (MHD) patients. Pre-frailty, an early and reversible condition between non-frailty and frailty, can lead to adverse outcomes such as...

Guidewire entrapment in the Chiari network during the insertion of a hemodialysis catheter: a case report

The Chiari network, a remnant of fetal anatomy, consists of a mesh-like structure within the right atrium. With advancements in cardiac interventions, complications associated with the Chiari network have incr...

Prevalence and predictors of long-term progression of chronic kidney disease in people with HIV in Ghana from 2003–2018

HIV is associated with an increased risk of progression to chronic kidney disease (CKD), and this risk is higher in people of West African descent than many other ethnicities. Our study assessed the rates of e...

Experiences of family caregivers of individuals undergoing hemodialysis in Iran about caring during the COVID-19 pandemic: a qualitative study

The Coronavirus disease 2019 (COVID-19) pandemic has significantly affected various aspects of public health. The virus poses a particular threat to individuals with kidney failure undergoing hemodialysis and ...

The lived experiences of fatigue among patients receiving haemodialysis in Oman: a qualitative exploration

Fatigue among patients with end-stage kidney disease (ESKD) receiving haemodialysis imposes a substantial burden on patients’ quality of life and expected treatment outcomes. This study explores the perspectiv...

SGLT-2 inhibitors in chronic peritoneal dialysis patients: a follow-up study

Sodium-glucose transporter-2 inhibitors (SGLT-2i) are recommended for use in patients with type 2 diabetes comorbid atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease. Limited rep...

Renal cell carcinoma in a transplanted kidney: a retrospective evaluation

Kidney transplantation is the optimal treatment modality for patients with end-stage chronic kidney disease. The long-term mortality of kidney recipients is 48–82% lower than that of patients on the waiting li...

Is chronic kidney disease associated with osteoarthritis? The United States national health and nutrition examination survey 2011–2020

Chronic kidney disease (CKD) and osteoarthritis (OA) represent two frequently seen disorders among the general population, and they share several similar risk factors. The present work focused on assessing the...

Setting reasonable goals for kidney transplant referral among dialysis facilities

Determining whether a patient is eligible for kidney transplantation is complex. In this study, we estimate what proportion of patients with end-stage kidney disease (ESKD) might have been suitable candidates ...

Urinary N-acetyl-D-glucosaminidase can predict bleeding after a percutaneous kidney biopsy

A percutaneous kidney biopsy (PKB) allows nephrologists to make informed decisions for treating various kidney diseases; however, the risk of bleeding complications should be considered, given the vascularity ...

Routine cardiac biomarkers for the prediction of incident major adverse cardiac events in patients with glomerulonephritis: a real-world analysis using a global federated database

Glomerulonephritis (GN) is a leading cause of chronic kidney disease (CKD). Major adverse cardiovascular events (MACE) are prolific in CKD. The risk of MACE in GN cohorts is multifactorial. We investigated the...

Factors associated with patient activation among patients with diabetes on hemodialysis: a multicenter cross-sectional study from a developing country

Diabetes mellitus (DM) is a major public health concern with considerable morbidity and mortality. DM affects patients’ quality of life and can lead to multiple complications, including chronic kidney disease ...

Evaluation of serum levels of sestrin 2 and betatrophin in type 2 diabetic patients with diabetic nephropathy

Diabetic kidney disease (DKD) is one of the most serious microvascular complications of diabetes mellitus (DM) and the leading cause of chronic kidney disease (CKD) worldwide. Since obesity and type 2 DM (T2DM...

A single-center, open label, randomized, controlled study of hydroxychloroquine sulfate in the treatment of low risk PLA 2 R-associated membranous nephropathy

To evaluate the efficacy and safety of hydroxychloroquine sulfate (HCQ) in the treatment of low risk phospholipase A 2 receptor (PLA 2 R)-associated membranous nephropathy (MN).

Hypercalcaemia in gastrointestinal stromal tumour and sarcoidosis: a case report

Hypercalcaemia is a common manifestation of sarcoidosis but is sparingly described in gastrointestinal stromal tumours (GISTs). We describe a case of acute kidney injury and hypercalcemia resulting from simult...

Correction: Laboratory-based surveillance of chronic kidney disease in people with private health coverage in Brazil

The original article was published in BMC Nephrology 2024 25 :162

Increased level of TXNIP and nuclear translocation of TXN is associated with end stage renal disease and development of multiplex renal tumours

End-stage and acquired cystic renal disease (ESRD/ACRD) kidneys are characterized by inflammatory remodelling and multiplex renal cell carcinomas (RCC). Eosinophilic vacuolated tumour (EVT) occurs exclusively ...

Sodium selenite attenuates inflammatory response and oxidative stress injury by regulating the Nrf2/ARE pathway in contrast-induced acute kidney injury in rats

Contrast-induced acute kidney injury (CI-AKI) is an acute renal complication that occurs after intravascular contrast agent administration. Sodium selenite (SS) is an inorganic source of Se and has potent anti...

Diagnosis and treatment of secondary nephrotic syndrome with rash as the first symptom: a case report

Membranous nephropathy (MN) is a common type of nephrotic syndrome (NS) in adults, accounting for about 20–30% of cases. Although secondary to specific factors, the coexistence of MN and mantle cell lymphoma (...

Anti-C5 monoclonal antibody treatment showing pathological resolution of complement-mediated atypical hemolytic uremic syndrome: a case report

No reports have shown histological changes before and after anti-C5 monoclonal antibody treatment in patients with atypical hemolytic uremic syndrome (aHUS). Here, we report a rare case of complement-mediated ...

Hemodialysis patients have signs of a chronic thrombotic burden

Cardiovascular diseases are the dominant cause of morbidity in hemodialysis (HD) patients. Unless sufficient anticoagulation is used during HD, clotting may appear. The objective was to investigate if levels o...

Effect of rehabilitation on renal outcomes after acute kidney injury associated with cardiovascular disease: a retrospective analysis

Acute kidney injury (AKI) incidence is extremely high worldwide, and patients who develop AKI are at increased risk of developing chronic kidney disease (CKD), CKD progression, and end-stage kidney disease (ES...

Controversy between biopsy and risk in children with proteinuria: is there a paradigm war?

Proteinuria is a prevalent symptom of pediatric nephrology, while kidney biopsy remains the gold standard for kidney tissue analysis, and it is currently controversial. We report the rare case that the mutatio...

Randomized investigation of increased dialyzer membrane hydrophilicity on hemocompatibility and performance

Hemodialyzers should efficiently eliminate small and middle molecular uremic toxins and possess exceptional hemocompatibility to improve well-being of patients with end-stage kidney disease. However, performan...

The relationship between uric acid and bone mineral density in the intermediate stage of CKD 1–3

Some studies have suggested that uric acid has antioxidant properties that can prevent bone loss, but the relationship between uric acid and bone mineral density is controversial. The aim of this study was to ...

A safe and effective protocol for postdilution hemofiltration with regional citrate anticoagulation

Regional citrate anticoagulation (RCA) is recommended during continuous renal replacement therapy. Compared to systemic anticoagulation, RCA provides a longer filter lifespan with the risk of metabolic alkalos...

Case presentation: a severe case of cobalamin c deficiency presenting with nephrotic syndrome, malignant hypertension and hemolytic anemia

The etiology of nephrotic syndrome can vary, with underlying metabolic diseases being a potential factor. Cobalamin C (cblC) defect is an autosomal recessive inborn error of metabolism caused by mutations in the

Clinical practice guideline for the management of lipids in adults with diabetic kidney disease: abbreviated summary of the Joint Association of British Clinical Diabetologists and UK Kidney Association (ABCD-UKKA) Guideline 2024

The contribution of chronic kidney disease (CKD) towards the risk of developing cardiovascular disease (CVD) is magnified with co-existing type 1 or type 2 diabetes. Lipids are a modifiable risk factor and goo...

Nephrotic syndrome associated with solid malignancies: a systematic review

Nephrotic syndrome (NS) can occur as a paraneoplastic disorder in association with various types of carcinoma. However, paraneoplastic nephrotic syndrome (PNS) is often misdiagnosed as idiopathic nephrotic syn...

Assessing asymmetrical kidney function in living donors: a retrospective cohort study on CT metrics

Live donor kidney transplantation is the preferred kidney replacement therapy for eligible patients but requires thorough donor evaluation to minimise risks. Contemporary guidelines recommend split kidney func...

Prevalence and related factors of nephrolithiasis among medical staff in Qingdao, China: a retrospective cross-sectional study

Certain occupations may predispose individuals to urolithiasis, a multi-factorial disease. The study aimed to evaluate the prevalence and related factors of nephrolithiasis in medical staff in Qingdao, China.

The co-occurrence of sarcoidosis and anti-PLA2R-associated membranous nephropathy in a patient with underlying genetic susceptibility

Sarcoidosis is a multisystemic inflammatory disease, characterized by the presence of non-caseating, epithelioid granulomas. Glomerular disease in patients with sarcoidosis is rare and membranous nephropathy (...

Expression and significance of Fractalkine/CX3CL1 in MPO-AAV-associated glomerulonephritis rats

To investigate the expression and significance of Fractalkine (CX3CL1, FKN) in serum and renal tissue of myeloperoxidase and anti-neutrophil cytoplasmic antibody associated vasculitis (MPO-AAV) rats.

The Correction to this article has been published in BMC Nephrology 2024 25 :249

Spot urinary sodium in CKD patients: correlation with 24h-excretion and evaluation of commonly used prediction equations

Salt intake in CKD patients can affect cardiovascular risk and kidney disease progression. Twenty-four hour (24h) urine collections are often used to investigate salt metabolism but are cumbersome to perform. ...

A case report of autosomal recessive polycystic kidney disease with noncompaction of ventricular myocardium: coincidence or different manifestations of ciliopathy?

Autosomal recessive polycystic kidney disease (ARPKD) is a rare inherited cystic disease characterized by bilateral renal cyst formation and congenital liver fibrosis. Cardiovascular disorders such as noncompa...

The advanced lung cancer inflammation index is associated with mortality in peritoneal dialysis patients

There is still a very high morbidity and mortality rate for patients undergoing peritoneal dialysis (PD). The advanced lung cancer inflammation index (ALI) has been demonstrated to be associated with the progn...

The association between self-efficacy, perceived social support, and family resilience in patients undergoing hemodialysis: a cross-sectional study

Self-efficacy of patients on hemodialysis is considered a main component of the successful management of chronic kidney diseases. The self-efficacy of these patients may be influenced by many individual and so...

Changes in tubular biomarkers with dietary intervention and metformin in patients with autosomal dominant polycystic kidney disease: a post-hoc analysis of two clinical trials

Tubular biomarkers, which reflect tubular dysfunction or injury, are associated with incident chronic kidney disease and kidney function decline. Several tubular biomarkers have also been implicated in the pro...

Role of OPG/RANKL/RANK/TLR4 signaling pathway in sepsis-associated acute kidney injury

Sepsis-associated acute kidney injury (SA-AKI) has high mortality rates. The osteoprotegerin (OPG)/receptor activator of nuclear factor-κB ligand (RANKL)/receptor activator of nuclear factor-κB (RANK)/Toll-lik...

Diagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report

The concomitant occurrence of membranous nephropathy and anti-glomerular basement (anti-GBM) disease has been previously described but is extremely rare. However, delayed recognition or misdiagnosis leads to d...

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Citation Impact 2023 Journal Impact Factor: 2.2 5-year Journal Impact Factor: 2.6 Source Normalized Impact per Paper (SNIP): 0.907 SCImago Journal Rank (SJR): 0.697 Speed 2023 Submission to first editorial decision (median days): 22 Submission to acceptance (median days): 158 Usage 2023 Downloads: 3,053,628 Altmetric mentions: 3,742

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Research Themes and Trends in Ten Top-Ranked Nephrology Journals: A Text Mining Analysis

Affiliations.

1 Department of Health Services Administration, The University of Alabama at Birmingham, Birmingham, Alabama, USA, [email protected].
2 School of Engineering, Center for Integrated Systems, The University of Alabama at Birmingham, Birmingham, Alabama, USA, [email protected].
3 Division of Nephrology and Hypertension, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
4 Veterans Affairs Medical Center, Birmingham, Alabama, USA.
5 Department of Management Science and Information Systems, Spears School of Business, Oklahoma State University, Stillwater, Oklahoma, USA.
6 Center for Health Systems Innovation, Department of Management Science and Information Systems, Spears School of Business, Oklahoma State University, Stillwater, Oklahoma, USA.
7 Department of Health Services Administration, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
8 Acute, Chronic, and Continuing Care, School of Nursing, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
9 School of Finance, Operations Management and International Business, Collins College of Business, The University of Tulsa, Tulsa, Oklahoma, USA.
PMID: 31838480
DOI: 10.1159/000504871

Background: Nephrology research is expanding, and harnessing the much-needed information and data for the practice of evidence-based medicine is becoming more challenging. In this study, we used the natural language processing and text mining approach to mitigate some of these challenges.

Methods: We analyzed 17,412 abstracts from the top-10 nephrology journals over 10 years (2007-2017) by using latent semantic analysis and topic analysis.

Results: The analyses revealed 10 distinct topics (T) for nephrology research ranging from basic science studies, using animal modeling (T-1), to dialysis vascular access-related issues -(T-10). The trend analyses indicated that while the majority of topics stayed relatively stable, some of the research topics experienced increasing popularity over time such as studies focusing on mortality and survival (T-4) and Patient-related Outcomes and Perspectives of Clinicians (T-5). However, some research topics such as studies focusing on animal modeling (T-1), predictors of acute kidney injury, and dialysis access (T-10) exhibited a downward trend.

Conclusion: Stakeholders of nephrology research may use these trends further to develop priorities and enrich the research agenda for the future.

Keywords: Kidney; Nephrology; Text mining; Themes; Trends.

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In-depth topic review, novel research findings, brief report, transplantation: research article, review article, american journal of nephrology 2024, vol. 55, no. 4, association of diabetes with changes in blood pressure during hemodialysis: a secondary analysis of the frequent hemodialysis network daily trial, expanding the impact of sglt2 inhibitors in chronic kidney disease, deliverables from metabolomics in kidney disease: adenine, new insights, and implication for clinical decision-making, association of proton pump inhibitor use and immune checkpoint inhibitor-mediated acute kidney injury: a meta-analysis and a review of related outcomes, association of sevelamer initiation with gastrointestinal bleeding hospitalization in individuals requiring hemodialysis, safety profile and effectiveness of dapagliflozin in pediatric patients with chronic kidney disease, diagnostic yield of exome sequencing in early-onset hypertensive nephropathy in adults, trends, outcomes, and economic implications of peritoneal dialysis-associated peritonitis hospitalizations: a national cohort study, the risk factors and clinical outcomes in hepatitis b seropositive and seronegative renal transplant patients, the predictors and risk factors of 2-year rejection in renal transplant patients: a multicenter case-control study, proton pump inhibitors and kidney disease: fact or fiction, email alerts.

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For people with kidney failure, hemodialysis is a life saving treatment. On average, people can live for 5 to 10 years on dialysis, but many have lived 20 to 30 years. Hemodialysis also comes with some distressing symptoms like muscle cramps, itching, and fatigue. Doctor Jennifer Flythe and Precious McCowan, a dialysis patient and kidney advocate, are here to talk about a new study that aims to better monitor and help manage the symptoms of hemodialysis.

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Empowering the LGBTQIA+ community is important during Pride Month and beyond. Today we're speaking with Brian Sims, Living donor and former PA State Representative, and Josh Wilder, DPM, transplant recipient, podiatrist and former Survivor contestant, about how to empower the LGBTQIA+ community in kidney health and how to create an inclusive and affirming environment for all.

Unfiltered Story: Next steps after losing a transplant

Losing a kidney transplant can feel very overwhelming. Today we're here with Anthony Tuggle, a former NKF board member, to hear how he's coping with losing a transplant and learn what's next for him.

Coping with losing a transplant

Everyone loves to talk about kidney transplant success stories but rarely do we talk about what happens if a transplant fails. On today's episode Dori Muench, a post transplant social worker, and Sue George, a kidney warrior with experience losing a transplant, are here to discuss the impact of losing a kidney and how to cope.

Artificial Kidneys

When will the artificial kidney be ready for human use? Learn more about the progress of the artificial kidney and how it will affect someone's quality of life from expert Shuvo Roy, Ph.D.

What is a high KDPI kidney?

When a kidney from a deceased donor becomes available, it is scored on a system called the Kidney Donor Profile Index (KDPI). How accurate is it at predicting possible transplant survival? On this episode, we speak with experts to get the facts

Fad diets and kidney diets

It’s hard to keep up with all the new fad diets out there. Do you know which ones are right for you and your kidney health? On this episode, you will hear from experts on finding the diet that's right for you and how to stick to it.

Superfoods for people with kidney disease

You may have heard the buzzword superfoods but what are they and do they have special qualities? Board-certified renal dietitian, Jen Hernadez is here to break it down.

What do clinical end points and trials mean for CKD research?

Clinical trials exist to help prevent, screen for, diagnose, or treat diseases and other health problems. Without them, we would not have new treatments or other advances in health and medicine. But how are the clinical trial endpoints, or the preferred outcomes of these trials determined? Today, Anthony Gucciardo NKF’s Senior Vice President of Strategic Partnerships, Dr. Joseph Vassalotti, NKF’s Chief Medical Officer, and Kent Bressler, a Patient advocate and FSGS patient, discuss this and more.

Mindfulness meditation for kidney patients

You may have heard the term mindfulness before but what does it mean, what are the benefits, and how can you integrate mindfulness into your life? On today’s episode Gary Petingola a Social Worker certified to teach Mindfulness-Based Stress Reductionexplains all this and more.

Transplants for All

At the National Kidney Foundation, we believe that everyone who needs a kidney should get a kidney. To make this dream a reality, we’ve launched the Transplants for All Initiative. What is this initiative and how will it make a difference in the lives of people with kidney disease? In today’s episode special guests Morgan Reid, NKF’s Transplant Policy & Strategy Director and Haley Jenson, NKF’s Transplant Programs Director explain this and more.

BONUS: Sexuality and kidney disease

Sexual dysfunction is incredibly common in patients with kidney disease. In today's bonus episode, you'll learn about why it is so prevalent, the different treatment options, and how to improve communication around this important but often neglected aspect of health.

LGBTQ+ advocacy in healthcare

Over 50% of LGBTQIA-plus people have experienced some form of healthcare discrimination and over 25% of transgender people reported being denied care due to their transgender status. Not having proper health care or avoiding health care due to discrimination, can result in dire consequences, including an increased risk of health problems like kidney disease. What is this discrimination, and how can you advocate for yourself and LGBTQIA+ rights? In today’s episode Dr. Joshua Wilder, a podiatrist, and Representative Jeff Currey, two kidney transplant recipients and members of the LGBTQIA+ community, discuss this and more.

NKF Innovation Fund: developing new treatments for kidney patients

For far too long treatments for CKD haven’t changed. Launched in 2021, the NKF Innovation Fund works to accelerate funding, and development of therapies that kidney patients deserve. On this episode, you will hear from NKF CEO Kevin Longino interviews Kathleen St. Jean, Chief Commercial Officer of 34 Lives, one of the first recipients of a significant investment from NKF’s Innovation Fund to help further develop a new technology to rehabilitate donated kidneys for transplantation.

Living donors and mental health

Donating a kidney is one of the most selfless gifts one person can give to another. But what is that experience like for the donor before and after the transplant surgery? Today, we'll hear from Jessica Kolansky, a living kidney donor, and Alexandra Catalyst, a transplant coordinator, about the post transplant experience and what resources are available to donors after the surgery.

Laughter therapy for kidney patients

Is laughter really the best medicine? On today’s episode we’ll discuss an exciting new coping strategy for dialysis patients called guided group laughing therapy. What is it and how does it help? Dr. Paul Bennet who ran a study on the benefits of laughing therapy and Kimberly Super-Harrigan, a dialysis patient, are here to break it down.

BMI and weight management for kidney patients and living donors

Obesity is one of the major risk factors for developing kidney disease, which is measured through the body mass index or BMI. This measurement factors into the process for both living donors and transplant recipients. On today’s episode, you’ll learn how to measure your BMI and hear from both kidney patients on how managing their weight affected their kidney health.

Access to reproductive care for kidney patients

In 2022, the US Supreme Court overturned precedent established by Roe v Wade, eliminating the constitutional right to abortion. Family planning decisions can be difficult and complex for kidney patients. On today’s episode, we’ll discuss how this impacts kidney patients and disadvantaged patients with limited access to healthcare.

Game Changers: Treating CKD earlier

Did you know that 40% of chronic kidney disease progression may be preventable with earlier diagnosis and treatment? On this episode, you will hear the facts around treating CKD earlier from Dr. Joe Vassalotti, NKF’s Chief Medical Officer. You will also hear from Jane DeMeis on her journey with kidney disease.

Exercise and bone health: what CKD patients should know

Keeping your body and bones strong are important when you have kidney disease. Do you know what types of exercise are good for kidney patients? What about for transplant recipients or people on dialysis? In this episode, we sat down with experts to discuss the benefits and recommendations of managing an exercise routine.

Managing fluid intake as a CKD patient

It is important that certain individuals with CKD limit their fluid intake, but many don’t understand why or where to begin. On today’s episode, we sat down with experts to discuss fluid restriction, such as why it’s important, the negative effects of consuming too much, and ways to manage a fluid-restricted diet.

Treatment options for undocumented people with kidney disease

Undocumented people face increased barriers to accessing health coverage and care, including treatment for kidney disease. In this episode, our guest experts discuss what treatment options are currently available for undocumented people and what kind of advocacy efforts are being made to improve their access to health care.

Breaking Down New Medicare Coverage for Immunosuppressant Drugs

The Medicare coverage for immunosuppressive drugs for kidney transplant patients has recently been expanded. But what does this new benefit cover and who is eligible? in this podcast, Cynthia Nichols-Jackson, a registered nurse and a program coordinator for the National Kidney Foundation, and Troy Zimmerman, a special projects director for the National Kidney Foundation, discuss how this new policy will affect the future for kidney transplants.

Should You Follow A Special Diet After Transplant?

How potassium affects kidney patients

One of the jobs your kidneys is to manage your body’s levels of potassium, which keeps your heartbeat regular and your muscles working right. Many kidney patients need to watch what they eat to ensure that their potassium levels don’t become too high and cause dangerous health risks. On today’s episode, you’ll hear how to best manage your potassium levels to protect yourself.

How kidney patients should protect themselves from COVID-19 in 2022

While many people feel like the world is headed back to normal, many kidney patients can feel left behind. COVID-19 is still top of mind for those who are immunocompromised and we're here to offer resources and support. On today's episode, our guests will answer your questions about how COVID-19 affects transplant, dialysis, and early stage CKD patients.

What is basic science research and why is it important?

When we hear the word research, most of us think of innovative breakthrough treatments and technologies. But applied clinical research could not be possible without another type of research called basic science research in which scientists study the fundamental processes of the human body. In this episode, we’ll learn what basic science research is and how it applies to the area of kidneys and kidney disease.

Working with your clinician to make shared decisions for your care

Shared decision making can play a vital role in the treatment of kidney disease. When physicians involve patients in their care, they may be able to help slow progression and improve outcomes. In this episode, we discussed how patients and their physicians can achieve this and hear stories from patients who have been there.

How kidney disease affects your mental health

People with chronic conditions like kidney disease face mental health struggles such as depression or anxiety. In many kidney patients those challenges often go overlooked or undertreated. In this episode, we sat down with a mentor and mentee from NKF Peers to discuss their experiences and the importance of talking to someone who knows what you've been through.

Tips for finding a living donor

If you are in need of a kidney transplant, finding a living donor can sound scary and overwhelming. Where should you start and what’s the best way to share your story with the world? In this episode, you will hear from transplant recipients who once stood in your shoes.

Pig kidneys in humans? Xenotransplantation explained.

From the invention of the dialysis machine to the first successful kidney transplant, science has come a long way in extending life for kidney patients. Is transplantation between humans and animals the next step? In this episode, you will hear from a doctor behind the first successful transplant of a human receiving a pig kidney and where the science can take us from here.

Deciding to become a living donor

Pregnancy and kidney disease

Pregnancy can be an exciting time for most people, but what does it look like if you are a kidney patient? What does pregnancy look like if they have kidney disease, are on dialysis, or have received a transplant? In this episode, we’ll hear useful facts and tips from transplant nephrologist Dr. Mariana Markell, as well as personal stories from Cari Maxwell and Katie Reed, two mothers living with kidney disease.

What are SGLT2 Inhibitors and are they the right drug for you?

You might have heard about drugs called SGLT2 inhibitors used in treatment of kidney disease, but, just like many other kidney patients, you might not know if they’re right for you. On this episode, we explain how different SGLT2 inhibitors are from other kidney disease medications, discuss side effects, cost, and the ongoing research around this category of drugs.

How much sodium is safe for kidney patients?

Most patients on dialysis need to limit the amount of sodium in their diets. But how much sodium is safe and what are some ways to add flavor to your diet? On today‘s episode, our experts cover examples of high sodium foods, recommendations for low sodium substitutes, and how much sodium people with kidney disease should have as a part of a healthy diet.

What do changes to eGFR calculation mean for patients?

Tips for overcoming financial hardship for kidney patients

Many kidney disease patients often face financial hardships, such as having to leave a job or struggling to pay for medications. We sat down with physician and a postdoctoral research fellow Dr. Issac Acquah to talk about his recent research into the financial impact on people with chronic kidney disease.

How to become an advocate for kidney health

Over the past year, NKF advocates have won a number of policy campaigns both in Congress and state capitals across the country - but we're not done yet. In this episode, we discussed some recent wins and our upcoming challenges for the kidney advocate community with Jeff Currey, a Connecticut State Representative and kidney transplant recipient, and Armand Halter, an NKF patient advocate who helped lead NKF’s efforts to pass the Connecticut version of the Living Donor Protection Act.

A major worry for many people right now is the Delta variant, a highly contagious strain of COVID-19 which is making headlines across the United States. The FDA has just authorized a third dose of the COVID-19 vaccine so that immune compromised patients can better protecting themselves from the virus. What does this mean for CKD, dialysis, and transplant patients? We spoke with Dr. Joseph Vassalotti, NKF Chief Medical Officer, in a recent Facebook Live to share the facts about the Delta variant, COVID-19 booster shots, and other concerns facing kidney patients.

Coping with depression & anxiety during a global pandemic

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Potential Research Project Topics

Learn about the broad range of research subjects you can explore with the guidance of supportive, knowledgeable faculty.

Topics for research projects with specific investigators include:

Clinical informatics ( Sashank Kaushik ; Keith Krabill ; Mandip Panesar ; Richard Quigg ; Edwin Anand ; P. Ben Ham )
Epidemiology of acute kidney injury ( James Lohr )
Epidemiology of chronic kidney disease (CKD) ( Pradeep Arora )
Experimental models of renal disease ( Richard Quigg )
Experimental renal inflammation ( Jessy Alexander )
Functional genomics ( Richard Quigg )
Gut microbiota and renal diseases ( Rabi Yacoub )
Hypertension ( James Lohr ; Xiaoyan Wu )
Medication and toxin-induced acute kidney injury ( James Farry )
Megalin and kidney diseases ( Rabi Yacoub )
Monocytes in circulation and Macrophages in tissues ( Jessy Alexander )
Mouse models of sterile inflammation and autoimmunity ( Jessy Alexander )
Nephrin role in kidney development ( Rabi Yacoub )
Nephrin role in kidney disease ( Rabi Yacoub )
Neuropsychiatric lupus ( Jessy Alexander )
Nuances of complement and endothelial cells ( Jessy Alexander )
Pathobiology of the complement system ( Richard Quigg ; Jessy Alexander )
Uremic toxins and CVD/atherosclerosis ( Rabi Yacoub )

Recent Publications

Kareem S, Jacob A, Mathew J, Quigg RJ, Alexander JJ. (2023) Complement: Functions, location and implications. Immunology (Oct), 170(2): 180-192.
Bryniarski MA, Sandoval RM, Ruszaj DM, Fraser-McArthur J, Yee BM, Yacoub R, Chaves LD, Campos-Bilderback SB, Molitoris BA, Morris ME. (2023) Defining the Intravital Renal Disposition of Fluorescence-Quenched Exenatide. Molecular pharmaceutics (Feb), 20(2): 987-996. doi:10.1021/acs.molpharmaceut.2c00671

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GuidelineCentral Nephrology
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Nephrology Nursing Research Paper Topics

Nephrology nursing research paper topics are incredibly diverse and integral to the medical world. Nephrology nursing involves the care of patients with kidney disease and encompasses a variety of topics from the pathophysiology of kidney disease, to the management of kidney failure, requiring dialysis or transplantation. This field is constantly evolving with the advent of new technologies and treatments. As such, it is important for nursing students and professionals to be up-to-date with the latest research and trends in nephrology nursing. This article will provide a comprehensive list of research paper topics, a detailed discussion on the significance of nephrology nursing, an introduction to iResearchNet’s writing services, and a compelling call-to-action.

100 Nephrology Nursing Research Paper Topics

Nephrology nursing is a specialized area of nursing dedicated to individuals with kidney disease or kidney-related issues. It plays a vital role in managing the various stages of kidney diseases, from early detection and intervention to the management of advanced kidney failure. Research in this field is of paramount importance as it leads to the development of new treatments, management strategies, and preventive measures. The nephrology nursing research paper topics encompass a wide range of areas such as Acute Kidney Injury, Chronic Kidney Disease, Dialysis, Kidney Transplantation, and many more. Exploring these topics will not only enhance the knowledge of nursing students but also contribute to the betterment of patient care. List of 100 nephrology nursing research paper topics:

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Acute Kidney Injury:

The role of nursing in the management of acute kidney injury.
Early detection and prevention of acute kidney injury.
The impact of hydration status on the development of acute kidney injury.
Pharmacological interventions in acute kidney injury.
Acute kidney injury in critically ill patients.
The relationship between sepsis and acute kidney injury.
Biomarkers for early detection of acute kidney injury.
The role of renal replacement therapy in acute kidney injury.
Strategies to prevent contrast-induced acute kidney injury.
The impact of acute kidney injury on long-term kidney function.

Chronic Kidney Disease:

The role of nephrology nursing in the management of chronic kidney disease.
Strategies for early detection of chronic kidney disease.
The impact of dietary management on the progression of chronic kidney disease.
Exercise and its impact on chronic kidney disease progression.
The role of blood pressure control in the management of chronic kidney disease.
Management of anemia in chronic kidney disease.
The relationship between diabetes and chronic kidney disease.
Strategies to slow the progression of chronic kidney disease.
The impact of chronic kidney disease on cardiovascular health.
The role of patient education in the management of chronic kidney disease.
Best practices in hemodialysis care.
The role of peritoneal dialysis in kidney failure management.
Strategies to prevent infections in dialysis patients.
The impact of dialysis on quality of life.
Strategies to improve vascular access in hemodialysis patients.
The role of nursing in the management of dialysis-related complications.
Strategies to optimize fluid management in dialysis patients.
The impact of dialysis frequency on patient outcomes.
Nutritional management in dialysis patients.
The role of psychological support in the management of dialysis patients.

Kidney Transplantation:

Strategies to improve kidney transplantation outcomes.
The role of immunosuppressive therapy in kidney transplantation.
The impact of donor-recipient matching on kidney transplantation outcomes.
Strategies to prevent rejection in kidney transplant recipients.
The role of nursing in the post-transplant care of kidney transplant recipients.
Management of infections in kidney transplant recipients.
The impact of kidney transplantation on quality of life.
Strategies to prevent cardiovascular disease in kidney transplant recipients.
The role of patient education in the post-transplant period.
The impact of kidney transplantation on mental health.

Glomerular Diseases:

The role of nursing in the management of glomerular diseases.
Strategies for early detection of glomerular diseases.
The impact of immunosuppressive therapy on glomerular diseases.
Management of nephrotic syndrome.
Strategies to prevent progression of glomerular diseases.
The role of dietary management in glomerular diseases.
The impact of glomerular diseases on cardiovascular health.
Strategies to manage hypertension in patients with glomerular diseases.
The role of patient education in the management of glomerular diseases.
The impact of glomerular diseases on quality of life.

Tubulointerstitial Diseases:

The role of nursing in the management of tubulointerstitial diseases.
Strategies for early detection of tubulointerstitial diseases.
The impact of pharmacological interventions on tubulointerstitial diseases.
Management of acute interstitial nephritis.
Strategies to prevent progression of tubulointerstitial diseases.
The role of dietary management in tubulointerstitial diseases.
The impact of tubulointerstitial diseases on kidney function.
Strategies to manage electrolyte abnormalities in tubulointerstitial diseases.
The role of patient education in the management of tubulointerstitial diseases.
The impact of tubulointerstitial diseases on quality of life.

Genetic Disorders Affecting the Kidneys:

The role of nursing in the management of genetic disorders affecting the kidneys.
Strategies for early detection of genetic disorders affecting the kidneys.
The impact of genetic counseling on the management of genetic disorders affecting the kidneys.
Management of polycystic kidney disease.
Strategies to prevent progression of genetic disorders affecting the kidneys.
The role of dietary management in genetic disorders affecting the kidneys.
The impact of genetic disorders affecting the kidneys on cardiovascular health.
Strategies to manage hypertension in patients with genetic disorders affecting the kidneys.
The role of patient education in the management of genetic disorders affecting the kidneys.
The impact of genetic disorders affecting the kidneys on quality of life.

Hypertension and the Kidneys:

The role of nursing in the management of hypertension and the kidneys.
Strategies for early detection of hypertension-related kidney disease.
The impact of antihypertensive therapy on kidney function.
Management of hypertensive nephropathy.
Strategies to prevent progression of hypertension-related kidney disease.
The role of dietary management in hypertension and the kidneys.
The impact of hypertension on cardiovascular health.
Strategies to manage electrolyte abnormalities in hypertension-related kidney disease.
The role of patient education in the management of hypertension and the kidneys.
The impact of hypertension on quality of life.

Diabetic Nephropathy:

The role of nursing in the management of diabetic nephropathy.
Strategies for early detection of diabetic nephropathy.
The impact of glycemic control on the progression of diabetic nephropathy.
Management of diabetic kidney disease.
Strategies to prevent progression of diabetic nephropathy.
The role of dietary management in diabetic nephropathy.
The impact of diabetic nephropathy on cardiovascular health.
Strategies to manage hypertension in patients with diabetic nephropathy.
The role of patient education in the management of diabetic nephropathy.
The impact of diabetic nephropathy on quality of life.

Pediatric Nephrology:

The role of nursing in the management of pediatric nephrology.
Strategies for early detection of kidney disease in children.
The impact of congenital kidney anomalies on pediatric kidney function.
Management of pediatric acute kidney injury.
Strategies to prevent progression of kidney disease in children.
The role of dietary management in pediatric nephrology.
The impact of pediatric kidney disease on growth and development.
Strategies to manage hypertension in children with kidney disease.
The role of patient and parent education in pediatric nephrology.
The impact of pediatric kidney disease on quality of life.

The aforementioned list of nephrology nursing research paper topics covers a wide spectrum of issues related to kidney health and its management. Nephrology nursing is an essential and dynamic field, constantly adapting to the evolving medical landscape. It is crucial for students and professionals in the nursing field to delve into research topics that contribute to a better understanding of kidney diseases, improve patient outcomes, and enhance the quality of life for individuals with kidney-related health issues. This comprehensive list aims to facilitate the exploration of essential topics in nephrology nursing and contribute to the development of innovative strategies and interventions in kidney care.

The Range of Nephrology Nursing Research Paper Topics

Nephrology nursing is a critical and specialized area within the broader nursing discipline, focusing on the care of patients with kidney disease or kidney-related issues. It encompasses a wide range of activities, from early detection and management of kidney diseases to the care of patients undergoing dialysis or kidney transplantation. The significance of nephrology nursing cannot be understated, given the increasing prevalence of kidney diseases worldwide. This article will discuss the importance of nephrology nursing and various aspects of it, such as acute kidney injury, chronic kidney disease, and dialysis, which are all crucial nephrology nursing research paper topics.

Significance of Nephrology Nursing

The kidney is a vital organ responsible for various functions, including filtering waste products from the blood, regulating blood pressure, and maintaining electrolyte balance. Any dysfunction or disease affecting the kidney can have a significant impact on an individual’s overall health and quality of life. Nephrology nurses play a crucial role in the management of patients with kidney diseases, providing specialized care that can help manage symptoms, slow disease progression, and improve outcomes.

Nephrology nurses are trained to manage various aspects of kidney care, including administering medications, managing fluid and electrolyte balance, providing dialysis treatments, and educating patients and their families about kidney disease and its management. They also play a crucial role in the early detection of kidney diseases, as early intervention can often prevent or delay the progression of the disease.

Acute Kidney Injury

Acute kidney injury (AKI) is a sudden decline in kidney function that can occur due to various reasons, such as decreased blood flow to the kidneys, exposure to toxic substances, or an inflammatory process affecting the kidneys. AKI is a common condition associated with high morbidity and mortality rates, particularly among hospitalized patients. It is one of the essential nephrology nursing research paper topics as timely and appropriate management of AKI can significantly affect its outcome.

Nephrology nurses play a vital role in the management of patients with AKI. They are involved in the early detection of AKI by monitoring patients’ urine output, serum creatinine levels, and other relevant indicators. They also play a crucial role in the management of AKI by administering medications, managing fluid and electrolyte balance, and providing supportive care to patients.

Chronic Kidney Disease

Chronic kidney disease (CKD) is a long-term condition characterized by a gradual loss of kidney function over time. It is a common condition that affects millions of people worldwide and is associated with an increased risk of cardiovascular disease and other comorbidities. Managing CKD effectively is crucial to prevent its progression to end-stage kidney disease (ESKD), which requires dialysis or kidney transplantation.

Nephrology nurses play a vital role in the management of patients with CKD. They are involved in the early detection and monitoring of CKD by assessing patients’ kidney function and other relevant indicators regularly. They also play a crucial role in the management of CKD by administering medications, managing fluid and electrolyte balance, providing dietary counseling, and educating patients about the disease and its management.

Dialysis is a life-saving treatment that replaces the function of the kidneys in patients with ESKD. There are two main types of dialysis: hemodialysis and peritoneal dialysis. Hemodialysis involves filtering the blood through a machine, while peritoneal dialysis involves filtering the blood through the lining of the abdomen. Both types of dialysis require specialized care and management to ensure their effectiveness and minimize complications.

Nephrology nurses play a crucial role in the care of patients undergoing dialysis. They are involved in the preparation and management of the dialysis procedure, monitoring patients during dialysis, managing complications, and providing education and support to patients and their families. Nephrology nursing research paper topics related to dialysis include strategies to prevent infections, improve vascular access, optimize fluid management, and enhance patients’ quality of life.

In summary, nephrology nursing is a specialized area of nursing that plays a crucial role in the management of patients with kidney diseases. Nephrology nurses are involved in various aspects of kidney care, including the early detection and management of acute kidney injury and chronic kidney disease, and the care of patients undergoing dialysis. These are all essential nephrology nursing research paper topics that contribute to the improvement of patient outcomes and the advancement of the field. It is crucial for nursing students and professionals to explore these topics in-depth to develop a comprehensive understanding of nephrology nursing and contribute to the betterment of patient care.

iResearchNet’s Custom Writing Services

Are you a nursing student assigned to write a research paper on nephrology nursing? If so, you understand the importance of choosing a relevant and impactful topic. Nephrology nursing involves specialized care for patients with kidney diseases, from early detection and management to dialysis and transplantation. With the increasing prevalence of kidney diseases worldwide, it is crucial for nursing students and professionals to develop a comprehensive understanding of this field. At iResearchNet, we offer students the opportunity to order a custom nephrology nursing research paper on any topic. Our writing services are designed to help you produce a high-quality research paper that contributes to your academic success and the advancement of nephrology nursing.

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In conclusion, iResearchNet offers a comprehensive range of writing services to help you produce a high-quality nephrology nursing research paper. Our expert degree-holding writers, custom written works, in-depth research, and customized solutions are designed to meet your specific needs and contribute to your academic success. We offer flexible pricing, short deadlines, timely delivery, 24/7 support, absolute privacy, easy order tracking, and a money-back guarantee to ensure your satisfaction. We encourage you to utilize our services for your research paper needs and contribute to the advancement of nephrology nursing.

Secure Your Academic Success with iResearchNet!

As a nursing student, you are well aware of the critical role that nephrology nurses play in healthcare. They specialize in the care of patients with kidney diseases and disorders, a field that is both challenging and rewarding. A research paper in this area not only contributes to your academic success but also to the broader knowledge base of this essential nursing specialty. At iResearchNet, we are committed to supporting your academic journey by offering you the opportunity to order a custom nephrology nursing research paper on any topic of your choice.

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Your academic success is essential for your future career as a nurse, and submitting a high-quality research paper is a crucial part of that journey. At iResearchNet, we are dedicated to helping you achieve that success. With our customized solutions, expert writers, and commitment to quality, we provide a service that is unmatched. Don’t miss the opportunity to submit a research paper that stands out and reflects your dedication to excellence in nephrology nursing.

Take the first step towards securing your academic success. Order a custom nephrology nursing research paper from iResearchNet today and contribute to the advancement of this critical field of nursing. Your future patients and your professional development will thank you!

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SPECIALTY GRAND CHALLENGE article

Nephrology: a flourishing field with plentiful emerging topics.

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1 Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea
2 Basic-Clinical Convergence Research Institute, University of Ulsan, Ulsan, Republic of Korea
3 Disaster Preparedness and Response Committee, The Korean Society of Nephrology, Seoul, Republic of Korea
4 The Korean Society of Geriatric Nephrology, Seoul, Republic of Korea
5 Department of Internal Medicine, Min-Sheng General Hospital, Taoyuan City, Taiwan
6 Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
7 Graduate Institute of Toxicology, National Taiwan University College of Medicine, Taipei, Taiwan
8 Graduate Institute of Medical Education and Bioethics, National Taiwan University College of Medicine, Taipei, Taiwan

The word “nephrology”, the discipline that focuses on the biology and medical implications of studies surrounding the kidney, was first coined in 1960s based on the French word “néphrologie” and the Greek word “nephrós”. Our understandings of kidney biology evolve successively over time, from the elucidation of glomeruli, nephrons, and tubular physiology in the 19th century, to the understandings of kidney function measurement and kidney disease origins. 1 Despite the expansion of relevant knowledge base, therapeutic approaches capable of retarding kidney disease progression remain quite limited; only renin-angiontensin system inhibitors (RASi) demonstrated impressive outcome-improving efficacy in randomized controlled trials ( 1 , 2 ) two decades ago. Nowadays, encouraging advancements have been made in the nephrology field. We would like to briefly summarize these inspiring changes and provide personal accounts on important and emerging topics deserving particular attention in the future ( Figure 1 ).

Figure 1 . Emerging nephrology topics addressed in this opinion pieces.

Impactful clinical trials and outcome diversification

We witness a rapid deployment of novel compounds for combating kidney diseases since 2015. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) is among the first of its kind to exhibit renoprotective effects independent of its glycemic control capacity, as a class effect ( 3 , 4 ). Subsequently, glucagon-like peptide-1 receptor agonists (GLP-1RA) ( 5 ) and newer generations of non-steroidal mineralocorticoid receptor antagonists (nsMRAs) ( 6 ) are also found to exhibit benefits in reducing the risk of composite renal outcomes in patients with chronic kidney disease (CKD). Through reducing glomerular hyperfiltration and intraglomerular pressure, optimizing afferent/efferent arteriole hemodynamics, conferring glomerular and tubular cellular metabolic benefits, attenuating kidney tissue hypoxia, these compounds pave the way toward engineering and testing the next generation of renoprotective agents ( 7 ). Aside from drugs reducing adverse kidney outcomes, there are also drugs approved for targeting immunopathology capable of managing distinct glomerulonephritis recently. Targeted release formulation of budesonide and sparsentan, an endothelin and angiotensin 2 type 1 receptor antagonist, have been shown to achieve proteinuria reduction among patients with IgA nephropathy (IgAN) ( 8 ). Small molecular and RNA-based complement inhibitors are promising candidates for ameliorating IgAN disease severities ( 9 ). These results lend support to the flourishing nature of kidney disease treatment regimens. Moreover, we can expect rising numbers of clinical trials evaluating nephrology treatments in the upcoming era. Nephrologists should familiarize themselves with the work of trialists and how to interpret trial findings, so as to select appropriate therapies for their patients. In addition, patient reported outcome measures (PROMs) gain momentum as key outcomes nephrologists should not overlook. Patients with kidney diseases may have significantly lower chance of PROM improvement compared to those without ( 10 ). Interventions aiming to increase ones' survival and chances of kidney preservation should not come at the price of worsening their symptom burden. We, at the meantime, look forward to accumulating evidence supporting softer outcomes of novel kidney disease treatments in the foreseeable future.

Crosstalk between nephrology and other disciplines

Another important field would be the intersections between nephrology and other scientific disciplines. A well-established example is geriatric nephrology, addressing the fundamentals of senescence, how an organism ages, and how to care for older adults. Existing studies have pinpointed the rising prevalence and incidence of geriatric syndromes in patients with CKD, including frailty, sarcopenia, cognitive dysfunction, and disability. Among these degenerative phenotypes, frailty deserves particular attention, as its pathogenesis intertwines with that of CKD and its adverse influences extend far beyond survival ( 11 , 12 ). Identifying frailty followed by administering dedicated managements carries the potential of improving CKD patients' functional status and quality of life. Ameliorating uremic sarcopenia and malnutrition is also feasible through appropriate dietary counseling and exercise regimen prescription. Newer fields spawning from inter-disciplinary collaboration further include onconephrology, nephrocardiology, and nephro-palliative care ( 13 ). Nephrology as a discipline, builds on the development of physiology, pathology, and anatomy, but consolidates itself when maintenance dialysis is created and enters clinical practice. Thus, nephrology originates from the piecework of century-old human knowledge, grows incrementally and forms a firm scientific discipline, and now evolves further “into complexity” ( 14 ), partly assisted by the omic technology. Nephrology has now been transformed into a discipline that welcomes and actively encourages intimate collaborations with other scientific and medical fields.

Artificial intelligence (AI) applications in nephrology

AI significantly revolutionizes the modern medicine, as it provides an automated way to perform complex tasks with further enhancement enabled by self-learning from continuous data input. Nephrology researchers have been apt to incorporate AI into various aspects of this field. For instance, the Nephrotic Syndrome Study Network (NEPTUNE) group has already leveraged multi-layered analyses for kidney pathology classification and kidney disease progression risk prediction ( 15 ). The applications of AI have also been extended to evaluate and manage different diseases relevant to nephrology, such as gauging fluid balance among patients undergoing continuous renal replacement therapy (CRRT) ( 16 ), outcome prediction in peritoneal dialysis patients and kidney transplant recipients ( 17 , 18 ). The ability of AI to handle complex, multidimensional data makes it particularly suitable for nephrology, a discipline with diverse influential factors interacting with each other. Other topics of nephrology in which AI has been deployed involve the optimization and individualization of dialysis prescription; healthcare records, wearable devices, and physiologic signals produced during dialysis sessions are utilized to estimate the probability of untoward medical event ( 19 ). Image reading in CKD-mineral bone disorder has also been automatized and accelerated with the assistance of AI technology ( 20 ). These topics vividly illustrate the speed of AI uptake as a tool in the research and clinical field of nephrology.

Education in nephrology

Nephrology workforce has been dwindling in multiple countries around the world, and how to increase different background trainees' interest in this discipline warrants serious attention. The search for a better education context, modality or route, and content to enhance learning efficacy assumes importance. Trainees may feel ill-prepared for the contemporary nephrology practice, especially when they are at the forefront of facing technology enabled practice innovation ( 21 ). How to uphold the value of nephrology specialty for to-be nephrologists and junior ones remains under-explored ( 22 ). This will require individualization of education approach throughout the course of training and potentially be accomplished through careful mentoring. However, literature in this topic is scarce and urgently needed.

Patients with CKD also have increasingly complex care needs, but exciting treatments were previously in lack. We now have new and further upcoming novel therapeutic choices for retarding CKD progression, but we need to intensify the spread of relevant knowledge through continuous professional development. High quality nephrology care for exceptionally complex patients at different settings cannot be achieved without successful teams led by well-educated nephrologists. Professional education focusing on fostering the continuous growth of nephrologists should take into account important education theories and preferences, as shown in prior examples ( 23 ). Let's not forget that nephrologists are frequently in work-life imbalances, as they are overwhelmed by the mounting clinical workload. We expect for more emphasis on studies designing creative strategies related to all stages of nephrology education from trainees to established specialists, and also team members. This will help the community build a stronger backbone and be resilient to more challenges ahead.

Disaster medicine in nephrology

Recently we have seen more and more natural and manmade disasters complicating the appropriate provision of nephrology care to affected patients worldwide. However, the establishment of timely response procedures is rarely emphasized or achieved. Earthquakes in South Korea, Japan, and Taiwan highlight the need for disaster preparedness in nephrology, particularly for hemodialysis units. Prior experiences suggested that effective disaster responses require both logistics and training ( 24 ). These responses include establishing clear protocols, maintaining emergency supplies, training staff in emergency procedures, and educating patients on disaster preparedness. Moreover, a coordinated response system involving local dialysis units, regional centers, and governmental agencies is crucial ( 24 ). The need for an enhanced preparedness is particularly important for regions with a high population density and a large number of dialysis population, such as Taiwan and South Korea. The potential impact of disasters on the provision of nephrology care is concerning, making robust disaster response plans more critical. Through implementing comprehensive preparedness measures, nephrology providers in high-risk regions can significantly improve their capacity to maintain continuity of care for vulnerable dialysis patients during disasters, saving lives and minimizing complications under challenging circumstances. The experience with COVID-19 underscores the need for nephrology care providers to develop and maintain specific protocols for managing infectious disease outbreaks ( 25 ). Such protocols may include measures for patient isolation, staff protection, continuity of dialysis services and proper vaccination ( 26 ).

Nephrology is experiencing renaissance, with exciting developments across multiple aspects. The presence of impactful clinical trials testing novel therapies, increasing opportunities for interdisciplinary collaboration, and the integration of artificial intelligence exemplify this promising trend. These advancements reshape our existing approach of nephrology care and how we conduct nephrology researches. Simultaneously, this discipline faces challenges in education and workforce development, necessitating innovative strategies to attract and retain talented members. The emerging focus on disaster medicine in nephrology, particularly in regions with high dialysis populations such as South Korea and Taiwan, highlights the need for robust preparedness plans. It is therefore crucial for practitioners to stay abreast of these developments and contribute to the growth of future nephrology. We warmly welcome potential candidates to submit relevant and impactful manuscript to this section for consideration.

Author contributions

KY: Conceptualization, Formal analysis, Funding acquisition, Investigation, Validation, Writing – original draft, Writing – review & editing. C-TC: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing.

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The current study was financially sponsored by National Science and Technology Council, Taiwan (NSTC-112-2314-B-002-232-MY3) and a cooperative research fund from the Korean Society of Nephrology in 2023. The funders have no role in the conception, execution, and interpretation of this study.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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Keywords: artificial intelligence, chronic kidney disease, clinical trial, glucagon-like peptide-1 receptor agonist, IgA nephropathy, nephrology education, sodium-glucose cotransporter inhibitors, patient reported outcome measure

Citation: Yoo KD and Chao C-T (2024) Nephrology: a flourishing field with plentiful emerging topics. Front. Med. 11:1463540. doi: 10.3389/fmed.2024.1463540

Received: 12 July 2024; Accepted: 22 July 2024; Published: 02 August 2024.

Edited and reviewed by: Michel Goldman , Université Libre de Bruxelles, Belgium

Copyright © 2024 Yoo and Chao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Chia-Ter Chao, b88401084@ntu.edu.tw

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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Modernizing the Data Infrastructure for Clinical Research to Meet Evolving Demands for Evidence

1 Verily Life Sciences, South San Francisco, California
2 Center for Biostatistics & Qualitative Methodology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
3 Bakar Computational Health Sciences Institute, University of California, San Francisco
4 Center for Data-Driven Insights and Innovation, University of California Health, Oakland
5 Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
6 Departments of Surgery and Radiology and Institute for Health Policy Studies, University of California, San Francisco
7 Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia
8 Biogen, Boston, Massachusetts
9 Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
10 Yale University School of Medicine, New Haven, Connecticut
11 National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research Programme, London, United Kingdom
12 Intensive Care National Audit & Research Centre (ICNARC), London, United Kingdom
13 Highlander Health, Dallas, Texas

Importance The ways in which we access, acquire, and use data in clinical trials have evolved very little over time, resulting in a fragmented and inefficient system that limits the amount and quality of evidence that can be generated.

Observations Clinical trial design has advanced steadily over several decades. Yet the infrastructure for clinical trial data collection remains expensive and labor intensive and limits the amount of evidence that can be collected to inform whether and how interventions work for different patient populations. Meanwhile, there is increasing demand for evidence from randomized clinical trials to inform regulatory decisions, payment decisions, and clinical care. Although substantial public and industry investment in advancing electronic health record interoperability, data standardization, and the technology systems used for data capture have resulted in significant progress on various aspects of data generation, there is now a need to combine the results of these efforts and apply them more directly to the clinical trial data infrastructure.

Conclusions and Relevance We describe a vision for a modernized infrastructure that is centered around 2 related concepts. First, allowing the collection and rigorous evaluation of multiple data sources and types and, second, enabling the possibility to reuse health data for multiple purposes. We address the need for multidisciplinary collaboration and suggest ways to measure progress toward this goal.

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Perspective
Published: 25 June 2020

Ethical challenges in nephrology: a call for action

Dominique E. Martin ORCID: orcid.org/0000-0001-9363-0770 1 ,
David C. H. Harris 2 ,
Vivekanand Jha 3 , 4 , 5 ,
Luca Segantini ORCID: orcid.org/0000-0003-4949-8623 6 , 7 ,
Richard A. Demme 8 ,
Thu H. Le 9 ,
Laura McCann 10 ,
Jeff M. Sands ORCID: orcid.org/0000-0001-9822-0607 11 ,
Gerard Vong ORCID: orcid.org/0000-0002-1315-1858 12 ,
Paul Root Wolpe 12 ,
Monica Fontana 13 ,
Gerard M. London 14 ,
Bert Vanderhaegen 15 ,
Raymond Vanholder ORCID: orcid.org/0000-0003-2633-1636 16 &

ASN-ERA-EDTA-ISN Joint Working Group on Ethical Issues in Nephrology

Nature Reviews Nephrology volume 16 , pages 603–613 ( 2020 ) Cite this article

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The American Society of Nephrology, the European Renal Association–European Dialysis and Transplant Association and the International Society of Nephrology Joint Working Group on Ethical Issues in Nephrology have identified ten broad areas of ethical concern as priority challenges that require collaborative action. Here, we describe these challenges — equity in access to kidney failure care, avoiding futile dialysis, reducing dialysis costs, shared decision-making in kidney failure care, living donor risk evaluation and decision-making, priority setting in kidney disease prevention and care, the ethical implications of genetic kidney diseases, responsible advocacy for kidney health and management of conflicts of interest — with the aim of highlighting the need for ethical analysis of specific issues, as well as for the development of tools and training to support clinicians who treat patients with kidney disease in practising ethically and contributing to ethical policy-making.

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Patient-centred clinical trial design

Ethical considerations for genetic research in low-income countries: perceptions of informed consent, data sharing, and expectations in Nicaragua

Inequities in kidney health and kidney care

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Martin, D.E., Harris, D.C.H., Jha, V. et al. Ethical challenges in nephrology: a call for action. Nat Rev Nephrol 16 , 603–613 (2020). https://doi.org/10.1038/s41581-020-0295-4

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Keywords: Nephrology, chronic kidney diseases, new advances, kideny function, renal diseases . Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements.Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer ...
Research Areas < Nephrology
Research Areas. The research activities of our faculty cover a broad range of topics in renal physiology and nephrology from laboratory bench to patient oriented investigation. Current areas of research focus include studies of the mechanisms of acute kidney injury and repair, molecular genetics of polycystic kidney disease and other cilia ...
What's new in nephrology and hypertension
PEDIATRIC NEPHROLOGY. Association between obesity in adolescence and development of chronic kidney disease (April 2024) Observational studies have suggested that adolescents with obesity are at increased risk for impaired kidney function. In a new study of 630,000 adolescents in Israel, high body mass index (BMI) in late adolescence was ...
Kidney Disease and Antinephrin Antibodies
This editorial describes the science behind detecting and treating autoimmunity in kidney disease.
Nephrology Topics
A collection of Nephrology information, resources and CME activities on Medscape. ... Nephrology Topics. ... About You Professional Information Newsletters & Alerts Advertise Market Research. App ...
A new era in the science and care of kidney diseases
Notable progress in basic, translational and clinical nephrology research has been made over the past five decades. Nonetheless, many challenges remain, including obstacles to the early detection ...
Research Topics, News & Clinical Resources
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Volume 55 Issue 4
In-Depth Topic Review. Novel Research Findings. Brief Report. Transplantation: Research Article. Review Article. Issue Navigation. American Journal of Nephrology 2024, Vol. 55, No. 4. Patient-Oriented, Translational Research: Research Article Association of Diabetes with Changes in Blood Pressure during Hemodialysis: A Secondary Analysis of the ...
Hot Topics in Kidney Health
Hot Topics in Kidney Health . Hot Topics in Kidney Health. Join us as we highlight the latest in kidney research, dispel myths, bring you up-to-date news in kidney care, and answer questions from patients to help them live well with kidney disease or a transplant. ... NKF and the American Society of Nephrology announced that our joint taskforce ...
Potential Research Project Topics
Nephrology > Research and Scholarship > Potential Research Project Topics; Nephrology. Message from the Program Director; Curriculum; Clinical Training Sites; ... Potential Research Project Topics; Site Index. Department of Medicine . 7/3/24 About Us; 5/21/19 Education and Training; 6/29/21 Fellowship Programs;
Case Reports in Frontiers in Nephrology
Frontiers in Nephrology is proud to present our inaugural Case Reports series.This Research Topic highlights high-quality case reports published in the journal, reporting on all traditional aspects of nephrology. It also covers complementary facets that are critical for a clear understanding of the current field and upcoming challenges.Case reports aim to highlight unique cases of patients ...
Guides: Nephrology and Hypertension: Clinical Resources
Clinical Handbook of Nephrology by Robert S. Brown, 2024 Nephrology, the subspecialty of internal medicine which covers the diagnosis and treatment of kidney diseases, hypertension, electrolyte and acid-base disorders, dialysis, and kidney transplantation, is often viewed as very difficult to master. Moreover, many major nephrology textbooks offer more information than students, residents ...
Nephrology Nursing Research Paper Topics
100 Nephrology Nursing Research Paper Topics. Nephrology nursing is a specialized area of nursing dedicated to individuals with kidney disease or kidney-related issues. It plays a vital role in managing the various stages of kidney diseases, from early detection and intervention to the management of advanced kidney failure.
Study shows donor kidneys with toxoplasma do not ...
The research was published in Transplant International. "Organs from donors who were positive for toxoplasma did just as well as organs from those who were negative, both for survival of the patients and survival of the kidneys," said Lavjay Butani, chief of pediatric nephrology.
Anti-nephrin autoantibodies: a paradigm shift in ...
A new study demonstrates that anti-nephrin autoantibodies are not merely markers but also actively contribute to the pathogenesis of minimal change disease and primary focal segmental ...
Nephrology nursing publications: Topics and research methods
Abstract. Four peer-reviewed nephrology nursing society journal publications from 2010 to 2015 were analysed. Journal articles (n=638) were categorised into type, treatment cohort, specific topic ...
Nephrology: a flourishing field with plentiful emerging topics
These topics vividly illustrate the speed of AI uptake as a tool in the research and clinical field of nephrology. Education in nephrology. Nephrology workforce has been dwindling in multiple countries around the world, and how to increase different background trainees' interest in this discipline warrants serious attention.
Modernizing the Data Infrastructure for Clinical Research to Meet
Importance The ways in which we access, acquire, and use data in clinical trials have evolved very little over time, resulting in a fragmented and inefficient system that limits the amount and quality of evidence that can be generated.. Observations Clinical trial design has advanced steadily over several decades. Yet the infrastructure for clinical trial data collection remains expensive and ...
Ethical challenges in nephrology: a call for action
Despite extensive research into factors that influence equity of access to nephrology care 1,2,3,4,5,6, and the publication of several studies on a wide range of ethical issues that nephrologists ...
How does an effective cancer therapy damage the heart?
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a protein receptor on T immune cells that prevents the cells from killing other cells, such as cancer cells. Blocking CTLA-4 with a specific antibody is an effective treatment for some cancers, but it can damage the heart. New research published in The FASEB Journal reveals the mechanisms involved in this side effect—a finding that could be used ...