how to find research articles

• Corrections

Search Help

Get the most out of Google Scholar with some helpful tips on searches, email alerts, citation export, and more.

Finding recent papers

Your search results are normally sorted by relevance, not by date. To find newer articles, try the following options in the left sidebar:

• click "Since Year" to show only recently published papers, sorted by relevance;
• click "Sort by date" to show just the new additions, sorted by date;
• click the envelope icon to have new results periodically delivered by email.

Locating the full text of an article

Abstracts are freely available for most of the articles. Alas, reading the entire article may require a subscription. Here're a few things to try:

• click a library link, e.g., "FindIt@Harvard", to the right of the search result;
• click a link labeled [PDF] to the right of the search result;
• click "All versions" under the search result and check out the alternative sources;
• click "Related articles" or "Cited by" under the search result to explore similar articles.

If you're affiliated with a university, but don't see links such as "FindIt@Harvard", please check with your local library about the best way to access their online subscriptions. You may need to do search from a computer on campus, or to configure your browser to use a library proxy.

Getting better answers

If you're new to the subject, it may be helpful to pick up the terminology from secondary sources. E.g., a Wikipedia article for "overweight" might suggest a Scholar search for "pediatric hyperalimentation".

If the search results are too specific for your needs, check out what they're citing in their "References" sections. Referenced works are often more general in nature.

Similarly, if the search results are too basic for you, click "Cited by" to see newer papers that referenced them. These newer papers will often be more specific.

Explore! There's rarely a single answer to a research question. Click "Related articles" or "Cited by" to see closely related work, or search for author's name and see what else they have written.

Searching Google Scholar

Use the "author:" operator, e.g., author:"d knuth" or author:"donald e knuth".

Put the paper's title in quotations: "A History of the China Sea".

You'll often get better results if you search only recent articles, but still sort them by relevance, not by date. E.g., click "Since 2018" in the left sidebar of the search results page.

To see the absolutely newest articles first, click "Sort by date" in the sidebar. If you use this feature a lot, you may also find it useful to setup email alerts to have new results automatically sent to you.

Note: On smaller screens that don't show the sidebar, these options are available in the dropdown menu labelled "Year" right below the search button.

Select the "Case law" option on the homepage or in the side drawer on the search results page.

It finds documents similar to the given search result.

It's in the side drawer. The advanced search window lets you search in the author, title, and publication fields, as well as limit your search results by date.

Select the "Case law" option and do a keyword search over all jurisdictions. Then, click the "Select courts" link in the left sidebar on the search results page.

Tip: To quickly search a frequently used selection of courts, bookmark a search results page with the desired selection.

Access to articles

For each Scholar search result, we try to find a version of the article that you can read. These access links are labelled [PDF] or [HTML] and appear to the right of the search result. For example:

A paper that you need to read

Access links cover a wide variety of ways in which articles may be available to you - articles that your library subscribes to, open access articles, free-to-read articles from publishers, preprints, articles in repositories, etc.

When you are on a campus network, access links automatically include your library subscriptions and direct you to subscribed versions of articles. On-campus access links cover subscriptions from primary publishers as well as aggregators.

Off-campus access

Off-campus access links let you take your library subscriptions with you when you are at home or traveling. You can read subscribed articles when you are off-campus just as easily as when you are on-campus. Off-campus access links work by recording your subscriptions when you visit Scholar while on-campus, and looking up the recorded subscriptions later when you are off-campus.

We use the recorded subscriptions to provide you with the same subscribed access links as you see on campus. We also indicate your subscription access to participating publishers so that they can allow you to read the full-text of these articles without logging in or using a proxy. The recorded subscription information expires after 30 days and is automatically deleted.

In addition to Google Scholar search results, off-campus access links can also appear on articles from publishers participating in the off-campus subscription access program. Look for links labeled [PDF] or [HTML] on the right hand side of article pages.

Anne Author , John Doe , Jane Smith , Someone Else

In this fascinating paper, we investigate various topics that would be of interest to you. We also describe new methods relevant to your project, and attempt to address several questions which you would also like to know the answer to. Lastly, we analyze …

You can disable off-campus access links on the Scholar settings page . Disabling off-campus access links will turn off recording of your library subscriptions. It will also turn off indicating subscription access to participating publishers. Once off-campus access links are disabled, you may need to identify and configure an alternate mechanism (e.g., an institutional proxy or VPN) to access your library subscriptions while off-campus.

Email Alerts

Do a search for the topic of interest, e.g., "M Theory"; click the envelope icon in the sidebar of the search results page; enter your email address, and click "Create alert". We'll then periodically email you newly published papers that match your search criteria.

No, you can enter any email address of your choice. If the email address isn't a Google account or doesn't match your Google account, then we'll email you a verification link, which you'll need to click to start receiving alerts.

This works best if you create a public profile , which is free and quick to do. Once you get to the homepage with your photo, click "Follow" next to your name, select "New citations to my articles", and click "Done". We will then email you when we find new articles that cite yours.

Search for the title of your paper, e.g., "Anti de Sitter space and holography"; click on the "Cited by" link at the bottom of the search result; and then click on the envelope icon in the left sidebar of the search results page.

First, do a search for your colleague's name, and see if they have a Scholar profile. If they do, click on it, click the "Follow" button next to their name, select "New articles by this author", and click "Done".

If they don't have a profile, do a search by author, e.g., [author:s-hawking], and click on the mighty envelope in the left sidebar of the search results page. If you find that several different people share the same name, you may need to add co-author names or topical keywords to limit results to the author you wish to follow.

We send the alerts right after we add new papers to Google Scholar. This usually happens several times a week, except that our search robots meticulously observe holidays.

There's a link to cancel the alert at the bottom of every notification email.

If you created alerts using a Google account, you can manage them all here . If you're not using a Google account, you'll need to unsubscribe from the individual alerts and subscribe to the new ones.

Google Scholar library

Google Scholar library is your personal collection of articles. You can save articles right off the search page, organize them by adding labels, and use the power of Scholar search to quickly find just the one you want - at any time and from anywhere. You decide what goes into your library, and we’ll keep the links up to date.

You get all the goodies that come with Scholar search results - links to PDF and to your university's subscriptions, formatted citations, citing articles, and more!

Library help

Find the article you want to add in Google Scholar and click the “Save” button under the search result.

Click “My library” at the top of the page or in the side drawer to view all articles in your library. To search the full text of these articles, enter your query as usual in the search box.

Find the article you want to remove, and then click the “Delete” button under it.

• To add a label to an article, find the article in your library, click the “Label” button under it, select the label you want to apply, and click “Done”.
• To view all the articles with a specific label, click the label name in the left sidebar of your library page.
• To remove a label from an article, click the “Label” button under it, deselect the label you want to remove, and click “Done”.
• To add, edit, or delete labels, click “Manage labels” in the left column of your library page.

Only you can see the articles in your library. If you create a Scholar profile and make it public, then the articles in your public profile (and only those articles) will be visible to everyone.

Your profile contains all the articles you have written yourself. It’s a way to present your work to others, as well as to keep track of citations to it. Your library is a way to organize the articles that you’d like to read or cite, not necessarily the ones you’ve written.

Citation Export

Click the "Cite" button under the search result and then select your bibliography manager at the bottom of the popup. We currently support BibTeX, EndNote, RefMan, and RefWorks.

Err, no, please respect our robots.txt when you access Google Scholar using automated software. As the wearers of crawler's shoes and webmaster's hat, we cannot recommend adherence to web standards highly enough.

Sorry, we're unable to provide bulk access. You'll need to make an arrangement directly with the source of the data you're interested in. Keep in mind that a lot of the records in Google Scholar come from commercial subscription services.

Sorry, we can only show up to 1,000 results for any particular search query. Try a different query to get more results.

Content Coverage

Google Scholar includes journal and conference papers, theses and dissertations, academic books, pre-prints, abstracts, technical reports and other scholarly literature from all broad areas of research. You'll find works from a wide variety of academic publishers, professional societies and university repositories, as well as scholarly articles available anywhere across the web. Google Scholar also includes court opinions and patents.

We index research articles and abstracts from most major academic publishers and repositories worldwide, including both free and subscription sources. To check current coverage of a specific source in Google Scholar, search for a sample of their article titles in quotes.

While we try to be comprehensive, it isn't possible to guarantee uninterrupted coverage of any particular source. We index articles from sources all over the web and link to these websites in our search results. If one of these websites becomes unavailable to our search robots or to a large number of web users, we have to remove it from Google Scholar until it becomes available again.

Our meticulous search robots generally try to index every paper from every website they visit, including most major sources and also many lesser known ones.

That said, Google Scholar is primarily a search of academic papers. Shorter articles, such as book reviews, news sections, editorials, announcements and letters, may or may not be included. Untitled documents and documents without authors are usually not included. Website URLs that aren't available to our search robots or to the majority of web users are, obviously, not included either. Nor do we include websites that require you to sign up for an account, install a browser plugin, watch four colorful ads, and turn around three times and say coo-coo before you can read the listing of titles scanned at 10 DPI... You get the idea, we cover academic papers from sensible websites.

That's usually because we index many of these papers from other websites, such as the websites of their primary publishers. The "site:" operator currently only searches the primary version of each paper.

It could also be that the papers are located on examplejournals.gov, not on example.gov. Please make sure you're searching for the "right" website.

That said, the best way to check coverage of a specific source is to search for a sample of their papers using the title of the paper.

Ahem, we index papers, not journals. You should also ask about our coverage of universities, research groups, proteins, seminal breakthroughs, and other dimensions that are of interest to users. All such questions are best answered by searching for a statistical sample of papers that has the property of interest - journal, author, protein, etc. Many coverage comparisons are available if you search for [allintitle:"google scholar"], but some of them are more statistically valid than others.

Currently, Google Scholar allows you to search and read published opinions of US state appellate and supreme court cases since 1950, US federal district, appellate, tax and bankruptcy courts since 1923 and US Supreme Court cases since 1791. In addition, it includes citations for cases cited by indexed opinions or journal articles which allows you to find influential cases (usually older or international) which are not yet online or publicly available.

Legal opinions in Google Scholar are provided for informational purposes only and should not be relied on as a substitute for legal advice from a licensed lawyer. Google does not warrant that the information is complete or accurate.

We normally add new papers several times a week. However, updates to existing records take 6-9 months to a year or longer, because in order to update our records, we need to first recrawl them from the source website. For many larger websites, the speed at which we can update their records is limited by the crawl rate that they allow.

Inclusion and Corrections

We apologize, and we assure you the error was unintentional. Automated extraction of information from articles in diverse fields can be tricky, so an error sometimes sneaks through.

Please write to the owner of the website where the erroneous search result is coming from, and encourage them to provide correct bibliographic data to us, as described in the technical guidelines . Once the data is corrected on their website, it usually takes 6-9 months to a year or longer for it to be updated in Google Scholar. We appreciate your help and your patience.

If you can't find your papers when you search for them by title and by author, please refer your publisher to our technical guidelines .

You can also deposit your papers into your institutional repository or put their PDF versions on your personal website, but please follow your publisher's requirements when you do so. See our technical guidelines for more details on the inclusion process.

We normally add new papers several times a week; however, it might take us some time to crawl larger websites, and corrections to already included papers can take 6-9 months to a year or longer.

Google Scholar generally reflects the state of the web as it is currently visible to our search robots and to the majority of users. When you're searching for relevant papers to read, you wouldn't want it any other way!

If your citation counts have gone down, chances are that either your paper or papers that cite it have either disappeared from the web entirely, or have become unavailable to our search robots, or, perhaps, have been reformatted in a way that made it difficult for our automated software to identify their bibliographic data and references. If you wish to correct this, you'll need to identify the specific documents with indexing problems and ask your publisher to fix them. Please refer to the technical guidelines .

Please do let us know . Please include the URL for the opinion, the corrected information and a source where we can verify the correction.

We're only able to make corrections to court opinions that are hosted on our own website. For corrections to academic papers, books, dissertations and other third-party material, click on the search result in question and contact the owner of the website where the document came from. For corrections to books from Google Book Search, click on the book's title and locate the link to provide feedback at the bottom of the book's page.

General Questions

These are articles which other scholarly articles have referred to, but which we haven't found online. To exclude them from your search results, uncheck the "include citations" box on the left sidebar.

First, click on links labeled [PDF] or [HTML] to the right of the search result's title. Also, check out the "All versions" link at the bottom of the search result.

Second, if you're affiliated with a university, using a computer on campus will often let you access your library's online subscriptions. Look for links labeled with your library's name to the right of the search result's title. Also, see if there's a link to the full text on the publisher's page with the abstract.

Keep in mind that final published versions are often only available to subscribers, and that some articles are not available online at all. Good luck!

Technically, your web browser remembers your settings in a "cookie" on your computer's disk, and sends this cookie to our website along with every search. Check that your browser isn't configured to discard our cookies. Also, check if disabling various proxies or overly helpful privacy settings does the trick. Either way, your settings are stored on your computer, not on our servers, so a long hard look at your browser's preferences or internet options should help cure the machine's forgetfulness.

Not even close. That phrase is our acknowledgement that much of scholarly research involves building on what others have already discovered. It's taken from Sir Isaac Newton's famous quote, "If I have seen further, it is by standing on the shoulders of giants."

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• 07 July 2022

How to find, read and organize papers

• Maya Gosztyla 0

Maya Gosztyla is a PhD student in biomedical sciences at the University of California, San Diego.

You can also search for this author in PubMed   Google Scholar

“I’ll read that later,” I told myself as I added yet another paper to my 100+ open browser tabs.

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Finding Scholarly Articles: Home

What's a Scholarly Article?

Your professor has specified that you are to use scholarly (or primary research or peer-reviewed or refereed or academic) articles only in your paper. What does that mean?

Scholarly or primary research articles are peer-reviewed , which means that they have gone through the process of being read by reviewers or referees  before being accepted for publication. When a scholar submits an article to a scholarly journal, the manuscript is sent to experts in that field to read and decide if the research is valid and the article should be published. Typically the reviewers indicate to the journal editors whether they think the article should be accepted, sent back for revisions, or rejected.

To decide whether an article is a primary research article, look for the following:

• The author’s (or authors') credentials and academic affiliation(s) should be given;
• There should be an abstract summarizing the research;
• The methods and materials used should be given, often in a separate section;
• There are citations within the text or footnotes referencing sources used;
• Results of the research are given;
• There should be discussion   and  conclusion ;
• With a bibliography or list of references at the end.

Caution: even though a journal may be peer-reviewed, not all the items in it will be. For instance, there might be editorials, book reviews, news reports, etc. Check for the parts of the article to be sure.   

You can limit your search results to primary research, peer-reviewed or refereed articles in many databases. To search for scholarly articles in  HOLLIS , type your keywords in the box at the top, and select  Catalog&Articles  from the choices that appear next.   On the search results screen, look for the  Show Only section on the right and click on  Peer-reviewed articles . (Make sure to  login in with your HarvardKey to get full-text of the articles that Harvard has purchased.)

Many of the databases that Harvard offers have similar features to limit to peer-reviewed or scholarly articles.  For example in Academic Search Premier , click on the box for Scholarly (Peer Reviewed) Journals  on the search screen.

Review articles are another great way to find scholarly primary research articles.   Review articles are not considered "primary research", but they pull together primary research articles on a topic, summarize and analyze them.  In Google Scholar , click on Review Articles  at the left of the search results screen. Ask your professor whether review articles can be cited for an assignment.

A note about Google searching.  A regular Google search turns up a broad variety of results, which can include scholarly articles but Google results also contain commercial and popular sources which may be misleading, outdated, etc.  Use Google Scholar  through the Harvard Library instead.

About Wikipedia .  W ikipedia is not considered scholarly, and should not be cited, but it frequently includes references to scholarly articles. Before using those references for an assignment, double check by finding them in Hollis or a more specific subject  database .

Still not sure about a source? Consult the course syllabus for guidance, contact your professor or teaching fellow, or use the Ask A Librarian service.

• Last Updated: Oct 3, 2023 3:37 PM
• URL: https://guides.library.harvard.edu/FindingScholarlyArticles

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Reference management. Clean and simple.

How to efficiently search online databases for academic research

How to access academic databases

How to search academic databases, 1. use the campus network to access research databases, 2. find databases that are specifically related to your topic, 3. set up the search parameters within a database to be as narrow as possible, 4. ask a librarian for help, 5. slowly expand your search to get additional results, 6. use the pro features of the database, 7. try a more general database, if needed, 8. keep track of seminal works, frequently asked questions about searching online databases, related articles.

University libraries provide access to plenty of online academic databases that can yield good results when you use the right strategies. They are among the best sources to turn to when you need to find articles from scholarly journals, books, and other periodicals.

Searching an online research database is much like searching the internet, but the hits returned will be scholarly articles and other academic sources, depending on the subject. In this guide, we highlight 8 tips for searching academic databases.

• Use college and university library networks.
• Search subject-specific databases.
• Set up search parameters.
• Ask a librarian for help.
• Narrow or broaden your search, as needed.
• Use the pro features, where applicable.
• Try a more general database.
• Keep track of seminal works.

Tip: The best practice is to use the links provided on your library's website to access academic databases.

Most academic databases cannot be accessed for free. As authoritative resources, these multi-disciplinary databases are comprehensive collections of the current literature on a broad range of topics. Because they have a huge range of publications, public access is sometimes restricted.

College and university libraries pay for subscriptions to popular academic databases. As a student, staff, or faculty member, you can access these resources from home thanks to proxy connections.

➡️ Check out our list of EZProxy connections to see if your institution provides such a service.

Tip: Searching the right databases is key to finding the right academic journals.

Around 2.5 million articles are published EACH year. As a result, it's important to search the right database for the reference you need. Comprehensive databases often contain subject-specific resources and filters and these will help you narrow down your search results. Otherwise, you will have to screen too many unrelated papers that won't give you the reference you want.

Ask a librarian or check your library's A-Z resource list to find out which databases you can access. If you do not know where to start, you can check out the three biggest academic database providers:

➡️ Take a look at our compilations of research databases for computer science or healthcare .

Unlike in a Google search, typing in full sentences will not bring you satisfactory results. Some strategies for narrowing search parameters include:

• Narrowing your search terms in order to get the most pertinent information from the scholarly resources you are reviewing
• Narrowing results by filters like specific date range or source type
• Using more specific keywords

If your university library has a subject specialist in your field, you may want to contact them for guidance on keywords and other subject- and database-specific search strategies. Consider asking a librarian to meet you for a research consultation.

A specific search might not return as many results. This can be good because these results will most likely be current and applicable. If you do not get enough results, however, slowly expand the:

• type of journal

From there, you'll be able to find a wider variety of related technical reports, books, academic journals, and other potential results that you can use for your research.

Academic search engines and databases are getting smart! In the age of big data and text mining, many databases crunch millions of scientific papers to extract connections between them. Watch out for things like:

• related relevant articles
• similar academic resources
• list of "cited by" or "citations"
• list of references

When you have thoroughly finished searching a comprehensive database, you can move on to another to find more results. Some databases that cover the same topics might give you the same search results, but they might also cover an entire range of different journals or online resources.

You might prefer the search system of one database over another based on the results you get from keyword searches. One database might have more advanced search options than the other. You can also try a more general database like:

• Web Of Science

➡️ Visit our list of the best academic research databases .

There are experts in every field, people who have published a lot of scholarly content on your topic, people who get quoted or interviewed a lot and seem to be present almost everywhere. Pay attention to those names when searching a database and once you have found someone interesting, you can search for more from that person.

Also, take note of seminal articles, or those works that have been cited repeatedly within your field. Many major databases for academic journals have features that allow you to quickly determine which articles are cited most frequently.

➡️ Ready to start writing your paper? Visit our guide on how to start a research paper .

Your institution's library provides access to plenty of online research databases. They are among the best sources to turn to when you need to find articles from scholarly journals and periodicals.

Searching the right databases is key to finding the right articles. Ask a librarian or check your library's website to access details. If you do not know where to start, check out the three biggest academic database providers:

Or take a look at our compilation of research database for computer science or healthcare .

You can narrow your search by only including articles within a specific date range or unchecking certain types of journals or magazines that are included in the database but have nothing to do with your topic. Make sure to also use very specific keywords when searching.

Unlike in a Google search, typing in full sentences will not bring you satisfactory results. There are different methods to search different databases. Ask a librarian or do an internet search on how to best search your particular database.

Narrowing down a search might not return many results. If you do not get enough results, slowly expand the date range, type of journal, or keywords.

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here .

Find and Read Articles

PLOS publishes a suite of peer-reviewed Open Access journals that feature quality research, expert commentary, and critical analysis across all scientific disciplines.

New Articles by Email

Journal alerts.

PLOS articles publish daily and roll up into monthly issues. To receive a regular email alert with a list of articles published in each issue, sign up at the bottom of any journal homepage.

Choose how often to receive alerts and manage subscriptions from your PLOS account.

• Sign in to your account, then click the Profile button at the top of the page. 
• Navigate to the Alerts tab.
• Under Journal Alerts , check the boxes to choose weekly or monthly delivery.

The weekly email alert from PLOS ONE delivers all new articles by default.

Select Send me a custom email alert to receive articles from specific subject areas. Select one or more subject areas to add them to the email.

Search alerts

Set up a search alert to be notified when new PLOS articles are published relevant to a personalized search. To start, create or sign in to your PLOS account. Read more about PLOS accounts .

Click the link underneath the search box to navigate to the advanced search page.

Customize the search criteria by subject, article type, author, or a variety of other fields. Choose any combination of PLOS journals. 

Once you have a satisfactory set of results, select a delivery method at the top of the page. PLOS offers two delivery methods for these notices: email and RSS feed. Read more about PLOS RSS feeds .

To receive new articles by email, click the  search alert  button. Name the search, choose the email frequency, and click Save .

Unsubscribe

Unsubscribe from email alerts in your PLOS account . Sign in to your account from the top of any journal page, and click the  Profile  button.

Journal alerts Navigate to Alerts > Journal Alerts. ​Uncheck the box to unsubscribe from a specific mailing list.

Saved search alerts Navigate to  Alerts > Search Alerts . Click X  to stop receiving the alert.

New Articles by RSS

PLOS RSS feeds are regular updates with article titles and abstracts, collected in your browser or a feed reader. Use the feeds if you do not want alerts delivered by email but do want to know when new articles are published or added to a saved search. Find out how to create a search alert feed .

RSS feeds are available by clicking the RSS icon on each journal home page. Use any feed reader to collect and read the article list.

Browse by Subject Area

Each PLOS article offers a list of subject area tags based on its subject matter. Click on any term to view other PLOS articles that use the same tag.

Sign up for subject-specific alerts while browsing subject areas on the PLOS ONE site.

• Sign in or create a PLOS account .
• Click the Browse button at the top of any PLOS ONE page.

• Select a subject area from the menu to view the associated articles from PLOS ONE .

• Click the email alert button in the top right corner of the page. Then, click Save  to subscribe.

Sign Up for a PLOS Account

Sign up for a free PLOS account to manage email alerts and post comments on articles.

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Where to find peer reviewed articles for research

This is our ultimate guide to helping you get familiar with your research field and find peer reviewed articles in the Web of Science™. It forms part of our Research Smarter series. 

Finding relevant research and journal articles in your field is critical to a successful research project. Unfortunately, it can be one of the hardest, most time-consuming challenges for academics.

This blog outlines how you can leverage the Web of Science citation network to complete an in-depth, comprehensive search for literature. We share insights about how you can find a research paper and quickly assess its impact. We also explain how to create alerts to keep track of new papers in your field – whether you’re new to the topic or about to embark on a literature review.

• Choosing research databases for your search
• Where to find peer reviewed articles? Master the keyword search
• Filter your results and analyze for trends
• Explore the citation network
• Save your searches and set up alerts for new journal articles

1. Choosing research databases for your search

The myriad search engines, research databases and data repositories all differ in reliability, relevancy and organization of data. This can make it tricky to navigate and assess what’s best for your research at hand.

The Web of Science stands out the most powerful and trusted citation database. It helps you connect ideas and advance scientific research across all fields and disciplines. This is made possible with best-in-class publication and citation data for confident discovery and assessment of journal articles. The Web of Science is also publisher-neutral, carefully-curated by a team of expert editors and consists of 19 different research databases.

The Web of Science Core Collection™ is the single most authoritative source for how to find research articles, discover top authors , and relevant journals . It only includes journals that have met rigorous quality and impact criteria, and it captures billions of cited references from globally significant journals, books and proceedings ( check out its coverage ). Researchers and organizations use this research database regularly to track ideas across disciplines and time.

Explore the Web of Science Core Collection

We recommend spending time exploring the Core Collection specifically because its advanced citation network features are unparalleled. If you are looking to do an exhaustive search of a specific field, you might want to switch to one of the field-specific databases like MEDLINE and INSPEC. You can also select “All databases” from the drop-down box on the main search page. This will cover all research databases your institution subscribes to. IF you are still unsure about where to find scholarly journal articles, you can learn more in our Quick Reference Guide, here, or try it out today.

“We recommend spending time exploring the Core Collection specifically because its advanced citation network features are unparalleled.”

2. Where to find peer reviewed articles? Master the keyword search

A great deal of care and consideration is needed to find peer review articles for research. It starts with your keyword search.

Your chosen keywords or search phrases cannot be too inclusive or limiting. They also require constant iteration as you become more familiar with your research field. Watch this video on search tips to learn more:

It’s worth noting that a repeated keyword search in the same Web of Science database will retrieve almost identical results every time, save for newly-indexed research. Not all research databases do this. If you are conducting a literature review and require a reproducible keyword search, it is best to steer clear of certain databases. For example, a research database that lacks overall transparency or frequently changes its search algorithm may be detrimental to your research.

3. Filter your search results and analyze trends

Group, rank and analyze the research articles in your search results to optimize the relevancy and efficiency of your efforts. In the Web of Science, researchers can cut through the data in a number of creative ways. This will help you when you’re stuck wondering where to find peer reviewed articles, journals and authors. The filter and refine tools , as well as the Analyze Results feature, are all at your disposal for this.

“Group, rank and analyze the research papers in your search results to optimize the relevancy and efficiency of your efforts.”

Filter and Refine tools in the Web of Science

You can opt for basic filter and refine tools in the Web of Science. These include subject category, publication date and open access within your search results. You can also filter by highly-cited research and hot research papers. A hot paper is a journal article that has accumulated rapid and significant numbers of citations over a short period of time.

The Analyze Results tool does much of this and more. It provides an interactive visualization of your results by the most prolific author, institution and funding agency, for example. This, combined, will help you understand trends across your field.

4. Explore the citation network

Keyword searches are essentially an a priori view of the literature. Citation-based searching, on the other hand, leads to “systematic serendipity”. This term was used by Eugene Garfield, the founder of Web of Science. New scientific developments are linked to the global sphere of human knowledge through the citation network. The constantly evolving connections link ideas and lead to systematic serendipity, allowing for all sorts of surprising discoveries.

Exploring the citation network helps you to:

• Identify a seminal research paper in any field. Pay attention to the number of times a journal article is cited to achieve this.
• Track the advancement of research as it progresses over time by analyzing the research papers that cite the original source. This will also help you catch retractions and corrections to research.
• Track the evolution of a research paper backward in time by tracking the work that a particular journal article cites.
• View related references. A research paper may share citations with another piece of work (calculated from bibliographic coupling). That means it’s likely discussing a similar topic.

Visualizing the history discoveries in the citation network

The Web of Science Core Collection indexes every piece of content cover-to-cover. This creates a complete and certain view of more than 115 years of the highest-quality journal articles. The depth of coverage enables you to uncover the historical trail of a research paper in your field. By doing so, it helps you visualize how discoveries unfold through time. You can also learn where they might branch off into new areas of research.  Achieve this in your search by ordering your result set by date of publication.

As PhD student Rachel Ragnhild Carlson (Stanford University) recently wrote in a column for Nature: [1]

”As a PhD student, I’ve learnt to rely not just on my Web of Science research but on numerous conversations with seasoned experts. And I make sure that my reading includes literature from previous decades, which often doesn’t rise to the top of a web search. This practice is reinforced by mentors in my lab, who often find research gems by filtering explicitly for studies greater than ten years old.”

5. Save your search and set up alerts for new journal articles

Save time and keep abreast of new journal articles in your field by saving your searches and setting up email alerts . This means you can return to your search at any time. You can also stay up-to-date about a new research paper included in your search result. This will help you find an article more easily in the future. Head over to Web of Science to try it out today.

“Everyone should set up email alerts with keywords for PubMed, Web of Science, etc. Those keyword lists will evolve and be fine-tuned over time. However, it really helps to get an idea of recent publications.” Thorbjörn Sievert , PhD student, University of Jyväskylä

[1] Ragnhild Carlson, R. 2020 ‘How Trump’s embattled environment agency prepared me for a PhD’, Nature 579, 458

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Library Research at Cornell: Find Articles

• The Research Steps
• Which Topic?
• Find the Context
• Find Articles
• Evaluate Sources
• Cite Sources
• Review the Steps
• Find Primary Sources
• Find Images
• Library Jargon

Tips for Finding Articles

• Use online databases to find articles in journals, newspapers, and magazines (periodicals). You can search for periodical articles by the article author, title, or keyword by using databases in your subject area in Databases .
• Choose the database best suited to your particular topic--see details in the box below.
• Use our Ask a Librarian service for help for figuring out which databases are best for your topic.
• If the article full text is not linked from the citation in the database you are using, search for the title of the periodical in our Catalog . This catalog lists the print, microform, and electronic versions of journals, magazines, and newspapers available in the library.

Finding Periodicals and Periodical Articles

Topic outline for this page:

• What Are Periodicals?

Finding the Periodical When You Do Have the Article Citation

• Locating Periodicals in Olin and Uris Libraries

Distinguishing Scholarly Journals from Other Periodicals

• Evaluating Individual Periodical Titles

What are Periodicals?

Periodicals are continuing publications such as journals, newspapers, or magazines. They are issued regularly (daily, weekly, monthly, or quarterly).

The Cornell Library Catalog includes records for all the periodicals which are received by all the individual units of the Cornell University Library (Music Library, Mann Library, Law Library, Uris Library, etc.).

The Cornell Library Catalog does not include information on individual articles in periodicals. To find individual periodical articles by subject, article author, or article title, use periodical databases .

When you know the periodical title ( Scientific American, The New York Times, Newsweek ) search the Cornell Library Catalog by journal title .

Finding Articles When You Don't Have the Citation

To find an article, use databases.

When you don't have the citation to a specific article, but you do want to find articles on a subject, by a specific author or authors, or with a known article title, you need to use one or more periodical databases . But how do you know which periodical index to use?

What kind of periodicals are you looking for?

• scholarly journals?
• newspapers and substantive news sources?
• popular magazines?
• all three kinds?

[ Learn how to identify scholarly journals, news sources, and popular magazines. ]

If you want articles from scholarly, research, peer-reviewed journals , ask a reference librarian to recommend an index/database for your topic. Some databases index journals exclusively, like America: History and Life , EconLit , Engineering Village , MLA Bibliography , PsycINFO , PubMed , and Web of Science . Google Scholar searches across all scholarly disciplines and subjects. You can also use the subject menu in Databases linked from the library home page to locate databases that index scholarly publications.

If you want newspaper articles , see this guide to newspaper indexes and full-text newspaper databases . Online databases for finding newspaper articles are listed here: News Collections Online: News Databases .

If you want popular magazines , use Academic Search Premier or ProQuest Research Library . A printed index, Reader's Guide to Periodical Literature covering popular magazines from 1890 to 2011 is found in the Olin reference collection (Olin Reference AI 3 .R28).

The online index Reader's Guide Retrospective indexes popular magazines from 1890 to 1982 online. Periodical Contents Index covers some popular magazines for an even broader time period: 1770 to 1993.

If you want an index to all three kinds of articles, use Academic Search Premier or ProQuest Research Library . To find older articles, try Periodical Contents Index ; it indexes periodicals from 1770 to 1993.

If you want to search many databases simultaneously , use Articles & Full Text , also linked from the Library home page .

• If you're not sure which kind of periodical you want or you're not sure which periodical index to use, or if you want help searching, ask a reference librarian .

Remember you can always browse the titles of online periodical databases available online by clicking on this link to the subject categories in the Databases or on the Databases link in the search box on the Library home page .

When You Have a Citation to a Specific Article, Use the Cornell Library Catalog

When you do have the citation or reference to a periodical article--if you know at least the title of the periodical and the issue date of the article you want--you can find its location at Cornell by using the Cornell Library Catalog . Choose "Journal Title" in the drop-down menu to the right of the search box, click in the search box, type in the title of the periodical in the search box, and press <enter> . Don't use the abbreviated titles that are often used in periodical indexes; remember to omit "a," "an" or "the" when you type in the periodical title.

Search examples in the Cornell Library Catalog:

* When searching for the title, Journal of Modern History

Type the following in the search box: journal of modern history

* When searching for the title, Annales Musicologiques: Moyen-Age et Renaissance

You may type the following: annales musicologiques moyen age (Omit punctuation) (searching is not case sensitive)

Depending on the number of records your search retrieves, you will see either a list of entries or a single record for an individual periodical title. If there is a list of titles, scroll through it and click on the line that lists the journal title you want to see for the call number and location information or the online link(s).

If the journal is available in electronic form , there will be a link or links int the box labelled "Availability" in the catalog record. Click on this link. In most cases, this will take you to the opening screen for the journal, and you can choose the issue you want from there.

If the journal is available in print form , record the call number and any additional location information in the catalog record. Now you're ready to find it on the shelf. Consult the local stack directory for the call number locations in individual libraries.

Locating Print Periodicals in Olin and Uris Libraries

Current periodicals:.

Periodicals noted as "Current issues in Periodicals Room" in the Cornell Library Catalog are print journals shelved by title in the Current Periodicals Room on the main level in Olin Library. This room is immediately to the right and down the hall as you enter Olin Library. Only a small selection of current print periodicals is in this room : all other current periodical issues go directly to the Olin stacks where they are shelved by call number.

Back Issues of Periodicals

Back issues of periodicals are shelved by call number in the Olin and Uris Library stacks. Some back periodicals are shelved in specific subject rooms; watch for location notes in the Cornell Library Catalog record for the title you want.

Pay attention to the + and ++ indicators by the call number. Titles with the + and ++ (Oversize) designations and titles with no plus marks are each shelved in separate sections on each floor in Olin Library and separate floors in Uris Library.

Back issues on microfilm, microfiche, and microprint are housed on the lower or B Level in Olin Library.

Journals, news publications, and magazines are important sources for up-to-date information across a wide variety of topics. With a collection as large and diverse as Cornell's it is often difficult to distinguish between the various levels of scholarship found in the collection. In this guide we have divided the criteria for evaluating periodical literature into four categories:

• Scholarly  /  VIDEO: How to Identify Scholarly Journal Articles
• Substantive News and General Interest  /  VIDEO: How to Identify Substantive News Articles
• Sensational and Tabloid

Definitions:

Webster's Third International Dictionary defines scholarly as:

• concerned with academic study, especially research,
• exhibiting the methods and attitudes of a scholar, and
• having the manner and appearance of a scholar.

Substantive is defined as having a solid base, being substantial.

Popular means fit for, or reflecting the taste and intelligence of, the people at large.

Sensational is defined as arousing or intending to arouse strong curiosity, interest or reaction.

Keeping these definitions in mind, and realizing that none of the lines drawn between types of journals can ever be totally clear cut, the general criteria are as follows.

Scholarly journals are also called academic, peer-reviewed, or refereed journals . Strictly speaking, peer-reviewed (also called refereed) journals refer only to those scholarly journals that submit articles to several other scholars, experts, or academics (peers) in the field for review and comment. These reviewers must agree that the article represents properly conducted original research or writing before it can be published.

To check if a journal is peer-reviewed/refereed, search the journal by title in Ulrich's Periodical Directory --look for the referee jersey icon.

What to look for:

• Scholarly journal articles often have an abstract, a descriptive summary of the article contents, before the main text of the article.
• Scholarly journals generally have a sober, serious look. They often contain many graphs and charts but few glossy pages or exciting pictures.
• Scholarly journals always cite their sources in the form of footnotes or bibliographies. These bibliographies are generally lengthy and cite other scholarly writings.
• Articles are written by a scholar in the field or by someone who has done research in the field. The affiliations of the authors are listed, usually at the bottom of the first page or at the end of the article--universities, research institutions, think tanks, and the like.
• The language of scholarly journals is that of the discipline covered. It assumes some technical background on the part of the reader.
• The main purpose of a scholarly journal is to report on original research or experimentation in order to make such information available to the rest of the scholarly world.
• Many scholarly journals, though by no means all, are published by a specific professional organization.

Examples of Scholarly Journals:

• American Economic Review
• Applied Geography
• Archives of Sexual Behavior
• JAMA : The Journal of the American Medical Association
• Journal of Marriage and the Family (published by the National Council on Family Relations)
• Journal of Theoretical Biology
• Modern Fiction Studies

Substantive News or General Interest

These periodicals may be quite attractive in appearance, although some are in newspaper format. Articles are often heavily illustrated, generally with photographs.

News and general interest periodicals sometimes cite sources, though more often do not.

Articles may be written by a member of the editorial staff, a scholar or a free lance writer.

The language of these publications is geared to any educated audience. There is no specialty assumed, only interest and a certain level of intelligence.

They are generally published by commercial enterprises or individuals, although some emanate from specific professional organizations.

The main purpose of periodicals in this category is to provide information, in a general manner, to a broad audience of concerned citizens.

Examples of Substantive News and General Interest Periodicals:

• The Economist
• National Geographic
• The New York Times
• Scientific American
• Vital Speeches of the Day

Popular periodicals come in many formats, although often slick and attractive in appearance with lots of color graphics (photographs, drawings, etc.).

These publications do not cite sources in a bibliography. Information published in popular periodicals is often second or third hand and the original source is rarely mentioned.

Articles are usually very short and written in simple language.

The main purpose of popular periodicals is to entertain the reader, to sell products (their own or their advertisers), or to promote a viewpoint.

Examples of Popular Periodicals:

• People Weekly
• Readers Digest
• Sports Illustrated

Sensational or Tabloid

Sensational periodicals come in a variety of styles, but often use a newspaper format.

Their language is elementary and occasionally inflammatory. They assume a certain gullibility in their audience.

The main purpose of sensational magazines seems to be to arouse curiosity and to cater to popular superstitions. They often do so with flashy headlines designed to astonish (e.g., Half-man Half-woman Makes Self Pregnant).

Examples of Sensational Periodicals:

• National Examiner
• Weekly World News

Evaluating Periodicals: Magazines for Libraries

Magazines for Libraries describes and evaluates journals, magazines, and newspapers:

Or ask for assistance at the reference desk .

Reference Help

• << Previous: Find Books
• Next: Evaluate Sources >>
• Last Updated: Mar 22, 2024 11:29 AM
• URL: https://guides.library.cornell.edu/sevensteps

• EXPLORE Random Article

How to Find Research Articles

Last Updated: May 21, 2023 References

This article was co-authored by Kim Gillingham, MA and by wikiHow staff writer, Jennifer Mueller, JD . Kim Gillingham is a retired library and information specialist with over 30 years of experience. She has a Master's in Library Science from Kutztown University in Pennsylvania, and she managed the audiovisual department of the district library center in Montgomery County, Pennsylvania, for 12 years. She continues to do volunteer work for various libraries and lending library projects in her local community. There are 7 references cited in this article, which can be found at the bottom of the page. This article has been viewed 11,624 times.

If you need original research for a paper or other project, chances are you're going to be looking for scholarly journals. Most of these journals are digitized and available online. However, not all are available for free. Many are contained in databases that require a subscription to access. Once you've found a research article you think you might be able to use, you'll also want to make certain that the article you're reading is primary research. In the sciences, a primary research article discusses a study conducted by the authors of the article and the results of that study, rather than merely summarizing the findings of others. [1] X Research source

Using Free Academic Search Engines

• ScienceDirect ( http://www.sciencedirect.com/science/search ): covers all science and medical disciplines
• IEEE Xplore ( http://ieeexplore.ieee.org/Xplore/guesthome.jsp ): covers computer sciences, electronics, and electrical engineering

Warning: Most academic search engines only provide you the link to a citation and abstract, not the full text of the article. However, you can read the abstract to determine if the article would be helpful for you.

• The guides will tell you how to search the most efficiently, including symbols and punctuation you can add to your searches to limit them and weed out unhelpful results.

• Read the abstract and any other information available about the article to find out if it might be of help to you. Then search the title in quotation marks. If the full text of the article is available on the internet, you'll be able to find it with this search.
• Keep in mind that this search will pull up any pages where the title of the article appears, many of which likely won't include the full text of the article. You may have to dig through a few links to find the full text.
• Some of the links you find will be to a subscription-based database with a paywall. These sites typically won't let you view more than the abstract for free.

Tip: As you're scrolling your search results, look for a link with a PDF extension. These are more likely to be the full text of the article.

• These browser extensions search the web for a full-text copy of the article on the internet. They don't "hack" subscription databases or allow you to access articles illegally. Rather, they search for free copies of the article that already exist.
• For example, the author of the article might have uploaded a PDF of the article on their own website or on their university faculty page. The browser extensions may help you find the article more quickly than you could on your own.

Accessing Scholarly Databases

• If you've already graduated, find out if you can get alumni access to scholarly databases.

Tip: If you're not affiliated with a college or university, talk to the research librarian at your public library. Public libraries often have scholarly database subscriptions as well.

• PubMed ( https://www.ncbi.nlm.nih.gov/pubmed/ ): offered by the National Center for Biotechnology Information in the US. Not all of the articles are free, but you can limit your search to full-text articles.
• Education Resources Information Center (ERIC) ( https://eric.ed.gov/ ): maintained by the Institution of Education Sciences in the US. Not all articles are free, but you can limit your search to full-text.
• NASA Scientific and Technical Information ( https://www.sti.nasa.gov/ ): Provides full-text scientific articles and data sets.

• CORE ( https://core.ac.uk/ ): more than 66 million open access scholarly articles
• ScienceOpen ( https://www.scienceopen.com/ ): more than 28 million articles across all science disciplines
• Directory of Open Access Journals ( https://doaj.org/ ): more than 2 million articles from 9,519 open access journals; multidisciplinary
• Public Library of Science (PLOS) ( https://www.plos.org/ ): publishes 7 open access journals in science fields

Identifying Articles about Primary Research

• The record frequently includes keywords and search terms. Some of these might give you an indication that the article presents original research. For example, one of the keywords or phrases might be "primary research" or "original research." Also, look for words that indicate something new was discovered as a result of the research.
• The title of the article can also help you figure out whether it presents original research. Look for scientific methodology words, such as "sample," which indicate a study was performed.

Tip: If you see an article with the word "review" in the title, it typically does not present original research. However, it does provide an overview and analysis of several studies on the same subject. You can use it to see if any of those studies would help you, then look for those articles.

• If the abstract is written in the first person, you can be assured that the author or authors of the article are going to be talking about a study they conducted themselves. However, many abstracts are written in passive voice to avoid using the first person.

Tip: Use the references to find other primary research articles that the author or authors relied upon when presenting their own findings.

• You can also use the charts and graphs to quickly evaluate the study and determine if the article would be beneficial for you in your paper or project.

Expert Q&A

You might also like.

Expert Interview

Thanks for reading our article! If you’d like to learn more about research, check out our in-depth interview with Kim Gillingham, MA .

• ↑ https://suffolk.libguides.com/c.php?g=654047&p=4589820
• ↑ https://www.sciencebuddies.org/science-fair-projects/competitions/finding-and-accessing-scientific-papers
• ↑ Jeremiah Kaplan. Research & Training Specialist. Expert Interview. 2 September 2021.
• ↑ Kim Gillingham, MA. Master's Degree, Library Science, Kutztown University. Expert Interview. 15 May 2019.
• ↑ https://umb.libguides.com/c.php?g=351041&p=2368605
• ↑ https://www.scribendi.com/advice/free_online_journal_and_research_databases.en.html
• ↑ http://umb.libanswers.com/faq/146414

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A systematic approach to searching: an efficient and complete method to develop literature searches

Associated data.

Creating search strategies for systematic reviews, finding the best balance between sensitivity and specificity, and translating search strategies between databases is challenging. Several methods describe standards for systematic search strategies, but a consistent approach for creating an exhaustive search strategy has not yet been fully described in enough detail to be fully replicable. The authors have established a method that describes step by step the process of developing a systematic search strategy as needed in the systematic review. This method describes how single-line search strategies can be prepared in a text document by typing search syntax (such as field codes, parentheses, and Boolean operators) before copying and pasting search terms (keywords and free-text synonyms) that are found in the thesaurus. To help ensure term completeness, we developed a novel optimization technique that is mainly based on comparing the results retrieved by thesaurus terms with those retrieved by the free-text search words to identify potentially relevant candidate search terms. Macros in Microsoft Word have been developed to convert syntaxes between databases and interfaces almost automatically. This method helps information specialists in developing librarian-mediated searches for systematic reviews as well as medical and health care practitioners who are searching for evidence to answer clinical questions. The described method can be used to create complex and comprehensive search strategies for different databases and interfaces, such as those that are needed when searching for relevant references for systematic reviews, and will assist both information specialists and practitioners when they are searching the biomedical literature.

INTRODUCTION

Librarians and information specialists are often involved in the process of preparing and completing systematic reviews (SRs), where one of their main tasks is to identify relevant references to include in the review [ 1 ]. Although several recommendations for the process of searching have been published [ 2 – 6 ], none describe the development of a systematic search strategy from start to finish.

Traditional methods of SR search strategy development and execution are highly time consuming, reportedly requiring up to 100 hours or more [ 7 , 8 ]. The authors wanted to develop systematic and exhaustive search strategies more efficiently, while preserving the high sensitivity that SR search strategies necessitate. In this article, we describe the method developed at Erasmus University Medical Center (MC) and demonstrate its use through an example search. The efficiency of the search method and outcome of 73 searches that have resulted in published reviews are described in a separate article [ 9 ].

As we aimed to describe the creation of systematic searches in full detail, the method starts at a basic level with the analysis of the research question and the creation of search terms. Readers who are new to SR searching are advised to follow all steps described. More experienced searchers can consider the basic steps to be existing knowledge that will already be part of their normal workflow, although step 4 probably differs from general practice. Experienced searchers will gain the most from reading about the novelties in the method as described in steps 10–13 and comparing the examples given in the supplementary appendix to their own practice.

CREATING A SYSTEMATIC SEARCH STRATEGY

Our methodology for planning and creating a multi-database search strategy consists of the following steps:

• Determine a clear and focused question
• Describe the articles that can answer the question
• Decide which key concepts address the different elements of the question
• Decide which elements should be used for the best results
• Choose an appropriate database and interface to start with
• Document the search process in a text document
• Identify appropriate index terms in the thesaurus of the first database
• Identify synonyms in the thesaurus
• Add variations in search terms
• Use database-appropriate syntax, with parentheses, Boolean operators, and field codes
• Optimize the search
• Evaluate the initial results
• Check for errors
• Translate to other databases
• Test and reiterate

Each step in the process is reflected by an example search described in the supplementary appendix .

1. Determine a clear and focused question

A systematic search can best be applied to a well-defined and precise research or clinical question. Questions that are too broad or too vague cannot be answered easily in a systematic way and will generally result in an overwhelming number of search results. On the other hand, a question that is too specific will result into too few or even zero search results. Various papers describe this process in more detail [ 10 – 12 ].

2. Describe the articles that can answer the question

Although not all clinical or research questions can be answered in the literature, the next step is to presume that the answer can indeed be found in published studies. A good starting point for a search is hypothesizing what the research that can answer the question would look like. These hypothetical (when possible, combined with known) articles can be used as guidance for constructing the search strategy.

3. Decide which key concepts address the different elements of the question

Key concepts are the topics or components that the desired articles should address, such as diseases or conditions, actions, substances, settings, domains (e.g., therapy, diagnosis, etiology), or study types. Key concepts from the research question can be grouped to create elements in the search strategy.

Elements in a search strategy do not necessarily follow the patient, intervention, comparison, outcome (PICO) structure or any other related structure. Using the PICO or another similar framework as guidance can be helpful to consider, especially in the inclusion and exclusion review stage of the SR, but this is not necessary for good search strategy development [ 13 – 15 ]. Sometimes concepts from different parts of the PICO structure can be grouped together into one search element, such as when the desired outcome is frequently described in a certain study type.

4. Decide which elements should be used for the best results

Not all elements of a research question should necessarily be used in the search strategy. Some elements are less important than others or may unnecessarily complicate or restrict a search strategy. Adding an element to a search strategy increases the chance of missing relevant references. Therefore, the number of elements in a search strategy should remain as low as possible to optimize recall.

Using the schema in Figure 1 , elements can be ordered by their specificity and importance to determine the best search approach. Whether an element is more specific or more general can be measured objectively by the number of hits retrieved in a database when searching for a key term representing that element. Depending on the research question, certain elements are more important than others. If articles (hypothetically or known) exist that can answer the question but lack a certain element in their titles, abstracts, or keywords, that element is unimportant to the question. An element can also be unimportant because of expected bias or an overlap with another element.

Schema for determining the optimal order of elements

Bias in elements

The choice of elements in a search strategy can introduce bias through use of overly specific terminology or terms often associated with positive outcomes. For the question “does prolonged breastfeeding improve intelligence outcomes in children?,” searching specifically for the element of duration will introduce bias, as articles that find a positive effect of prolonged breastfeeding will be much more likely to mention time factors in their titles or abstracts.

Overlapping elements

Elements in a question sometimes overlap in their meaning. Sometimes certain therapies are interventions for one specific disease. The Lichtenstein technique, for example, is a repair method for inguinal hernias. There is no need to include an element of “inguinal hernias” to a search for the effectiveness of the Lichtenstein therapy. Likewise, sometimes certain diseases are only found in certain populations. Adding such an overlapping element could lead to missing relevant references.

The elements to use in a search strategy can be found in the plot of elements in Figure 1 , by following the top row from left to right. For this method, we recommend starting with the most important and specific elements. Then, continue with more general and important elements until the number of results is acceptable for screening. Determining how many results are acceptable for screening is often a matter of negotiation with the SR team.

5. Choose an appropriate database and interface to start with

Important factors for choosing databases to use are the coverage and the presence of a thesaurus. For medically oriented searches, the coverage and recall of Embase, which includes the MEDLINE database, are superior to those of MEDLINE [ 16 ]. Each of these two databases has its own thesaurus with its own unique definitions and structure. Because of the complexity of the Embase thesaurus, Emtree, which contains much more specific thesaurus terms than the MEDLINE Medical Subject Headings (MeSH) thesaurus, translation from Emtree to MeSH is easier than the other way around. Therefore, we recommend starting in Embase.

MEDLINE and Embase are available through many different vendors and interfaces. The choice of an interface and primary database is often determined by the searcher’s accessibility. For our method, an interface that allows searching with proximity operators is desirable, and full functionality of the thesaurus, including explosion of narrower terms, is crucial. We recommend developing a personal workflow that always starts with one specific database and interface.

6. Document the search process in a text document

We advise designing and creating the complete search strategies in a log document, instead of directly in the database itself, to register the steps taken and to make searches accountable and reproducible. The developed search strategies can be copied and pasted into the desired databases from the log document. This way, the searcher is in control of the whole process. Any change to the search strategy should be done in the log document, assuring that the search strategy in the log is always the most recent.

7. Identify appropriate index terms in the thesaurus of the first database

Searches should start by identifying appropriate thesaurus terms for the desired elements. The thesaurus of the database is searched for matching index terms for each key concept. We advise restricting the initial terms to the most important and most relevant terms. Later in the process, more general terms can be added in the optimization process, in which the effect on the number of hits, and thus the desirability of adding these terms, can be evaluated more easily.

Several factors can complicate the identification of thesaurus terms. Sometimes, one thesaurus term is found that exactly describes a specific element. In contrast, especially in more general elements, multiple thesaurus terms can be found to describe one element. If no relevant thesaurus terms have been found for an element, free-text terms can be used, and possible thesaurus terms found in the resulting references can be added later (step 11).

Sometimes, no distinct thesaurus term is available for a specific key concept that describes the concept in enough detail. In Emtree, one thesaurus term often combines two or more elements. The easiest solution for combining these terms for a sensitive search is to use such a thesaurus term in all elements where it is relevant. Examples are given in the supplementary appendix .

8. Identify synonyms in the thesaurus

Most thesauri offer a list of synonyms on their term details page (named Synonyms in Emtree and Entry Terms in MeSH). To create a sensitive search strategy for SRs, these terms need to be searched as free-text keywords in the title and abstract fields, in addition to searching their associated thesaurus terms.

The Emtree thesaurus contains more synonyms (300,000) than MeSH does (220,000) [ 17 ]. The difference in number of terms is even higher considering that many synonyms in MeSH are permuted terms (i.e., inversions of phrases using commas).

Thesaurus terms are ordered in a tree structure. When searching for a more general thesaurus term, the more specific (narrower) terms in the branches below that term will also be searched (this is frequently referred to as “exploding” a thesaurus term). However, to perform a sensitive search, all relevant variations of the narrower terms must be searched as free-text keywords in the title or abstract, in addition to relying on the exploded thesaurus term. Thus, all articles that describe a certain narrower topic in their titles and abstracts will already be retrieved before MeSH terms are added.

9. Add variations in search terms (e.g., truncation, spelling differences, abbreviations, opposites)

Truncation allows a searcher to search for words beginning with the same word stem. A search for therap* will, thus, retrieve therapy, therapies, therapeutic, and all other words starting with “therap.” Do not truncate a word stem that is too short. Also, limitations of interfaces should be taken into account, especially in PubMed, where the number of search term variations that can be found by truncation is limited to 600.

Databases contain references to articles using both standard British and American English spellings. Both need to be searched as free-text terms in the title and abstract. Alternatively, many interfaces offer a certain code to replace zero or one characters, allowing a search for “pediatric” or “paediatric” as “p?ediatric.” Table 1 provides a detailed description of the syntax for different interfaces.

Field codes in five most used interfaces for biomedical literature searching

Searching for abbreviations can identify extra, relevant references and retrieve more irrelevant ones. The search can be more focused by combining the abbreviation with an important word that is relevant to its meaning or by using the Boolean “NOT” to exclude frequently observed, clearly irrelevant results. We advise that searchers do not exclude all possible irrelevant meanings, as it is very time consuming to identify all the variations, it will result in unnecessarily complicated search strategies, and it may lead to erroneously narrowing the search and, thereby, reduce recall.

Searching partial abbreviations can be useful for retrieving relevant references. For example, it is very likely that an article would mention osteoarthritis (OA) early in the abstract, replacing all further occurrences of osteoarthritis with OA . Therefore, it may not contain the phrase “hip osteoarthritis” but only “hip oa.”

It is also important to search for the opposites of search terms to avoid bias. When searching for “disease recurrence,” articles about “disease free” may be relevant as well. When the desired outcome is survival , articles about mortality may be relevant.

10. Use database-appropriate syntax, with parentheses, Boolean operators, and field codes

Different interfaces require different syntaxes, the special set of rules and symbols unique to each database that define how a correctly constructed search operates. Common syntax components include the use of parentheses and Boolean operators such as “AND,” “OR,” and “NOT,” which are available in all major interfaces. An overview of different syntaxes for four major interfaces for bibliographic medical databases (PubMed, Ovid, EBSCOhost, Embase.com, and ProQuest) is shown in Table 1 .

Creating the appropriate syntax for each database, in combination with the selected terms as described in steps 7–9, can be challenging. Following the method outlined below simplifies the process:

• Create single-line queries in a text document (not combining multiple record sets), which allows immediate checking of the relevance of retrieved references and efficient optimization.
• Type the syntax (Boolean operators, parentheses, and field codes) before adding terms, which reduces the chance that errors are made in the syntax, especially in the number of parentheses.
• Use predefined proximity structures including parentheses, such as (() ADJ3 ()) in Ovid, that can be reused in the query when necessary.
• Use thesaurus terms separately from free-text terms of each element. Start an element with all thesaurus terms (using “OR”) and follow with the free-text terms. This allows the unique optimization methods as described in step 11.
• When adding terms to an existing search strategy, pay close attention to the position of the cursor. Make sure to place it appropriately either in the thesaurus terms section, in the title/abstract section, or as an addition (broadening) to an existing proximity search.

The supplementary appendix explains the method of building a query in more detail, step by step for different interfaces: PubMed, Ovid, EBSCOhost, Embase.com, and ProQuest. This method results in a basic search strategy designed to retrieve some relevant references upon which a more thorough search strategy can be built with optimization such as described in step 11.

11. Optimize the search

The most important question when performing a systematic search is whether all (or most) potentially relevant articles have been retrieved by the search strategy. This is also the most difficult question to answer, since it is unknown which and how many articles are relevant. It is, therefore, wise first to broaden the initial search strategy, making the search more sensitive, and then check if new relevant articles are found by comparing the set results (i.e., search for Strategy #2 NOT Strategy #1 to see the unique results).

A search strategy should be tested for completeness. Therefore, it is necessary to identify extra, possibly relevant search terms and add them to the test search in an OR relationship with the already used search terms. A good place to start, and a well-known strategy, is scanning the top retrieved articles when sorted by relevance, looking for additional relevant synonyms that could be added to the search strategy.

We have developed a unique optimization method that has not been described before in the literature. This method often adds valuable extra terms to our search strategy and, therefore, extra, relevant references to our search results. Extra synonyms can be found in articles that have been assigned a certain set of thesaurus terms but that lack synonyms in the title and/or abstract that are already present in the current search strategy. Searching for thesaurus terms NOT free-text terms will help identify missed free-text terms in the title or abstract. Searching for free-text terms NOT thesaurus terms will help identify missed thesaurus terms. If this is done repeatedly for each element, leaving the rest of the query unchanged, this method will help add numerous relevant terms to the query. These steps are explained in detail for five different search platforms in the supplementary appendix .

12. Evaluate the initial results

The results should now contain relevant references. If the interface allows relevance ranking, use that in the evaluation. If you know some relevant references that should be included in the research, search for those references specifically; for example, combine a specific (first) author name with a page number and the publication year. Check whether those references are retrieved by the search. If the known relevant references are not retrieved by the search, adapt the search so that they are. If it is unclear which element should be adapted to retrieve a certain article, combine that article with each element separately.

Different outcomes are desired for different types of research questions. For instance, in the case of clinical question answering, the researcher will not be satisfied with many references that contain a lot of irrelevant references. A clinical search should be rather specific and is allowed to miss a relevant reference. In the case of an SR, the researchers do not want to miss any relevant reference and are willing to handle many irrelevant references to do so. The search for references to include in an SR should be very sensitive: no included reference should be missed. A search that is too specific or too sensitive for the intended goal can be adapted to become more sensitive or specific. Steps to increase sensitivity or specificity of a search strategy can be found in the supplementary appendix .

13. Check for errors

Errors might not be easily detected. Sometimes clues can be found in the number of results, either when the number of results is much higher or lower than expected or when many retrieved references are not relevant. However, the number expected is often unknown, and very sensitive search strategies will always retrieve many irrelevant articles. Each query should, therefore, be checked for errors.

One of the most frequently occurring errors is missing the Boolean operator “OR.” When no “OR” is added between two search terms, many interfaces automatically add an “AND,” which unintentionally reduces the number of results and likely misses relevant references. One good strategy to identify missing “OR”s is to go to the web page containing the full search strategy, as translated by the database, and using Ctrl-F search for “AND.” Check whether the occurrences of the “AND” operator are deliberate.

Ideally, search strategies should be checked by other information specialists [ 18 ]. The Peer Review of Electronic Search Strategies (PRESS) checklist offers good guidance for this process [ 4 ]. Apart from the syntax (especially Boolean operators and field codes) of the search strategy, it is wise to have the search terms checked by the clinician or researcher familiar with the topic. At Erasmus MC, researchers and clinicians are involved during the complete process of structuring and optimizing the search strategy. Each word is added after the combined decision of the searcher and the researcher, with the possibility of directly comparing results with and without the new term.

14. Translate to other databases

To retrieve as many relevant references as possible, one has to search multiple databases. Translation of complex and exhaustive queries between different databases can be very time consuming and cumbersome. The single-line search strategy approach detailed above allows quick translations using the find and replace method in Microsoft Word (<Ctrl-H>).

At Erasmus MC, macros based on the find-and-replace method in Microsoft Word have been developed for easy and fast translation between the most used databases for biomedical and health sciences questions. The schema that is followed for the translation between databases is shown in Figure 2 . Most databases simply follow the structure set by the Embase.com search strategy. The translation from Emtree terms to MeSH terms for MEDLINE in Ovid often identifies new terms that need to be added to the Embase.com search strategy before the translation to other databases.

Schematic representation of translation between databases used at Erasmus University Medical Center

Dotted lines represent databases that are used in less than 80% of the searches.

Using five different macros, a thoroughly optimized query in Embase.com can be relatively quickly translated into eight major databases. Basic search strategies will be created to use in many, mostly smaller, databases, because such niche databases often do not have extensive thesauri or advanced syntax options. Also, there is not much need to use extensive syntax because the number of hits and, therefore, the amount of noise in these databases is generally low. In MEDLINE (Ovid), PsycINFO (Ovid), and CINAHL (EBSCOhost), the thesaurus terms must be adapted manually, as each database has its own custom thesaurus. These macros and instructions for their installation, use, and adaptation are available at bit.ly/databasemacros.

15. Test and reiterate

Ideally, exhaustive search strategies should retrieve all references that are covered in a specific database. For SR search strategies, checking searches for their recall is advised. This can be done after included references have been determined by the authors of the systematic review. If additional papers have been identified through other non-database methods (i.e., checking references in included studies), results that were not identified by the database searches should be examined. If these results were available in the databases but not located by the search strategy, the search strategy should be adapted to try to retrieve these results, as they may contain terms that were omitted in the original search strategies. This may enable the identification of additional relevant results.

A methodology for creating exhaustive search strategies has been created that describes all steps of the search process, starting with a question and resulting in thorough search strategies in multiple databases. Many of the steps described are not new, but together, they form a strong method creating high-quality, robust searches in a relatively short time frame.

Our methodology is intended to create thoroughness for literature searches. The optimization method, as described in step 11, will identify missed synonyms or thesaurus terms, unlike any other method that largely depends on predetermined keywords and synonyms. Using this method results in a much quicker search process, compared to traditional methods, especially because of the easier translation between databases and interfaces (step 13). The method is not a guarantee for speed, since speed depends on many factors, including experience. However, by following the steps and using the tools as described above, searchers can gain confidence first and increase speed through practice.

What is new?

This method encourages searchers to start their search development process using empty syntax first and later adding the thesaurus terms and free-text synonyms. We feel this helps the searcher to focus on the search terms, instead of on the structure of the search query. The optimization method in which new terms are found in the already retrieved articles is used in some other institutes as well but has to our knowledge not been described in the literature. The macros to translate search strategies between interfaces are unique in this method.

What is different compared to common practice?

Traditionally, librarians and information specialists have focused on creating complex, multi-line (also called line-by-line) search strategies, consisting of multiple record sets, and this method is frequently advised in the literature and handbooks [ 2 , 19 – 21 ]. Our method, instead, uses single-line searches, which is critical to its success. Single-line search strategies can be easily adapted by adding or dropping a term without having to recode numbers of record sets, which would be necessary in multi-line searches. They can easily be saved in a text document and repeated by copying and pasting for search updates. Single-line search strategies also allow easy translation to other syntaxes using find-and-replace technology to update field codes and other syntax elements or using macros (step 13).

When constructing a search strategy, the searcher might experience that certain parentheses in the syntax are unnecessary, such as parentheses around all search terms in the title/abstract portion, if there is only one such term, there are double parentheses in the proximity statement, or one of the word groups exists for only one word. One might be tempted to omit those parentheses for ease of reading and management. However, during the optimization process, the searcher is likely to find extra synonyms that might consist of one word. To add those terms to the first query (with reduced parentheses) requires adding extra parentheses (meticulously placing and counting them), whereas, in the latter search, it only requires proper placement of those terms.

Many search methods highly depend on the PICO framework. Research states that often PICO or PICOS is not suitable for every question [ 22 , 23 ]. There are other acronyms than PICO—such as sample, phenomenon of interest, design, evaluation, research type (SPIDER) [ 24 ]—but each is just a variant. In our method, the most important and specific elements of a question are being analyzed for building the best search strategy.

Though it is generally recommended that searchers search both MEDLINE and Embase, most use MEDLINE as the starting point. It is considered the gold standard for biomedical searching, partially due to historical reasons, since it was the first of its kind, and more so now that it is freely available via the PubMed interface. Our method can be used with any database as a starting point, but we use Embase instead of MEDLINE or another database for a number of reasons. First, Embase provides both unique content and the complete content of MEDLINE. Therefore, searching Embase will be, by definition, more complete than searching MEDLINE only. Second, the number of terms in Emtree (the Embase thesaurus) is three times as high as that of MeSH (the MEDLINE thesaurus). It is easier to find MeSH terms after all relevant Emtree terms have been identified than to start with MeSH and translate to Emtree.

At Erasmus MC, the researchers sit next to the information specialist during most of the search strategy design process. This way, the researchers can deliver immediate feedback on the relevance of proposed search terms and retrieved references. The search team then combines knowledge about databases with knowledge about the research topic, which is an important condition to create the highest quality searches.

Limitations of the method

One disadvantage of single-line searches compared to multi-line search strategies is that errors are harder to recognize. However, with the methods for optimization as described (step 11), errors are recognized easily because missed synonyms and spelling errors will be identified during the process. Also problematic is that more parentheses are needed, making it more difficult for the searcher and others to assess the logic of the search strategy. However, as parentheses and field codes are typed before the search terms are added (step 10), errors in parentheses can be prevented.

Our methodology works best if used in an interface that allows proximity searching. It is recommended that searchers with access to an interface with proximity searching capabilities select one of those as the initial database to develop and optimize the search strategy. Because the PubMed interface does not allow proximity searches, phrases or Boolean “AND” combinations are required. Phrase searching complicates the process and is more specific, with the higher risk of missing relevant articles, and using Boolean “AND” combinations increases sensitivity but at an often high loss of specificity. Due to some searchers’ lack of access to expensive databases or interfaces, the freely available PubMed interface may be necessary to use, though it should never be the sole database used for an SR [ 2 , 16 , 25 ]. A limitation of our method is that it works best with subscription-based and licensed resources.

Another limitation is the customization of the macros to a specific institution’s resources. The macros for the translation between different database interfaces only work between the interfaces as described. To mitigate this, we recommend using the find-and-replace functionality of text editors like Microsoft Word to ease the translation of syntaxes between other databases. Depending on one’s institutional resources, custom macros can be developed using similar methods.

Results of the method

Whether this method results in exhaustive searches where no important article is missed is difficult to determine, because the number of relevant articles is unknown for any topic. A comparison of several parameters of 73 published reviews that were based on a search developed with this method to 258 reviews that acknowledged information specialists from other Dutch academic hospitals shows that the performance of the searches following our method is comparable to those performed in other institutes but that the time needed to develop the search strategies was much shorter than the time reported for the other reviews [ 9 ].

CONCLUSIONS

With the described method, searchers can gain confidence in their search strategies by finding many relevant words and creating exhaustive search strategies quickly. The approach can be used when performing SR searches or for other purposes such as answering clinical questions, with different expectations of the search’s precision and recall. This method, with practice, provides a stepwise approach that facilitates the search strategy development process from question clarification to final iteration and beyond.

SUPPLEMENTAL FILE

Acknowledgments.

We highly appreciate the work that was done by our former colleague Louis Volkers, who in his twenty years as an information specialist in Erasmus MC laid the basis for our method. We thank Professor Oscar Franco for reviewing earlier drafts of this article.

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Many Americans find value in getting news on social media, but concerns about inaccuracy have risen

Social media plays a crucial role in Americans’ news consumption . Half of all U.S. adults say they at least sometimes get news there, according to a 2023 Pew Research Center survey .

Those who get news on social media name a variety of things that they like about it, including convenience, speed and the element of social interaction. But some social media news consumers also express concerns about news there being inaccurate, low quality and politically biased. The share who say inaccuracy is the aspect they dislike most has increased from 31% to 40% in the past five years.

These findings come from a broader Center survey of U.S. adults’ news habits . The survey asked Americans who get news on social media to describe – in their own words – the things they like and dislike most about getting news there. Their responses were then sorted into categories.

Pew Research Center asked two open-ended questions about what people like and dislike most about getting news on social media as part of a survey on U.S. adults’ news habits. The survey of 8,842 U.S. adults was conducted from Sept. 25 to Oct. 1, 2023.

Everyone who completed the survey is a member of the Center’s American Trends Panel (ATP), an online survey panel that is recruited through national, random sampling of residential addresses. This way nearly all U.S. adults have a chance of selection. The survey is weighted to be representative of the U.S. adult population by gender, race, ethnicity, partisan affiliation, education and other categories. Read more about the  ATP’s methodology .

We asked all respondents who say they get news on social media to answer the open-ended questions. Responses were manually coded into categories. In total, we coded 4,507 open-end responses on what respondents like the most and 4,453 responses on what respondents dislike the most.

Here are the  questions used for the fall 2023 survey , along with responses, and its  methodology .

We asked whether Americans prefer social media or news outlets for various types of information on a separate ATP survey conducted March 20-26, 2023, among 3,576 U.S. adults. Here are the questions used for the spring 2023 survey , along with responses, and its  methodology .

Pew Research Center is a subsidiary of The Pew Charitable Trusts, its primary funder. This is the latest report in Pew Research Center’s ongoing investigation of the state of news, information and journalism in the digital age, a research program funded by The Pew Charitable Trusts, with generous support from the John S. and James L. Knight Foundation.

What Americans like about getting news on social media

The aspects of getting news on social media that Americans value have not changed much since 2018 , the last time we asked these questions. Convenience remains the top thing people like most about getting news on social media. One-in-five social media news consumers say this, with responses such as “It’s at my fingertips,” “I can easily get it” and “It’s available all the time and anywhere.”

Another 9% say they like the speed with which they can get news there, describing news on social media as “fast and to the point” and “quick and easy to digest.”

Smaller shares say they like interaction with others , the up-to-date nature of the news, the content or format , and the variety of sources and stories .

Meanwhile, 7% of Americans who get news on social media say they don’t like anything about the experience, and an additional 32% did not offer a response.

What Americans dislike about getting news on social media

Many social media news consumers also see downsides to getting news this way. Four-in-ten Americans who get news from social media say inaccuracy is the thing they dislike most about it – an increase of 9 percentage points since 2018. This category of responses includes concerns about unverified facts, misinformation, “fake news” and unreliable sources.

A much smaller share of social media news consumers (8%) say they dislike the low quality of news there, with some giving clickbait or a lack of in-depth coverage as examples. Others say the news on social media is too biased or political (6%) or they don’t like the way people behave there (5%).

Another 1% of social media news consumers say censorship is what they dislike most. This category – which we used for the first time in the 2023 survey – includes responses such as “Too much censorship by the sites” and “I really dislike when some of my view points are removed.” There are no significant differences in the shares of Democratic and Republican social media news consumers who say they’re concerned about news censorship on social media. In fact, there are no partisan differences within any of these complaint categories.

Just 4% of respondents say they don’t dislike anything about getting news on social media. Another 31% did not answer the question.

Social media posts versus news outlets: Which do Americans prefer for certain types of information?

The perceived downsides of getting news on social media may help explain why many Americans prefer to go directly to news outlets instead. In a separate Center survey, U.S. adults who say they at least sometimes get news on social media were asked whether they prefer reading social media posts or going directly to news outlets for five different types of information. Those types of information include the basic facts about an issue or event as well as in-depth information and opinions on it.

Americans prefer to get four of the five types of information from news outlets over social media. However, a substantial share say they like getting each type of information from news outlets and social media about the same.

For example, 45% of respondents say they prefer news outlets for getting the most in-depth information about an issue or event, while only 11% prefer social media posts for this. An additional 34% say they value both sources equally, while 8% say they prefer neither option.

Social media news consumers also tend to prefer news outlets over social media to get:

• The basic facts about an issue or event (39% vs. 14%)
• Up-to-date information about an event as it is happening (34% vs. 21%)
• Information about how an issue or event impacts them (31% vs. 15%)

In each of these cases, roughly four-in-ten or more say they like social media and news outlets about the same.

In contrast, equal shares of Americans prefer news outlets and social media when it comes to opinions on an issue (22% each).

Previous Center research has shown that younger Americans are more likely than older Americans to prefer getting news from social media , and that pattern also appears in the findings of this survey. Adults under 30 express a clear preference for using social media over news outlets to get opinions on an issue (36% vs. 13%) and up-to-date information as an event is happening (35% vs. 21%). Americans ages 65 and older are much more likely to prefer news outlets over social media for every type of information we asked about. 

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Luxuan Wang is a research associate at Pew Research Center

Naomi Forman-Katz is a research analyst focusing on news and information research at Pew Research Center

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Restoring sight is possible now with optogenetics

People suffering from macular degeneration, along with other diseases that impair sight, may soon benefit from gene therapy

As a child, Max Hodak learned to develop film in a darkroom with his late grandfather who was almost blind.

Hodak’s grandfather had retinitis pigmentosa, a congenital disease that affects one out of every 5,000 people — more than 2 million worldwide. Most people with the condition are born with their sight intact. Over time they lose peripheral vision first, then central vision, and finally, their sight, sometimes as early as middle age.

“He clearly had this career and was a photographer, and I saw that,” Hodak said of his grandfather, who became an aerospace engineer and briefly worked on heat shields for spacecraft. “But most of my memories as a kid was that he was pretty profoundly blind.”

Possible solutions, though, are within reach. Science, a start-up company in Alameda, Calif., has designed a visual prosthesis called the Science Eye which could restore vision, albeit in a limited form, in people with retinitis pigmentosa. Hodak, its CEO, co-founded the startup after a stint at Elon Musk’s company Neuralink. Other companies such as Paris-based biotechnology company GenSight Biologics and Bionic Sight in New York are also experimenting with methods to restore sight.

All are basing their work on a research tool in neuroscience called optogenetics, a form of gene therapy that delivers proteins called opsins via injection into the eye to boost the light sensitivity of cells in the retina, the layer of tissue at the rear of the eyeball.

Therapeutic optogenetic therapy for vision restoration certainly has promise, according to Anand Swaroop, a senior investigator at the National Eye Institute in Bethesda, Md., who has worked on inherited retinal degeneration for close to four decades. But there’s still room for improvement.

“At least at this stage, it seems to be very good in cases where someone is completely blind,” Swaroop said. “You should be able to find your way around. You’re not going to bump into things, which is great. But you’re not going to be distinguishing many different features.”

How optogenetics work

In normal vision, light enters the eye through the lens and forms an image on the retina. The retina itself is composed of several different types of cells, mainly photoreceptors. Photoreceptors are light-sensing cells shaped like rods and cones that contain opsins. Normally, photoreceptors convert light into electrical signals that travel to the retina’s ganglion cells, which in turn transmit those electrical signals via the optic nerve into the brain. That’s how you’re reading the words on this page right now.

In retinitis pigmentosa, the rods and cones in the photoreceptors break down and ultimately die. First the peripheral vision goes, and people develop tunnel vision: They have to turn their whole head just to view the world around them. Many people with tunnel vision require a cane to assist in navigating the world (and to avoid bumping into things, like furniture.) Blindness follows not long after. The breakdown of the photoreceptors, however, doesn’t diminish the brain’s ability to process electrical signals — and, critically, the ganglion cells remain intact.

Optogenetics seeks to circumvent the usual choreography by delivering opsin proteins directly to the ganglion cells, meaning they can be stimulated by light in order to send signals to the brain.

The Science Eye contains two elements. The first is an implant composed of a wireless power coil and an ultrathin, flexible micro-LED array that’s applied directly over the retina — surgery that’s more extensive compared to other eye procedures like repairing cataracts. According to Hodak, the array — prototypes of which are being tested in rabbits — provides eight times the resolution of an iPhone screen.

The second element is a pair of frameless glasses, similar in size and shape to regular prescription glasses, that contain miniature infrared cameras and inductive power coils.

Put it all together and the process looks like this:

Inject opsins into the ganglion cells of the eye.

Install the implant.

The glasses activate the modified ganglion cells by wirelessly communicating information from the visual world; in turn, the new light-sensitive ganglion cells transmit that information through the optic nerve to the brain.

The eye isn’t receiving an image anymore, but rather digital information. And the results?

“You should be able to walk across town to buy a sandwich without being hit by a car,” Hodak said.

More research into retinitis pigmentosa

Other companies are already helping to bring back vision in people with retinitis pigmentosa.

GenSight Biologics uses an optogenetics-plus-glasses approach to amplify light that genetically edited ganglion cells can decode. According to clinical trial results published in 2021 in the journal Nature Medicine, GenSight’s method was able to help in locating objects on a table. That patient, a 58-year-old man, was diagnosed with retinitis pigmentosa at age 18.

Innovations

Bionic Sight has firsthand experience with patients beginning to make distinctions between features. Its method involves a gene-therapy vector that transfers an opsin called Chronos via injection into the eyes of their patients to boost the light sensitivity of intact ganglion cells. For those with tunnel vision, the injection of the opsin seems to be enough.

For patients with more impaired vision, Bionic Sight pairs the optogenetic therapy with a pair of goggles containing a camera and a neurocoding device: The camera takes in images and converts them to code, which is then sent out as light pulses to activate the opsin in the genetically modified ganglion cells. So far Bionic Sight has treated 13 people, ranging from the very blind to patients with tunnel vision.

“It’s really significantly helping,” said Sheila Nirenberg, founder of Bionic Sight as well as a professor of computational neuroscience at Weill Cornell Medical College.

Consider the large letter “E” on the eye chart you might examine during a visit to the doctor’s office. The visual acuity of a person who is nearly blind is 20/200: What someone with 20/20 vision is able to see at 200 feet away is only visible at 20 feet away to someone who is nearly blind.

Many of her patients with retinitis pigmentosa, Nirenberg said, can’t see a letter like the big “E” from just two feet away. But one patient whose visual acuity was 20/150 — he had to stand 20 feet away from the chart in order to see the letters, whereas a normally-sighted person could stand 150 feet away and see the same letters — is now down to 20/40. Another patient was unable to distinguish the suits on playing cards. After receiving the opsin, the patient was not only able to tell the difference between clubs and diamonds, for instance, but he was also able to notice the differences in color.

Another challenge had him trying to spot differences between plastic fruits arranged in front of him. He was able to spot the stem of the apple to tell it apart from oranges and peaches. Finally, he was asked to walk a maze with black squares on the bottom — and made it through successfully.

“I can’t explain to you how thrilling it is,” Nirenberg said. “It’s very hopeful.”

One form of gene therapy for treating blindness has been available for over five years. Luxturna, a prescription approved by the Food and Drug Administration in 2017, is for children and adults with a rare genetic mutation that impacts the retinal pigment epithelium, the membrane at the back of the retina on which the photoreceptors sit. The prescription adds in a functional version of the gene to create an epithelium more favorable to the photoreceptors.

“It might slow the progression of the disease,” Hodak said. “But it does not regenerate any loss.”

That, ultimately, is the goal of Science Eye. Clinical trials should begin, Hodak said, sometime in the next 18 months. The company is also looking at ways to use Science Eye to help people with dry age-related macular degeneration, which unfolds slightly differently compared with retinitis pigmentosa: Patients lose central, high-resolution vision first, and then their peripheral vision.

There are milestones to cross for every company using optogenetics to help people improve their eyesight. More patients enrolled in clinical trials should help refine both opsin delivery and the ability to improve light sensitivity in retinal cells. But Hodak predicts that over the next five years, there will be products on the market for people like his grandfather.

“You always have to be really careful with what you say to patients because they’re holding on for any piece of hope,” Hodak said. “But there’s a lot of things on the horizon that are converging. It’s not at a point where any one thing will fail and derail the whole field. Real progress is coming.”

About this story

Bionic Eye illustrations by Washington Post; Science. Editing by Bronwen Latimer. Copy editing by Paola Ruano. Design and development by Audrey Valbuena. Design editing by Betty Chavarria. Photo editing by Haley Hamblin. Project development by Evan Bretos and Hope Corrigan. Project editing by Marian Chia-Ming Liu.

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How to Thrive as You Age

Got tinnitus a device that tickles the tongue helps this musician find relief.

Allison Aubrey

After using the Lenire device for an hour each day for 12 weeks, Victoria Banks says her tinnitus is "barely noticeable." David Petrelli/Victoria Banks hide caption

After using the Lenire device for an hour each day for 12 weeks, Victoria Banks says her tinnitus is "barely noticeable."

Imagine if every moment is filled with a high-pitched buzz or ring that you can't turn off.

More than 25 million adults in the U.S., have a condition called tinnitus, according to the American Tinnitus Association. It can be stressful, even panic-inducing and difficult to manage. Dozens of factors can contribute to the onset of tinnitus, including hearing loss, exposure to loud noise or a viral illness.

There's no cure, but there are a range of strategies to reduce the symptoms and make it less bothersome, including hearing aids, mindfulness therapy , and one newer option – a device approved by the FDA to treat tinnitus using electrical stimulation of the tongue.

The device has helped Victoria Banks, a singer and songwriter in Nashville, Tenn., who developed tinnitus about three years ago.

"The noise in my head felt like a bunch of cicadas," Banks says. "It was terrifying." The buzz made it difficult for her to sing and listen to music. "It can be absolutely debilitating," she says.

Shots - Health News

Tinnitus bothers millions of americans. here's how to turn down the noise.

Banks tried taking dietary supplements , but those didn't help. She also stepped up exercise, but that didn't bring relief either. Then she read about a device called Lenire, which was approved by the FDA in March 2023. It includes a plastic mouthpiece with stainless steel electrodes that electrically stimulate the tongue. It is the first device of its kind to be approved for tinnitus.

"This had worked for other people, and I thought I'm willing to try anything at this point," Banks recalls.

She sought out audiologist Brian Fligor, who treats severe cases of tinnitus in the Boston area. Fligor was impressed by the results of a clinical trial that found 84% of participants who tried Lenire experienced a significant reduction in symptoms. He became one of the first providers in the U.S. to use the device with his patients. Fligor also served on an advisory panel assembled by the company who developed it.

"A good candidate for this device is somebody who's had tinnitus for at least three months," Fligor says, emphasizing that people should be evaluated first to make sure there's not an underlying medical issue.

Tinnitus often accompanies hearing loss, but Victoria Banks' hearing was fine and she had no other medical issue, so she was a good candidate.

Banks used the device for an hour each day for 12 weeks. During the hour-long sessions, the electrical stimulation "tickles" the tongue, she says. In addition, the device includes a set of headphones that play a series of tones and ocean-wave sounds.

The device works, in part, by shifting the brain's attention away from the buzz. We're wired to focus on important information coming into our brains, Fligor says. Think of it as a spotlight at a show pointed at the most important thing on the stage. "When you have tinnitus and you're frustrated or angry or scared by it, that spotlight gets really strong and focused on the tinnitus," Fligor says.

"It's the combination of what you're feeling through the nerves in your tongue and what you're hearing through your ears happening in synchrony that causes the spotlight in your brain to not be so stuck on the tinnitus," Fligor explains.

A clinical trial found 84% of people who used the device experienced a significant reduction in symptoms. Brian Fligor hide caption

A clinical trial found 84% of people who used the device experienced a significant reduction in symptoms.

"It unsticks your spotlight" and helps desensitize people to the perceived noise that their tinnitus creates, he says.

Banks says the ringing in her ears did not completely disappear, but now it's barely noticeable on most days.

"It's kind of like if I lived near a waterfall and the waterfall was constantly going," she says. Over time, the waterfall sound fades out of consciousness.

"My brain is now focusing on other things," and the buzz is no longer so distracting. She's back to listening to music, writing music, and performing music." I'm doing all of those things," she says.

When the buzz comes back into focus, Banks says a refresher session with the device helps.

A clinical trial found that 84% of people who tried Lenire , saw significant improvements in their condition. To measure changes, the participants took a questionnaire that asked them to rate how much tinnitus was impacting their sleep, sense of control, feelings of well-being and quality of life. After 12 weeks of using the device, participants improved by an average of 14 points.

"Where this device fits into the big picture, is that it's not a cure-all, but it's quickly become my go-to," for people who do not respond to other ways of managing tinnitus, Fligor says.

One down-side is the cost. Banks paid about $4,000 for the Lenire device, and insurance doesn't cover it. She put the expense on her credit card and paid it off gradually.

Fligor hopes that as the evidence of its effectiveness accumulates, insurers will begin to cover it. Despite the cost, more than 80% of participants in the clinical trial said they would recommend the device to a friend with tinnitus.

But, it's unclear how long the benefits last. Clinical trials have only evaluated Lenire over a 1-year period. "How durable are the effects? We don't really know yet," says audiologist Marc Fagelson, the scientific advisory committee chair of the American Tinnitus Association. He says research is promising but there's still more to learn.

Fagelson says the first step he takes with his patients is an evaluation for hearing loss. Research shows that hearing aids can be an effective treatment for tinnitus among people who have both tinnitus and hearing loss, which is much more common among older adults. An estimated one-third of adults 65 years of age and older who have hearing loss, also have tinnitus.

"We do see a lot of patients, even with very mild loss, who benefit from hearing aids," Fagelson says, but in his experience it's about 50-50 in terms of improving tinnitus. Often, he says people with tinnitus need to explore options beyond hearing aids.

Bruce Freeman , a scientist at the University of Pittsburgh Medical Center, says he's benefitted from both hearing aids and Lenire. He was fitted for the device in Ireland where it was developed, before it was available in the U.S.

Freeman agrees that the ringing never truly disappears, but the device has helped him manage the condition. He describes the sounds that play through the device headphones as very calming and "almost hypnotic" and combined with the tongue vibration, it's helped desensitize him to the ring.

Freeman – who is a research scientist – says he's impressed with the results of research, including a study published in Nature, Scientific Reports that points to significant improvements among clinical trial participants with tinnitus.

Freeman experienced a return of his symptoms when he stopped using the device. "Without it the tinnitus got worse," he says. Then, when he resumed use, it improved.

Freeman believes his long-term exposure to noisy instruments in his research laboratory may have played a role in his condition, and also a neck injury from a bicycle accident that fractured his vertebra. "All of those things converged," he says.

Freeman has developed several habits that help keep the high-pitched ring out of his consciousness and maintain good health. "One thing that does wonders is swimming," he says, pointing to the swooshing sound of water in his ears. "That's a form of mindfulness," he explains.

When it comes to the ring of tinnitus, "it comes and goes," Freeman says. For now, it has subsided into the background, he told me with a sense of relief. "The last two years have been great," he says – a combination of the device, hearing aids and the mindfulness that comes from a swim.

This story was edited by Jane Greenhalgh

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Federal grant to advance brain stroke research

UCR engineering professor awarded $3 million to develop predictive models from brain scans

While stroke remains a leading cause of death and disability in the United States, one area of hope lies in learning more about the network of “backup” blood vessels in the brain.

Kaveh Laksari , a UC Riverside assistant professor of mechanical engineering, hopes to close the knowledge gap with research funded by a $3 million grant awarded this month by the National Institutes of Health.

Laksari’s research will focus on the role of backup vessels, called collaterals, in restoring blood flow to affected areas of the brain following acute ischemic strokes (AIS), which are caused by blockages in larger vessels. Therapies to redirect blood flow in the brain following a stroke are effective only if they occur quickly and precisely. Physicians, however, are now hampered by the complexity of collateral vessels because they are so small and intricate.

“We will study anatomic and morphologic features in the brain’s vasculature during ischemic stroke to better assess stroke severity and improve outcome predictions,” Laksari said. “I am grateful for this opportunity and look forward to getting started.”

While timely diagnosis of AIS and accurate predictions of response to blood flow restoration therapies are key to guiding treatment strategies, accurate and reliable predictive models are lacking despite efforts to use many clinical and imaging biomarkers.

Laksari and his collaborators will use the grant to create new predictive models. They have already developed an algorithm that gathers data about the morphologic and geometric features of the brain’s vascular system from commonly used MRI and CT angiography scans of the brains of healthy people and stroke patients.

The five-year grant will allow Laksari to further develop the algorithm to automatically extract complex cerebrovascular morphology data in real-time. He will work to develop models to analyze the collateral vessel structures and other information collected following patient hospital admissions to predict major complications and long-term outcomes after a stroke.

Laksari’s collaborators include Dr. Pouya Tahsili-Fahadan, the stroke medical director at Inova Fairfax Hospital in Virginia and an assistant professor of medical education at the University of Virginia; Dr. Max Wintermark, professor and chair of neuroradiology at the University of Texas MD Anderson Cancer Center; Dr. Ramin Zand, professor of neurology at Penn State University; and Dr. Vida Abedi, associate professor at Penn State’s Department of Public Health Sciences.

Cover illustration by Getty Images

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